Reduceds β-cell proliferation and impaired glucose tolerance in pancreatics β-cell specific Extl3 knockout mice.

• Project/Area Number: 20590312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Iwate Medical University
• Principal Investigator: NATA Koji Iwate Medical University, 薬学部, 教授 (90202233)
• Co-Investigator(Kenkyū-buntansha): SUGAWARA Akira 東北大学, 大学院・医学系研究科, 教授 (90270834)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵β細胞 / 糖尿病 / 糖鎖 / ヘパラン硫酸 / 糖転移酵素 / EXTL3 / ノックアウトマウス / 膵ランゲルハンス島 / EXTファミリー / 遺伝性多発外骨腫 / 遺伝性多発性外骨腫

Research Abstract

EXTL3 functions as a glycosyltransferase involved in heparan sulfate proteoglycans biosynthesis. We generated pancreatic β-cell specific Extl3 knockout (βExtl3KO) mice. In βExtl3KO mice at 2-8 weeks old, the β-cell proliferation activity was decreased and histological examination of pancreatic islets revealed an atypical organization. βExtl3KO mice at 8 weeks old showed glucose intolerance coupled to impaired insulin secretion upon glucose challenge. These data indicate that heparan sulfate plays important role(s) in β-cell proliferation and the mechanism of insulin secretion.

Research Products

• [Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-δ. (2011)
  • Author(s): Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
  • Journal Title: J Leukoc Biol. in press
  • Peer Reviewed
• [Journal Article] Expression profile of the REG gene family in colorectal carcinoma. (2011)
  • Author(s): Zheng HC, Sugawara A, Okamoto H, Takasawa S, Takahashi H, Masuda S, Takano Y.
  • Journal Title: J Histochem Cytochem. vol.59 Pages: 106-115
  • Peer Reviewed
• [Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene(Am80)differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-{delta}. (2011)
  • Author(s): Uruno, A.
  • Journal Title: J.Leukoc.Biol. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor-γ suppresses CYP11B2 expression and aldosterone production. (2011)
  • Author(s): Uruno, A.
  • Journal Title: J.Mol.Endocrinol. Volume: 46 Pages: 37-39
  • Peer Reviewed
• [Journal Article] Expression profile of the REG gene family in colorectal carcinoma. (2011)
  • Author(s): Zheng, H.C.
  • Journal Title: J.Histochem.Cytochem. Volume: 59 Pages: 106-115
  • Peer Reviewed
• [Journal Article] A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene. (2010)
  • Author(s): Takasawa S, Kuroki M, Nata K, Noguchi N, Ikeda T, Yamauchi A, Ota H, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takahashi I, Yoshikawa T, Shimosegawa T, Okamoto H.
  • Journal Title: Biochem Biophys Res Commun. Vol.397 Pages: 140-145
  • Peer Reviewed
• [Journal Article] Up-regulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes. (2010)
  • Author(s): Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y.
  • Journal Title: Int J Cancer. vol.127 Pages: 1795-1803
  • Peer Reviewed
• [Journal Article] A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene. (2010)
  • Author(s): Takasawa, S.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 397 Pages: 140-145
  • Peer Reviewed
• [Journal Article] Up-regulation of REG 1α accelerates tumor progression in pancreatic cancer with diabetes. (2010)
  • Author(s): Zhou, L.
  • Journal Title: Int.J.Cancer Volume: 127 Pages: 1795-1803
  • Peer Reviewed
• [Journal Article] Important role of heparan sulfate in the morphogenesis, s-cell proliferation, and insulin secretion of mouse pancreatic islets. (2009)
  • Author(s): Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A.
  • Journal Title: Biochem Biophys Res Commun. vol.383 Pages: 113-118
  • Peer Reviewed
• [Journal Article] Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells. (2009)
  • Author(s): Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A.
  • Journal Title: Biochem Biophys Res Commun. vol.379 Pages: 743-748
  • Peer Reviewed
• [Journal Article] Assisting the diagnosis of Graves' hyperthyroidism with Bayesian-type and SOM-type neural networks by making use of a set of three routine tests and their correlation with free T4. (2009)
  • Author(s): Sato, W.
