A role of Tumor Suppressor Fhit Product in Cell Death, Survival and Carcinogenesis
Project/Area Number |
20590313
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Kyushu University |
Principal Investigator |
石井 秀始 Kyushu University, 生体防御医学研究所 (10280736)
|
Co-Investigator(Kenkyū-buntansha) |
三森 功士 九州大学, 生体防御医学研究所, 准教授 (50322748)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 癌抑制遺伝子 / 活性酸素 / ゲノム / 染色体 |
Research Abstract |
More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions include how the cell death of cancer cells are prohibited by deficiency or alterations of FHIT gene and cancer cells would survive in the microenvironment ; the Fhit protein can be phosphorylated though the response to extracellular stimuli. Thus this notion is considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies.
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Report
(4 results)
Research Products
(130 results)
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[Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab.2010
Author(s)
Nishida, N.,Mimori, K.Fabbri, M.Yokobori, T.Sudo, T.Tanaka, F.Shibata, K., Ishii, H.Doki, Y.Mori, M.
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Journal Title
Clin.Cancer Res.[Epubahead of print] (in press)
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[Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.2010
Author(s)
Tanaka, F.Yamamoto, K.Suzuki, S.Inoue, H.Tsurumaru, M.Kajiyama, Y.Kato, H.Igaki, H.Furuta, K.Fijita, H.Tanaka, T.Tanaka, Y.Kawashima, Y.Natsugoe, S.Setoyama, T.Tokudome, S.Mimori, K.Haraguchi, N.Ishii, H.Mori, M.
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[Journal Article] CD13 is a therapeutic target in human liver cancer stem cells.2010
Author(s)
Haraguchi, N., Ishii, H., Mimori, K., Tanaka, F., Ohkuma, M., Kim, H.M., Akita, H., Takiuchi, D., Hatano, H., Nagano, H., Barnard, G., Doki, Y., Mori, M.
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Journal Title
J.Clin.Invest.
Volume: 120
Pages: 3326-3339
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Peer Reviewed
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[Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells.2010
Author(s)
Miyoshi, N., Ishii, H., Nagai, K.-i., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., Mori, M.
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 107
Pages: 40-45
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Peer Reviewed
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[Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance2010
Author(s)
Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M.
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Journal Title
Int.J.Cancer 126
Pages: 1828-1837
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Peer Reviewed
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[Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells2010
Author(s)
Miyoshi, N., Ishii, H., Nagai, K.-i., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., Mori, M.
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Journal Title
Proc.Natl.Acad.Sci.USA 107
Pages: 40-45
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Peer Reviewed
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[Journal Article] Epithelial-mesenchymal transition with expression of SNAI1 induced chemoresistance in colorectal cancer2009
Author(s)
Hoshino, H., Miyoshi, N., Nagai, K-i., Tomimaru, Y., Nagano, H., Sekimoto, M., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Biochem.Biophys.Res.Commun. 390
Pages: 1061-5
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Peer Reviewed
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[Journal Article] Abnormal expression of TRIB3 in colorectal cancer : a novel marker for prognosis2009
Author(s)
Miyoshi, N., Ishii, H., Mimori, K., Takatsuno, Y., Kim., H., Hirose, H., Sekimoto, M., Doki, Y., Masaki, M
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Journal Title
Br.J.Cancer 101
Pages: 1664-1670
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Peer Reviewed
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[Journal Article] Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer cases2009
Author(s)
Mimori, K., Kataoka, A., Yamaguchi, H., Masuda, N., Kosaka, Y., Ishii, H., Ohno, S., Mori, M.
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Journal Title
Ann.Surg.Oncol. 16
Pages: 2035-2041
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Peer Reviewed
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[Journal Article] p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases2009
Author(s)
Yokobori, T.Mimori, K., Iwatsuki, M., Ishii, H., Onoyama, I., Fukagawa, T., Kuwano, H., Nakayama, K.-I.Mori, M
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Journal Title
Cancer Res. 69
Pages: 3788-94
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Peer Reviewed
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[Journal Article] A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.2008
Author(s)
Mimori, K.Fukagawa, T.Kosaka, Y.Ishikawa, K.Iwatsuki, M.Yokobori, T.Hirasaki, S.Takatsuno, Y.Sakashita, H.Ishii, H., et.al
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Journal Title
An.Surg.Oncol. 15(10)
Pages: 2934-2942
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[Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.2008
Author(s)
Ohta, M.Mimori, K.Fukuyoshi, Y.Kita, Y.Motoyama, K.Yamashita, K.Ishii, H., Inoue, H., Mori, M.
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Journal Title
Br.J.Cancer 98(2)
Pages: 410-417
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[Presentation]2010
Author(s)
森正樹、石井秀始、原口直紹
Organizer
第9回日本再生医療学会総会
Year and Date
2010-03-19
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[Presentation] 消化器癌の癌幹細胞2009
Author(s)
石井秀始, 他2名
Organizer
第18回日本がん転移学会学術集会・総会
Place of Presentation
北海道旭川
Year and Date
2009-07-23
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[Book] Cancer Drugs Discovery and Development : Stem Cells and Cancer.(Cancer stem cells : gastrointestinal cancers, Chapter 12. In : the 1st edition book entitled)(Book Editors: Rebecca G. Bagley, MS, and Beverly A. Teicher, PhD. Publisher)2009
Author(s)
Ishii H., Haraguchi N., Ieta, K., Mimori K., Mori M.
Publisher
Publisher : Springer Science & Humana Press, Inc.(in press)
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