A role of Tumor Suppressor Fhit Product in Cell Death, Survival and Carcinogenesis

• Project/Area Number: 20590313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kyushu University
• Principal Investigator: 石井 秀始 Kyushu University, 生体防御医学研究所 (10280736)
• Co-Investigator(Kenkyū-buntansha): 三森 功士 九州大学, 生体防御医学研究所, 准教授 (50322748)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 癌抑制遺伝子 / 活性酸素 / ゲノム / 染色体

Research Abstract

More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions include how the cell death of cancer cells are prohibited by deficiency or alterations of FHIT gene and cancer cells would survive in the microenvironment ; the Fhit protein can be phosphorylated though the response to extracellular stimuli. Thus this notion is considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies.

Research Products

• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. (2011)
  • Author(s): Ota, D.Mimori, K.Yokobori, T.Iwatsuki, M.Kataoka, A.Masuda, N.Ishii, H.Ohno, S.M, Mori.
  • Journal Title: Int.J.Oncol. in press[Epub ahead of print]
• [Journal Article] The significance of PITX2 overexpression in human colorectal cancer. (2011)
  • Author(s): Hirose, H.Ishii, H.Mimori, K., et.al
  • Journal Title: Ann Surg Oncol. (in press)
• [Journal Article] STC2 : A Predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma. (2011)
  • Author(s): Kita, Y.Mimori, K.Iwatsuki, M.Yokobori, T.Ieta, K.Tanaka, F.Ishii, H., et.al
  • Journal Title: Ann Surg Oncol. 18(1) Pages: 261-272
• [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma. (2011)
  • Author(s): Nishida, N.Mimori, K.Yokobori, T.Sudo, T.Tanaka, F.Shibata, K.Ishii, H.Doki, Y.Mori, M.
  • Journal Title: Ann.Surg.Oncol. 18(2) Pages: 535-542
• [Journal Article] Clinical significance of ASB9 in human colorectal cancer. (2010)
  • Author(s): Tokuoka, M.Miyoshi, N.Hitora, T.Mimori, K.Tanaka, F.Shibata, K.Ishii, H., et.al
  • Journal Title: Int.J.Oncol. 37(5) Pages: 1105-1111
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. (2010)
  • Author(s): Nishida, N.,Mimori, K.Fabbri, M.Yokobori, T.Sudo, T.Tanaka, F.Shibata, K., Ishii, H.Doki, Y.Mori, M.
  • Journal Title: Clin.Cancer Res.[Epubahead of print] (in press)
• [Journal Article] Serum matrix-metalloproteinase-1 is a bona fide prognostic marker for colorectal cancer. (2010)
  • Author(s): Tahara, K.Mimori, K.Iinuma, H.Iwatsuki, M.Yokobori, T.Ishii, H.Anai, H.Kitano, S.Mori, M.
  • Journal Title: Ann Surg Oncol. 17(12) Pages: 3362-3369
• [Journal Article] Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum.2010 Dec 2. (2010)
  • Author(s): Takahashi, H.Ishii, H.Nishida, N.Okano, M.Kim, H.Yokobori, T.Mimori, K., et.al
  • Journal Title: Ann Surg Oncol.[Epub ahead of print] (in press)
• [Journal Article] FHIT suppresses inflammatory carcinogenic activity by inducing apoptosis in esophageal epithelial cells. (2010)
  • Author(s): Mimori, K.Yokoboro, T.Iwatsuki, M.Ishii, H.Mori, M.
  • Journal Title: J.Nucl.Acid.Invest. (in press)
• [Journal Article] Clinic al significance of miR-21 overexpression in bone marrow from breast cancer cases. (2010)
  • Author(s): Mimori, K.Ota, D.Yokobori, T.Kataoka, A.Masuda, N.Tanaka, F.Ishii, H.Mori, M.