  • Journal Title: Biomed. Pharmacother. 59 Pages: 288-293
  • Peer Reviewed
• [Journal Article] Thiazolidinediones inhibit REG Ia gene transcription in gastrointestinal cancer cells. (2009)
  • Author(s): Yamauchi, A.
  • Journal Title: Biochem. Biophys. Res.Commun. 379 Pages: 743-748
  • Peer Reviewed
• [Journal Article] Important role of heparan sulfate in the morphogenesis, ss-cell proliferation, and insulin secretion of mouse pancreatic islets. (2009)
  • Author(s): Takahashi, I.
  • Journal Title: Biochem. Biophys. Res.Commun. 383 Pages: 113-118
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor gamma (PPAR_Y) in human prostate carcinoma. (2009)
  • Author(s): Nakamura, Y.
  • Journal Title: Pathol.Int. 59 Pages: 288-293
  • Peer Reviewed
• [Journal Article] Thiazolidinediones inhibit REG la gene transcription in gastrointestinal cancer cells. (2009)
  • Author(s): Yamauchi, A.
  • Journal Title: Biochemical Biophy-sical Research Communications 379 Pages: 743-748
  • Peer Reviewed
• [Journal Article] FKBP12.6 disruption impairs glucose-induced insulin secretion. (2008)
  • Author(s): Noguchi N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A.
  • Journal Title: Biochem Biophys Res Commun. vol.371 Pages: 735-740
  • Peer Reviewed
• [Journal Article] FKBP12.6 disruption impairs glucose-induced insulin secretion. (2008)
  • Author(s): Noguchi, N.
  • Journal Title: Biochemical Biophysical Research Communications 371 Pages: 735-740
  • Peer Reviewed
• [Journal Article] Stimulatory effects of low-dose 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis : involvement of p38 mitogen-activated protein kinase. (2008)
  • Author(s): Uruno, A.
  • Journal Title: Hypertension Research 31 Pages: 2085-2096
  • Peer Reviewed
• [Journal Article] Impaired glucose-induced insulin secretion in FK506-binding protein 12.6-deficient mice. (2008)
  • Author(s): Yoshikawa, T.
  • Journal Title: Diabetes 57
  • Peer Reviewed
• [Journal Article] Reduced B-cell proliferation and impaired glucose tolerance in pancreatic B-cell specific Extl3 knockout mice. (2008)
  • Author(s): Takahashi I.
  • Journal Title: Diabetologia 51
  • Peer Reviewed
• [Presentation] Contribution of heparan sulfate fine structure to Insulin secretion. (2010)
  • Author(s): Takahashi I, Ohashi K, Shervani NJ, Nata K.
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Contribution of heparin sulfate fine structure to Insulin secretion. (2010)
  • Author(s): Takahashi, I.
  • Organizer: 第83回 日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Structural characterization of heparan sulfate in the Extl3 knockout mice and the pancreatic β-cell specific Extl3 knockout mice. (2010)
  • Author(s): Kaneiwa T, Yamada S, Sugahara K, Takahashi I, Noguchi N, Nata K, Okamoto H, Sugawara A
  • Organizer: 25th International Carbohydrate Symposium.
  • Place of Presentation: Tokyo
  • Year and Date: 2010-08-02
• [Presentation] Structural characterization of heparin sulfate in the Extl3 knockout mice and the pancreatic β-cell specific Extl3 knockout mice. (2010)
  • Author(s): Kaneiwa, T.
  • Organizer: 25th International Carbohydrate Symposium
  • Place of Presentation: 東京
  • Year and Date: 2010-08-02
• [Presentation] Role of heparan sulfate in glucose-induced insulin secretion in mouse pancreatic β-cell line MIN6 cells. (2010)
  • Author(s): Yoshikawa T, Takayanagi S, Noguchi N, Zhang D, Ariyama Y, Uruno A, Okamoto H, Sugawara A, Yanai K.
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology.
