Sex differences in inflammatory control mediated by nuclear receptors

• Project/Area Number: 20590304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA Sumito The University of Tokyo, 医学部附属病院, 講師 (20323579)
• Co-Investigator(Renkei-kenkyūsha): AKISHITA Masahiro 東京大学, 医学部附属病院, 准教授 (00261975)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 老年病 / 性差医学 / 炎症 / 性ホルモン

Research Abstract

In this study, anti-inflammatory control by sex hormones and its nuclear receptors were investigated based on quantitative PCR and microarray studies and transcription analysis in primary macrophages. It was suggested that each sex hormone exert overlapping and distinct sets of anti-inflammatory control, suggesting sex differences in nuclear receptor-mediated transrepression.

Research Products

• [Journal Article] Plasma sex hormone levels and mortality in disabled older men and women. (2010)
  • Author(s): Fukai S, Akishita M, Yamada S, Ogawa S, Yamaguchi K, Kozaki K, Toba K, Ouchi Y
  • Journal Title: Geriatr Gerontol Int.
  • NAID: 10029333495
  • Peer Reviewed
• [Journal Article] Visceral fat accumulation and metabolic risk factor clustering in older adults. (2010)
  • Author(s): Nomura K, Eto M, Kojima T, Ogawa S, Iijima K, Nakamura T, Araki A, Akishita M, Ouchi Y
  • Journal Title: J Am Geriatr Soc. 58 Pages: 1658-1663
  • Peer Reviewed
• [Journal Article] Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway. (2010)
  • Author(s): Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: Arterioscler Thromb Vasc Biol. 30 Pages: 2205-2211
  • Peer Reviewed
• [Journal Article] Effects of testosterone in older men with mild-to-moderate cognitive impairment. (2010)
  • Author(s): Fukai S, Akishita M, Yamada S, Toba K, Ouchi Y
  • Journal Title: J Am Geriatr Soc. 58 Pages: 1419-1421
  • Peer Reviewed
• [Journal Article] Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment. (2010)
  • Author(s): Yamada S, Akishita M, Fukai S, Ogawa S, Yamaguchi K, Matsuyama J, Kozaki K, Toba K, Ouchi Y
  • Journal Title: Geriatr Gerontol Int. 10 Pages: 280-287
  • NAID: 10027755257
  • Peer Reviewed
• [Journal Article] Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men. (2010)
  • Author(s): Akishita M, Fukai S, Hashimoto M, Kameyama Y, Nomura K, Nakamura T, Ogawa S, Iijima K, Eto M, Ouchi Y
  • Journal Title: Hypertens Res. 33 Pages: 587-591
  • NAID: 10026397148
  • Peer Reviewed
• [Journal Article] SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. (2010)
  • Author(s): Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: J Atheroscler Thromb. 17 Pages: 431-435
  • NAID: 130004845303
  • Peer Reviewed
• [Journal Article] Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells : role of phosphatidylinositol 3-kinase/akt pathway. (2010)
  • Author(s): Yu J, Akishita M, Eto M, Ogawa S, Son BK, Kato S, Ouchi Y, Okabe T
  • Journal Title: Endocrinology. 151 Pages: 1822-1828
  • Peer Reviewed
• [Journal Article] Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers. (2010)
  • Author(s): Fukai S, Akishita M, Miyao M, Ishida K, Toba K, Ouchi Y
  • Journal Title: Geriatr Gerontol Int. 10 Pages: 32-39
  • NAID: 10027271554
  • Peer Reviewed
• [Journal Article] Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. (2010)
  • Author(s): Son BK, Akishita M, Iijima K, Ogawa S, Maemura K, Yu J, Takeyama K, Kato S, Eto M, Ouchi Y
  • Journal Title: J Biol Chem. 285 Pages: 7537-7544
  • Peer Reviewed
• [Journal Article] Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors. (2010)
  • Author(s): Iijima K, Hashimoto H, Hashimoto M, Son BK, Ota H, Ogawa S, Eto M, Akishita M, Ouchi Y
  • Journal Title: Atherosclerosis. 210 Pages: 137-144
  • Peer Reviewed
• [Journal Article] Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors. (2010)
  • Author(s): Akishita M, Hashimoto M, Ohike Y, Ogawa S, Iijima K, Eto M, Ouchi Y
  • Journal Title: Atherosclerosis. 210 Pages: 232-236
  • Peer Reviewed
• [Presentation] 地域在住高齢者の転倒リスク、活力度と食生活習慣との関連性 (2010)
  • Author(s): 小川純人、柴崎孝二、山口潔、山田思鶴、浜達哉、神崎恒一、鳥羽研二、秋下雅弘、大内尉義
  • Organizer: 日本成人病(生活習慣病)学会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-09
• [Presentation] 地域在住高齢者における食品摂取状況の性差およびるい痩との関連性 (2010)
  • Author(s): 柴崎孝二、小川純人、山口潔、山田思鶴、浜達哉、神崎恒一、鳥羽研二、秋下雅弘、大内尉義
  • Organizer: 日本成人病(生活習慣病)学会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-09
• [Presentation] Fracture prevention and hormone. (2009)
  • Author(s): 小川純人
  • Organizer: 5^<th> Congress of Asia Pacific Society for the Study of Aging Male.
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-16
• [Book] 総合臨床(骨粗鬆症の治療法 エストロゲンとSERM 59) (2010)
  • Author(s): 小川純人
• [Book] Clinical Neuroscience.(性差から見た老年病 27) (2009)
  • Author(s): 小川純人、大内尉義
• [Book] 細胞工学(核内受容体を介した抗炎症作用 28) (2009)
  • Author(s): 小川純人
• [Book] Geriatric Medicine.(性ステロイドと転倒 47) (2009)
  • Author(s): 小川純人、秋下雅弘
• [Remarks] ホームページ等