Elucidation of signal transduction systems which are regulated by BHD tumor suppressor protein
| Project/Area Number |
20590316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Juntendo University |
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Principal Investigator |
KOBAYASHI Toshiyuki Juntendo University, 大学院・医学研究科, 准教授 (40260070)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 家族性腫瘍 / 遺伝性腎癌 / 動物モデル / BHD遺伝子 / TSC2遺伝子 / mTORキナーゼ / AMP依存性キナーゼ / サイクリンD1 / 腎癌 / シグナル伝達 / BHD / 細胞周期 / mTOR / folliculin / AMPK / Tsc2 / mTORC1 / Birt-Hogg-Dube症候群 |
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| Research Abstract |
It was found that the suppression of BHD (Birt-Hogg-Dube syndrome gene) tumor suppressor protein expression reduced the amount of mTOR complex (mTORC1) and induces cyclin D1 protein level. It is suggested that the BHD mutation induces dysregulation of a signal transduction system regulating cyclin D1 mRNA level and leads to tumorigenesis through aberrant cell cycle. This regulatory system for cyclin D1 expression may be a novel target to develop therapeutic drug for BHD and other tumor predisposing diseases.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010
Author(s)
Wang L, Kobayashi T, Piao X, Shiono M, Takagi Y, Mineki R, Taka H, Zhang D, Abe M, Sun G, Hagiwara Y, Okimoto K, Matsumoto I, Kouchi M, Hino O
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Journal Title
FEBS Lett 584
Pages: 39-43
Related Report
Peer Reviewed
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[Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.2010
Author(s)
Kunogi M, Kurihara M, Ikegami TS, Kobayashi T, Shindo N, Kumasaka T, Gunji Y, Kikkawa M, Iwakami S, Hino O, Takahashi K, Seyama K
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Journal Title
J Med Genet 47
Pages: 281-287
Related Report
Peer Reviewed
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[Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009
Author(s)
Piao X, Kobayashi T, Wang L, Shiono M, Takagi Y, Sun G, Abe M, Hagiwara Y, Zhang D, Okimoto K, Kouchi M, Matsumoto I, Hino O
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Journal Title
Biochem Biophys Res Commun 389
Pages: 16-21
Related Report
Peer Reviewed
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