  • Place of Presentation: Copenhagen
  • Year and Date: 2010-07-20
• [Presentation] Role of heparan sulfate in glucose-induced insulin secretion in mouse pancreatic β-cell line MIN6 cells. (2010)
  • Author(s): Yoshikawa, T.
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology
  • Place of Presentation: Copenhagen
  • Year and Date: 2010-07-20
• [Presentation] Role of heparan sulfate in glucose-induced insulin secretion in MIN6 cells. (2010)
  • Author(s): Yoshikawa, T.
  • Organizer: American Diabetes Association 70th Scientific Sessions
  • Place of Presentation: Orlando
  • Year and Date: 2010-06-26
• [Presentation] Role of heparan sulfate in glucose-induced insulin secretion in MIN6 cells. (2010)
  • Author(s): Yoshikawa T, Takayanagi S, Noguchi N, Uruno A, Okamoto H, Sugawara A, Yanai K.
  • Organizer: American Diabetes Association 70th Scientific Sessions.
  • Place of Presentation: Orlando
  • Year and Date: 2010-06-02
• [Presentation] (2010)
  • Author(s): Shervani NJ, Takahashi I, Ohashi K, Noguchi N, Okamoto H, Takasawa S, Sugawara A, Nata K.
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] A study on the effect of autoantibodies to human REG(Regenerating gene)family proteins in type 1 and type 2 diabetes. (2010)
  • Author(s): Shervani, N.J.
  • Organizer: 第53回 日本糖尿病学会次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] The role of regenerating gene 1 in Entamoeba histolytica colitis. (2010)
  • Author(s): Peterson, K.
  • Organizer: 48th Annual Meeting of Infectious Diseases Society of America
  • Place of Presentation: Vancouver
• [Presentation] Measurements of aldosterone in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) : comparison to radioimmunoassays. (2010)
  • Author(s): Kudo, M.
  • Organizer: International Symposium for Aldosterone and Related Substances in Hypertension.
  • Place of Presentation: 仙台
• [Presentation] Prostacyclin analogs rapidly stimulates endothelial nitricoxide synthase phosphorylation through cAMP/PKA pathway in vascular endothelial cells. (2010)
  • Author(s): Kudo, M.
  • Organizer: 14th International Congress of Endocrinology.
  • Place of Presentation: 京都
• [Presentation] Measurements of aldosterone in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) : comparison to radioimmunoassays. (2010)
  • Author(s): Kudo, M.
  • Organizer: 14th International Congress of Endocrinology.
  • Place of Presentation: 京都
• [Presentation] Negative regulation of CYP11B2 expression and aldosterone production in adrenocortical carcinoma H295R cells by PPAR_Y. (2010)
  • Author(s): Uruno, A.
  • Organizer: 14th International Congress of Endocrinology.
  • Place of Presentation: 京都
• [Presentation] Role of retinoic acid receptor on ACTH secretion and POMC gene expression in AtT.20 corticotroph cells. (2010)
  • Author(s): Uruno, A.
  • Organizer: 14th International Congress of Endocrinology.
  • Place of Presentation: 京都
• [Presentation] Sera from Japanese diabetes patients show autoimmunity to REG family antigens. (2009)
  • Author(s): Shervani NJ, Nata K, Noguchi N, Takahashi I, Ikeda T, Ohashi K, Yoshikawa T, Uruno A, Takasawa S, Okamoto H, Sugawara A
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 2型リアノジン受容体遺伝子にはGG-AG配列で切断されるイントロンが存在する (2009)
  • Author(s): 池田崇之, 野口直哉, 吉川雄朗, 宇留野晃, 那谷耕司, 高澤伸, 岡本宏, 米倉秀人, 菅原明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Sera from Japanese diabetes patients show autoimmunity to REG family antigens. (2009)
  • Author(s): Shervani, N.J.
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 2型リアノジン受容体遺伝子にはGG-AG配列で切断されるイントロンが存在する (2009)
  • Author(s): 池田崇之
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Prostacyclin analogs rapidly induce nitric oxide production through endothelial nitric oxide synthase phosphorylation in vascular endothelial cells. (2009)
  • Author(s): Kudo, M.