  • Journal Title: J.Nucl.Acid.Invest. (in press)
• [Journal Article] The clinical significance of vimentin-expressing gastric cancer cells in bone marrow. (2010)
  • Author(s): Iwatsuki, M.Mimori, K.Fukagawa, T.Ishii, H.Yokobori, T.Sasako, M.Baba, H.Mori, M.
  • Journal Title: Ann Surg.Oncol. 17(9) Pages: 2526-2533
• [Journal Article] Correlated expression of CD47 and SIRP1 in bone marrow and in peripheral blood predicts recurrence in breast cancer patients. (2010)
  • Author(s): Nagahara, M.Mimori, K.Kataoka, A.Ishii, H., et.al
  • Journal Title: Clin.Cancer Res. 16(18) Pages: 4625-4635
• [Journal Article] Clinical significance of Stanniocalcin 2 as a prognostic marker in gastric cancer. (2010)
  • Author(s): Yokobori, T.Mimori, K.Ishii, H., et.al
  • Journal Title: Ann Surg Oncol. 17(10) Pages: 2601-2607
• [Journal Article] Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells. (2010)
  • Author(s): Nagai, K.Ishii, H., et.al
  • Journal Title: Biochem.Biophys.Res.Commun. 30;395(2) Pages: 258-263
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance. (2010)
  • Author(s): Iwatsuki, M.Mimori, K.Ishii, H., et.al
  • Journal Title: Int.J.Cancer 126 Pages: 1828-1837
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: J.Clin.Invest. 120(9) Pages: 3326-3339
• [Journal Article] Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors. (2010)
  • Author(s): Hirose, H.Ishii, H.Mimori, K., et.al
  • Journal Title: Oncology Report. 23 Pages: 35-43
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Nagai, K.Hoshino, H.Mimori, K., et.al
  • Journal Title: Proc.Natl.Acad.Sci.USA 107(1) Pages: 40-45
• [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: Int.J.Oncol. 36 Pages: 563-568
• [Journal Article] Abnormal expression of PFDN4 in colorectal cancer : a novel marker for prognosis. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: Ann.Surg.Oncol. 17(11) Pages: 3030-3036
• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: J.Surg.Oncol. 101(2) Pages: 156-159
• [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: Ann.Surg.Oncol. 17 Pages: 967-972
• [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et.al
  • Journal Title: Oncology Report. 23 Pages: 505-510
• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. (2010)
  • Author(s): Tanaka, F.Yamamoto, K.Suzuki, S.Inoue, H.Tsurumaru, M.Kajiyama, Y.Kato, H.Igaki, H.Furuta, K.Fijita, H.Tanaka, T.Tanaka, Y.Kawashima, Y.Natsugoe, S.Setoyama, T.Tokudome, S.Mimori, K.Haraguchi, N.Ishii, H.Mori, M.
  • Journal Title: Gut 59 Pages: 1457-1464
• [Journal Article] FHIT suppresses inflammatory carcinogenic activity by inducing apoptosis in esophageal epithelial cells. (2010)
  • Author(s): Mimori, K., Yokoboro, T., Iwatsuki, M., Ishii H., Mori, M.
  • Journal Title: J.Nucl.Acid.Invest. Pages: 2269-77
  • Peer Reviewed
• [Journal Article] Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer. (2010)
  • Author(s): Mimori, K.Tahara, K.Iinuma, H.Iwatsuki, M.Yokobori, T.Ishii, H.Anai, H.Kitano, S.Mori, M.
  • Journal Title: Ann Surg Oncol Pages: 3362-9
  • Peer Reviewed
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi, N., Ishii, H., Mimori, K., Tanaka, F., Ohkuma, M., Kim, H.M., Akita, H., Takiuchi, D., Hatano, H., Nagano, H., Barnard, G., Doki, Y., Mori, M.
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 3326-3339
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells. (2010)
  • Author(s): Miyoshi, N., Ishii, H., Nagai, K.-i., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., Mori, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 107 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance (2010)
  • Author(s): Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M.
