Real time imaging & morphological analysis of cell death induced by chemotherapy & radiotherapy in vivo
| Project/Area Number |
20590307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SHIRAI Toshiharu Kanazawa University, 医学系, 助教 (20397186)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がん細胞 / 形態学的細 / リアルタイム / GFP / RFP / in vivo / 紫外線 / 形態学的細胞死 / アポトーシス |
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| Research Abstract |
We observed morphology of in vivo cell death, induced by anti-cancer agent or ultraviolet light, using dual-color cancer cells in which GFP was expressing in nucleus and RFP in cytoplasm. As results, we found several morphologies of cell death, even though there is usually said to be only two categories for cell death, apoptosis and necrosis. We also found that those morphologic differences were dependent on cell line, anti-cancer drug, and wave length of radiation.
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Report
(4 results)
Research Products
(39 results)
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[Presentation] 大腿骨遠位骨肉腫症例の再建法2009
Author(s)
白井寿治, 土屋弘行, 林克洋, 大成一誓, 三輪真嗣, 富田勝郎
Organizer
骨軟部腫瘍外科研究会
Place of Presentation
がん研有明病院(東京)
Year and Date
2009-03-28
Related Report
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