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation.
  • Place of Presentation: 松島
  • Year and Date: 2009-06-02
• [Presentation] Structural characterization of heparan sulfate in conventional and conditional Extl3-deficient mice. (2009)
  • Author(s): Kaneiwa T, Yamada S, Sugahara K, Takahashi I, Noguchi N, Nata K, Okamoto H, Sugawara A
  • Organizer: Hokkaido University-Mahidol University Joint Symposium.
  • Place of Presentation: Sapporo
  • Year and Date: 2009-05-12
• [Presentation] Structural characterization of heparan sulfate in conventional and conditional Extl3-deficient mice. (2009)
  • Author(s): Kaneiwa, T.
  • Organizer: Hokkaido University-Mahidol University Joint Symposium.
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-12
• [Presentation] Predominant role of REG Iα among the REG gene family in the proliferation of human colorectal adenocarcinoma. (2009)
  • Author(s): Yoshikawa T, Ikeda T, Sakai K, Noguchi N, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Sakai E, Onogawa T, Okabe M, Ando T, Kinouchi M, Miura K, Unno M, Emura T, Fujiwara M, Takasawa S, Okamoto H, Sugawara A
  • Organizer: American Association for Cancer Research 100th Annual Meeting 2009.
  • Place of Presentation: Denver
  • Year and Date: 2009-04-22
• [Presentation] Predominant role of REG Ia among the REG gene family in the proliferation of human colorectal adenocarcinoma. (2009)
  • Author(s): Yoshikawa, T.
  • Organizer: American Association for Cancer Research 100th Annual Meeting 2009.
  • Place of Presentation: Denver
  • Year and Date: 2009-04-04
• [Presentation] Extl3ノックアウトマウスにおけるヘパラン硫酸の分析 (2009)
  • Author(s): 金岩知之, 山田修平, 菅原一幸, 高橋巌, 野口直哉, 那谷耕司, 岡本宏, 菅原明
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] Ext13ノックアウトマウスにおけるヘパラン硫酸の分析 (2009)
  • Author(s): 金岩知之
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-03-26
• [Presentation] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-δ. (2009)
  • Author(s): Uruno A, Noguchi N, Nata K, Yoshikawa T, Takahashi I, Shervani NJ, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A
  • Organizer: The Endocrine Society 91st Annual Meeting.
  • Place of Presentation: Washington, DC
• [Presentation] Autoantibodies to REG family proteins in Japanese diabetes patients. (2009)
  • Author(s): Shervani NJ, Noguchi N, Ikeda T, Takahashi I, Yoshikawa T, Uruno A, Nata K, Takasawa S, Okamoto H, Sugawara A
  • Organizer: 45th Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Vienna
• [Presentation] Autoimmunity against REG family antigens in Japanese diabetes patients. (2009)
  • Author(s): Shervani NJ, Nata K, Noguchi N, Takahashi I, Ikeda T, Yamauchi A, Yoshikawa T, Uruno A, Takasawa S, Okamoto H, Sugawara A
  • Organizer: The 20th World Diabetes Congress.
  • Place of Presentation: Montreal
• [Presentation] PPARgamma suppresses angiotensin II- and potassium-induced CYP11B2 expression and aldosterone production in adrenocortical carcinoma H295 cells. (2009)
  • Author(s): Uruno, A.
  • Organizer: The 35th International Aldosterone Conference.
  • Place of Presentation: Washington, DC
• [Presentation] Retinoic acid receptor-alpha positively regulates ACTH secretion and POMC gene expression in AtT20 corticotroph cells. (2009)
  • Author(s): Uruno, A.
  • Organizer: The Endocrine Society 91st Annual Meeting.