  • Journal Title: Int.J.Cancer 126 Pages: 1828-1837
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi, N., Ishii, H., Nagai, K.-i., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., Mori, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 107 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. (2009)
  • Author(s): Hoshino, H.Miyoshi, N.Nagai, K-i.Tomimaru, Y.Nagano, H.Sekimoto, M.Doki, Y.Mori, M.Ishii, H.
  • Journal Title: Biochem.Biophys.Res.Commun. 390(3) Pages: 1061-1065
• [Journal Article] Postoperative complications in elderly patients with colorectal cancer : comparison of open and laparoscopic surgical procedures. (2009)
  • Author(s): Tei, M.Ikeda, M.Haraguchi, N.Takemasa, I.Mizushima, T.Ishii, H., et.al
  • Journal Title: Surg.Laparosc.Endosc.Percutan.Tech. 19(6) Pages: 488-492
• [Journal Article] Abnormal expression of TRIB3 in colorectal cancer : a novel marker for prognosis. (2009)
  • Author(s): Miyoshi, N., Ishii, H.Mimori, K., et.al
  • Journal Title: Br.J.Cancer 101 Pages: 1664-1670
• [Journal Article] RGS16 is a novel marker for prognosis in colorectal cancer. (2009)
  • Author(s): Miyoshi, N.Ishii, H., et.al
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 3507-3514
• [Journal Article] Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer cases. (2009)
  • Author(s): Mimori, K.Kataoka, A.Yamaguchi, H.Masuda, N., Kosaka, Y.Ishii, H.Ohno, S.Mori, M.
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 2035-2041
• [Journal Article] Comprehensive Analysis of the clinical significance of inducing pluripotent stemness-related genes expression in colorectal cancer cells. (2009)
  • Author(s): Saiki, Y.Ishimaru, S.Mimori, K.Takatsuno, Y.Nagahara, M.Ishii, H., et.al
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 2638-2644
• [Journal Article] p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases. (2009)
  • Author(s): Yokobori, T.Mimori, K.Iwatsuki, M.Ishii, H., et.al
  • Journal Title: Cancer Res. 69(9) Pages: 3788-3794
• [Journal Article] Bone marrow and peripheral blood expression of ID1 in human gastric carcinoma patients is a bona fide indicator of lymph node and peritoneal metastasis. (2009)
  • Author(s): Iwatsuki, M.Fukagawa, T.Mimori, K.Nakanishi, H.Ito, S.Ishii, H., et.al
  • Journal Title: Br.J.Cancer 100(12) Pages: 1937-1942
• [Journal Article] Prevention of severe pelvic abscess formation following extended radical surgery for locally recurrent rectal cancer. (2009)
  • Author(s): Uemura, M.Ikeda, M.Sekimoto, M.Haraguchi, N.Mizushima, T.Yamamoto, H.Takemasa, I.Ishii, H.Mori, M.
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 2204-2210
• [Journal Article] Epithelial-mesenchymal transition with expression of SNAI1 induced chemoresistance in colorectal cancer (2009)
  • Author(s): Hoshino, H., Miyoshi, N., Nagai, K-i., Tomimaru, Y., Nagano, H., Sekimoto, M., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Biochem.Biophys.Res.Commun. 390 Pages: 1061-5
  • Peer Reviewed
• [Journal Article] Abnormal expression of TRIB3 in colorectal cancer : a novel marker for prognosis (2009)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., Takatsuno, Y., Kim., H., Hirose, H., Sekimoto, M., Doki, Y., Masaki, M
  • Journal Title: Br.J.Cancer 101 Pages: 1664-1670
  • Peer Reviewed
• [Journal Article] Abnormal expression of TRIB3 in colorectal cancer : a novel marker for prognosis (2009)
  • Author(s): Miyoshi, N., Ishii, H., Sekimoto, M., Doki, Y., Mori.M.
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 3507-3514
  • Peer Reviewed
• [Journal Article] Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer cases (2009)
  • Author(s): Mimori, K., Kataoka, A., Yamaguchi, H., Masuda, N., Kosaka, Y., Ishii, H., Ohno, S., Mori, M.
  • Journal Title: Ann.Surg.Oncol. 16 Pages: 2035-2041
  • Peer Reviewed
• [Journal Article] p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases (2009)
  • Author(s): Yokobori, T.Mimori, K., Iwatsuki, M., Ishii, H., Onoyama, I., Fukagawa, T., Kuwano, H., Nakayama, K.-I.Mori, M
  • Journal Title: Cancer Res. 69 Pages: 3788-94
  • Peer Reviewed
• [Journal Article] Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells. (2008)
  • Author(s): Yamamoto, H.Noura, S.Okami, J.Uemura, M., Takemasa, I.Ikeda M.Ishii, H., et.al
  • Journal Title: Int.J.Mol.Med. 22(6) Pages: 757-761
• [Journal Article] A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. (2008)
  • Author(s): Mimori, K.Fukagawa, T.Kosaka, Y.Ishikawa, K.Iwatsuki, M.Yokobori, T.Hirasaki, S.Takatsuno, Y.Sakashita, H.Ishii, H., et.al
  • Journal Title: An.Surg.Oncol. 15(10) Pages: 2934-2942
• [Journal Article] Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-histidine triad treatment. (2008)
  • Author(s): Mimori, K.Ishii, H., et.al
  • Journal Title: J.Gastroenterol.Hepatorol.23 Suppl.2
• [Journal Article] Fez1/Lzts1 deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis. (2008)
  • Author(s): Baffa, R.Fassan, M.Sevignani, C.Vecchione, A.Ishii, H., et.al
  • Journal Title: Carcinogenesis 29(4) Pages: 846-848
• [Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. (2008)
  • Author(s): Ishii, H.Mimori, K., et.al
  • Journal Title: Cancer Res. 68(10) Pages: 3662-3670
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (2008)
  • Author(s): Ohta, M.Mimori, K.Fukuyoshi, Y.Kita, Y.Motoyama, K.Yamashita, K.Ishii, H., Inoue, H., Mori, M.
  • Journal Title: Br.J.Cancer 98(2) Pages: 410-417
• [Journal Article] Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells. (2008)
  • Author(s): Yamamoto, H., 他
  • Journal Title: Int. T. Mol. Med. 22 Pages: 757-61
  • Peer Reviewed
• [Journal Article] A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. (2008)
  • Author(s): Mimori K, 他
  • Journal Title: Ann. Sure. Oncol. 15 Pages: 2934-42
  • Peer Reviewed
• [Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. (2008)
  • Author(s): Ishii, H., 他
  • Journal Title: Cancer Res. 68 Pages: 3662-70
  • Peer Reviewed
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in esophageal cancer. (2008)
  • Author(s): Ohta, M., 他
  • Journal Title: Br. J. Cancer 98 Pages: 410-7
  • Peer Reviewed
• [Journal Article] Cancer stem cells and chemoradiation resistance. (2008)
  • Author(s): Ishii. H., 他
  • Journal Title: Cancer Science 99 Pages: 1871-1877
  • Peer Reviewed
• [Presentation] 二光子励起顕微鏡を用いた癌細胞の生体イメージング (2011)
  • Author(s): 賀川義規、石井秀始, 他10名