  • Place of Presentation: Washington, DC
• [Presentation] マウス膵ランゲルハンス島の形態形成やβ細胞増殖,インスリン分泌機能におけるヘパラン硫酸の重要性 (2008)
  • Author(s): 高橋巌, 野口直哉, 那谷耕司, 山田修平, 金岩知之, 水本秀二, 池田崇之, 杉原一司, 浅野雅秀, 吉川雄朗, Nausheen J. Shervani, 宇留野晃, 海野倫明, 菅原一幸, 高澤伸, 岡本宏, 菅原明
  • Organizer: 第20回分子糖尿病学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-13
• [Presentation] マウス膵ランゲルハンス島の形態形成やβ細胞増殖、インスリン分泌機能におけるヘパラン硫酸の重要性。 (2008)
  • Author(s): 高橋 巌
  • Organizer: 第20回分子糖尿病学シンポジウム
  • Place of Presentation: 東京コンファレンスセンター品川
  • Year and Date: 2008-12-13
• [Presentation] 消化器癌における全REG遺伝子の発現解析および増殖効果の検討。 (2008)
  • Author(s): 吉川雄朗
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] ヘパラン硫酸はマウス膵ランゲルハンス島の形態形成やβ細胞増殖,インスリン分泌機能に重要な役割を果たしている (2008)
  • Author(s): 高橋巌, 野口直哉, 那谷耕司, 山田修平, 金岩知之, 水本秀二, 池田崇之, 杉原一司, 浅野雅秀, 吉川雄朗, Nausheen J. Shervani, 宇留野晃, 海野倫明, 菅原一幸, 高澤伸, 岡本宏, 菅原明
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ヘパラン硫酸はマウス膵ランゲルハンス島の形態形成やβ細胞増殖、インスリン分泌機能に重要な役割を果たしている。 (2008)
  • Author(s): 高橋 巌
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] Impaired glucose-induced insulin secretion in FK506-binding protein 12.6-deficient mice. (2008)
  • Author(s): Yoshikawa T, Noguchi N, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A
  • Organizer: The American Diabetes Association 68th Scientific Sessions.
  • Place of Presentation: San Francisco
  • Year and Date: 2008-06-08
• [Presentation] Impaired glucose-induced insulin secretion in FK506-binding protein 12.6-deficient mice. (2008)
  • Author(s): Yoshikawa, T.
  • Organizer: American Diabetes Association 68th Scientific Sessions.
  • Place of Presentation: Moscone Convention Center, San Francisco
  • Year and Date: 2008-06-08
• [Presentation] 膵β細胞特異的糖転移酵素Extl3欠損マウスはβ細胞増殖能低下と耐糖能異常を生じる (2008)
  • Author(s): 高橋巌, 那谷耕司, 野口直哉, 池田崇之, 吉川雄朗, 山内晶世, Nausheen J. Shervani, 宇留野晃, 杉原一司, 浅野雅秀, 海野倫明, 高澤伸, 岡本宏, 菅原明
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Presentation] 膵β細胞特異的糖転移酵素Extl3欠損マウスはβ細胞増殖能低下と耐糖能異常を生じる。 (2008)
  • Author(s): 高橋 巌
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-05-24
• [Presentation] FK506結合蛋白質12.6ノックアウトマウスにおけるグルコース刺激インスリン分泌の低下 (2008)
  • Author(s): 吉川雄朗, 野口直哉, 池田崇之, 高橋巌, Nausheen J. Shervani, 宇留野晃, 山内晶世, 那谷耕司, 高澤伸, 岡本宏, 菅原明
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] FK506結合蛋白質12.6ノックアウトマウスにおけるグルコース刺激インスリン分泌の低下 (2008)
  • Author(s): 吉川雄朗
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-05-23
• [Presentation] Reduced β-cell proliferation and impaired glucose tolerance in β-cell specific Extl3 knockout mice. (2008)
  • Author(s): Takahashi I, Nata K, Noguchi N, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Unno M, Takasawa S, Okamoto H, Sugawara A
  • Organizer: 44th Annual Meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Rome
• [Presentation] Reduced B-cell proliferation and impaired glucose tolerance in B-cell specific Extl3 knockout mice. (2008)
  • Author(s): Takahashi I.
  • Organizer: 44th Annual Meeting of the European Association for the Study of Diabetes
  • Place of Presentation: The Da Vinci Hall, Rome