  • Organizer: 第44回制癌剤適応研究会
  • Place of Presentation: 熊本
  • Year and Date: 2011-03-11
• [Presentation] 大腸癌のmicroRNA181a発現による予後解析 (2011)
  • Author(s): 半田理雄、石井秀始, 他9名
  • Organizer: 第44回制癌剤適応研究会
  • Place of Presentation: 日熊本
  • Year and Date: 2011-03-11
• [Presentation] 大腸癌における癌幹細胞 (2011)
  • Author(s): 金浩敏、石井秀始、原口直紹、家田敬輔、田中文明、三森功士, 他7名
  • Organizer: 第74回大腸癌研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-01-21
• [Presentation] がん幹細胞に対する治療戦略 (2011)
  • Author(s): 石井秀始, 他4名
  • Organizer: 第13回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
• [Presentation] 消化器癌幹細胞の研究と治療への展開 (2010)
  • Author(s): 石井秀始, 他5名
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-28
• [Presentation] 大腸癌におけるmicroRNA-372の発現 (2010)
  • Author(s): 山下晋也、石井秀始、三森功士, 他7名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] ES細胞様遺伝子による消化器癌細胞のリプログラミング:遺伝子変異を有する胆管細胞癌の長期培養系における悪性度の検討 (2010)
  • Author(s): 永井健一、石井秀始, 他10名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 大腸癌におけるmicroRNA181a発現の臨床病理学的意義について (2010)
  • Author(s): 半田理雄、石井秀始、田中文明、三森功士, 他8名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 大腸癌におけるLgr5陽性細胞の意義について (2010)
  • Author(s): 高橋秀和、石井秀始、西田尚弘、岡野美穂、金浩敏、横堀武彦、三森功士, 他4名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 消化器癌における再プログラミング化について (2010)
  • Author(s): 三吉範克、石井秀始, 他11名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 消化器癌幹細胞 (2010)
  • Author(s): 石井秀始
  • Organizer: 大腸肛門学会
  • Place of Presentation: 奄美大島
  • Year and Date: 2010-07-02
• [Presentation] 消化器癌幹細胞 (2010)
  • Author(s): 石井秀始
  • Organizer: 大腸肛門学会
  • Place of Presentation: 鹿児島県
  • Year and Date: 2010-07-02
• [Presentation] (2010)
  • Author(s): 森正樹、石井秀始、原口直紹
  • Organizer: 第9回日本再生医療学会総会
  • Year and Date: 2010-03-19
• [Presentation] 臨床病理学的診断を凌駕する、マイクロアレイを用いたDukes B大腸癌における転移予測因子の同定 (2010)
  • Author(s): 三森功士、横堀武彦、飯沼久恵、石井秀始, 他3名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 消化器の癌幹細胞 (2010)
  • Author(s): 石井秀始, 他4名
  • Organizer: 第19回日本癌病態治療研究会
  • Place of Presentation: 東京
• [Presentation] 消化器癌の癌幹細胞研究 (2010)
  • Author(s): 石井秀始, 他14名
  • Organizer: 第19回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
• [Presentation] 消化器の癌幹細胞 (2010)
  • Author(s): 石井秀始, 他5名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 細胞周期静止期にある消化器癌幹細胞の同定と解析 (2010)
  • Author(s): 石井秀始、森正樹
  • Organizer: 第12回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
• [Presentation] 消化器癌幹細胞の制御 (2010)
  • Author(s): 石井秀始, 森正樹
  • Organizer: 第12回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
• [Presentation] 固形癌の癌幹細胞～その現状と展望～ (2009)
  • Author(s): 石井秀始、森正樹
  • Organizer: 第47回日本婦人科腫瘍学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-21
• [Presentation] Gatrtointestinal Cancer Stem Cells (2009)
  • Author(s): 石井秀始, 原口直紹, 森正樹
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 癌幹細胞研究と治療への応用 (2009)
  • Author(s): 森正樹、三吉範克、原口直紹、石井秀始
  • Organizer: 第29回日本分子腫瘍マーカー研究会
  • Place of Presentation: 神戸
  • Year and Date: 2009-09-30
• [Presentation] 消化器癌における癌幹細胞 (2009)
  • Author(s): 石井秀始、森正樹
  • Organizer: 千里ライフサイエンスセミナー「臨床に繋がる癌幹細胞研究」
  • Place of Presentation: 千里
  • Year and Date: 2009-08-25
• [Presentation] 消化器癌の癌幹細胞 (2009)
  • Author(s): 石井秀始, 他2名
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 北海道旭川
  • Year and Date: 2009-07-23
• [Presentation] 大腸癌におけるEMTを制御し造腫瘍能と多分化能を有する遺伝子の臨床的意義と機能解析 (2009)
  • Author(s): 三森功士、横堀武彦、岩槻政晃、石丸神矢、秋吉清百合、永原誠、石井秀始、森正樹
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 北海道旭川
  • Year and Date: 2009-07-23
• [Presentation] 消化器癌の癌幹細胞研究 (2009)
  • Author(s): 森正樹、原口直紹、石井秀始
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-01
• [Presentation] 消化器癌の癌幹細胞 (2009)
  • Author(s): 石井秀始
  • Organizer: 東京工業大学のイノベ-ション研究推進体シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] Gatrtointestinal Cancer Stem Cells. (2009)
  • Author(s): Ishii H., et.al
  • Organizer: 第8回日中がんシンポジウム
  • Place of Presentation: 大阪
• [Presentation] 消化器癌における癌幹細胞の分離と同定 (2009)
  • Author(s): 原口直紹、石井秀始, 他7名
  • Organizer: 第27回日本ヒト細胞学会総会
  • Place of Presentation: 東京
• [Presentation] Gatrtointestinal Cancer Stem Cells. (2009)
  • Author(s): Ishii H., et.al
  • Organizer: The 68th Annual Meeting of Japanese Cancer Association.International Session.
• [Presentation] Identification and characterization of gastrointestinal cancer stem cells. (2009)
  • Author(s): 石井秀始, 森正樹
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] 消化器癌幹細胞の制御 (2009)
  • Author(s): 石井秀始, 他2名
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
• [Presentation] Identification and characterization of gastrointestinal cancerstem cells (2009)
  • Author(s): 石井秀始, 森正樹
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Identification and characterization of gastrointestinal cancer stem cells (2009)
  • Author(s): 石井秀始, 原口直紹, 森正樹
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Loss of FHIT is associated with resistance to chemoradiotherapy in intractable esophageal cancer cases (2008)
  • Author(s): Mimori K., Ishii H., et.al
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Characteristics of Colon Cancer-Initiating Cells. (2008)
  • Author(s): Ishii, H., 他
  • Organizer: The 36th Congress of the International Society of Oncologv & BioMarkers (IS0BM2008).
  • Place of Presentation: Tokyo
• [Book] The Journal of Nucleic Acids Investigation.(Role of microRNAs in solid tumors.) (2011)
  • Author(s): Hamano R., Ishii H., et.al
  • Publisher: Editor-in-Chief : Dr. Muller Fabbri(in press).
• [Book] 腫瘍内科(総説「がん幹細胞を標的とした治療薬の開発」。Clinical Oncology, Mar第7巻,第1号) (2011)
  • Author(s): 石井秀始, 他13名
  • Publisher: 科学評論社
• [Book] Perspective beyond cancer genomics : bioenergetics of cancer stem cells.(Yonsei Med.J.) (2010)
  • Author(s): Ishii H., Doki Y., Mori M.
• [Book] Cancer Sci.(Epithelial-mesenchymal transition in cancer development and its clinical significance.) (2010)
  • Author(s): Iwatsuki M., Mimori K., Yokobori T., Ishii H., et.al.
• [Book] Properties and identification of cancer stem cells : a changing insight into intractable cancer. (2010)
  • Author(s): Miyoshi N., Ishii H., et.al
  • Publisher: Surg Today
• [Book] 『大腸癌FRONTIER』(癌幹細胞の最新知見。Gastrointestinal Cancer Stem Cells.【幹細胞と大腸発癌】。特集大腸癌研究の最新の知見。vol.3, no.3) (2010)
  • Author(s): 石井秀始, 他3名
  • Publisher: メディカルレビュー社
• [Book] 臨床血液総説(日本語)(腫瘍幹細胞研究の消化器癌への展開。Gastrointestinal cancer stem cells。第71回日本血液学会総会シンポジウム) (2010)
  • Author(s): 石井秀始, 他4名
• [Book] 連載企画、腫瘍をめぐるQ&A。Q19活性酸素と癌との関連性について教えてください。「Surgery Frontier」 (2010)
  • Author(s): 石井秀始, 他4名
  • Publisher: メディカルレビュー社
• [Book] 「消化器の癌幹細胞」「Cytometry Research」 (2010)
  • Author(s): 石井秀始, 他8名
• [Book] Cancer Science(Roles of the fragile gene product, Fhit, in oxidative and replicative stress responses.) (2009)
  • Author(s): Okumura H, Ishii H., et.al.
• [Book] Ros production and DNA damage response where does Fhit fit.(Preparation for Cancer Science 2009) (2009)
  • Author(s): Okumura H., Ishii H., et.al
• [Book] Genetic susceptibility to gastrointestinal cancer : Mini-review of the genomewide study. (2009)
  • Author(s): Tokuoka M., Ishii H., Mimori K., et.al
  • Publisher: Ann.Surg.Oncol.
• [Book] 特集抗癌剤の開発-癌幹細胞を標的とした治療戦略。Medical Science Digest(消化器系癌における癌幹細胞。Cancer stem cells in gastrointestinal system。) (2009)
  • Author(s): 石井秀始、森正樹
  • Publisher: ニューサイエンス社
• [Book] 小林がん研究振興財団会誌(固形癌の癌幹細胞研究。「展望(Promising Vistas in Cancer Research」(No.3)) (2009)
  • Author(s): 森正樹、石井秀始
  • Publisher: 癌と化学療法社
• [Book] Cancer Drugs Discovery and Development : Stem Cells and Cancer.(Cancer stem cells : gastrointestinal cancers, Chapter 12. In : the 1st edition book entitled)(Book Editors: Rebecca G. Bagley, MS, and Beverly A. Teicher, PhD. Publisher) (2009)
  • Author(s): Ishii H., Haraguchi N., Ieta, K., Mimori K., Mori M.
  • Publisher: Publisher : Springer Science & Humana Press, Inc.(in press)
• [Book] The role of the tumor suppressor Fhit in cancer-initiating cells.(In : "Regulatory Networks in Stem Cells". "Part V.Disease paradigms and stem cell therapeutics.)(Eds : Drs.V.K. Rajasekhar, M.C.Vemuri.) (2009)
  • Author(s): 石井秀始
  • Publisher: Humana Press/Springer Science-Business Media.
• [Book] Fhit tumor suppressor : guardian of the preneoplastic genome. (2008)
  • Author(s): Pichiorri F, Palumbo T, Suh SS, Okamura H, Trapasso F, Ishii H, Huebner K, Croce CM
  • Publisher: Future Oncol.
• [Book] Cancer stem cells and chemoradiation resistance. (2008)
  • Author(s): Ishii H., Iwatsuki M., Ieta K., Ohta D., Haraguchi N., Mimori K., Mori M.
  • Publisher: Cancer Science
• [Book] Cancer metastasis as disrupted developmental phenotype. (2008)
  • Author(s): Ishii H., Saito T.
  • Publisher: Curr.Genom.
• [Book] Molecular parameters of genome instability : Roles of fragile genes at common fragile sites. (2008)
  • Author(s): Pichiorri F, Ishii H, et.al
  • Publisher: J Cell Biochem.
• [Book] Modulation of DNA damage checkpoint ; patenting and possible application for cancer medicine. (2008)
  • Author(s): Ishikawa, K., Ishii H., Ichimura, K.
  • Publisher: Rec.Pat.DNA Gene Seq.
• [Book] 分子細胞治療(「固形癌患者の末梢血中微量癌細胞の鋭敏なマイクロチップ検出法。書評:Isolation of rare circulating tumor cells in cancer patients by microchip technology.Nature 450, Vol.7, no.4)(Nagrath, S., et al.) (2008)
  • Author(s): 石井秀始、三森功士、森正樹
  • Publisher: (in press)
• [Book] 紀要「未病と抗老化」(グローバルな環境変異原に対応する核内分子機構と疾病制御Vol.17, No.1) (2008)
  • Author(s): 石井秀始
  • Publisher: 財団法人博慈会老人病研究所
• [Book] Fhit and Cancer Initiating Cells."Cell Cycle Control : New Research", as an Expert Commentary of the BOOK.2008.(Nova Science Publishers, Inc.Frank Columbus, President and Editor-in-Chief, Nova Science Publishers) (2008)
  • Author(s): Ishii H., Saito T.
  • Publisher: Inc.New York.
• [Book] How does tumor suppressor FHIT modulate oxidative stress and DNA damage checkpoints in early cancer?(In : "Progress in DNA Damage Research". ChapterVII.Nova Science Publishers, Inc.Frank Columbus, President and Editor-in-Chief, Nova Science Publishers)(Editors : Souta Miura and Shouta Nakano.) (2008)
  • Author(s): Ishii H., Saito T.
  • Publisher: Inc.New York.
• [Book] Recent progress of radiation research : cancer stem cells and ncRNAs. In : "Stem Cell Applications in Diseases". Short Communication.(Nova Science Publishers, Inc. Frank Columbus, President and Editor-in-Chief, Nova Science Publishers)(Editor : Mikkel L.Sorensen.) (2008)
  • Author(s): Ishii H., Saito T.
  • Publisher: Inc.New York.
• [Book] 基礎[Review](ncRNA (miRNA)と癌Vol.9) (2007)
  • Author(s): 石井秀始
  • Publisher: Caner Frontier
• [Book] 分子細胞治療(FHITマウス。連載「モデルマウス」。隔月刊誌) (2007)
  • Author(s): 石井秀始
  • Publisher: 先端医学社
• [Book] (Molecular Target …..).
  • Author(s): Nagai K., Ishii H., Nagano H., Mori M.
  • Publisher: Surgery Today.(in preparation)
• [Book] Fhit and Cancer Initiation.Cell Cycle Control Research in Chaper 5, BOOK.2008.(Nova Science Publishers, Inc. Frank Columbus, President and Editor-in-Chief, Nova Science Publishers)(Editor : K.L. Chen.)
  • Author(s): Ishii H., Saito T.
  • Publisher: Inc.New York.
• [Patent(Industrial Property Rights)] 誘導多能性幹細胞の製造方法 (2010)
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2010-034008
  • Filing Date: 2010-02-18
• [Patent(Industrial Property Rights)] 癌幹細胞の検出方法、及び新規な抗癌剤 (2010)
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2010-043353
  • Filing Date: 2010-02-26
• [Patent(Industrial Property Rights)] 癌幹細胞の機能的標識 (2010)
  • Inventor(s): 森正樹, 石井秀始, 他
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2010-043353
  • Filing Date: 2010-02-26
• [Patent(Industrial Property Rights)] 未分化細胞の識別方法(新名称) (2009)
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2009-241605
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] 癌幹細胞の製造方法(新名称) (2009)
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2009-241322
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] 癌幹細胞の製造方法 (2009)
  • Inventor(s): 森正樹, 石井秀始, 他
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2009-241322
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] 未分化細胞の識別方法 (2009)
  • Inventor(s): 森正樹, 石井秀始, 他
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2009-241605
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] 誘導多能性幹細胞の製造方法 (2009)
  • Inventor(s): 森正樹, 石井秀始, 他
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2010-034008
  • Filing Date: 2009-10-14
• [Patent(Industrial Property Rights)] 細胞レプログラミングの増感法
  • Industrial Property Rights Holder: 国立大学法人大阪大学