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Investigation of epigenetic abnormalities involved in lung cancer progression.

Research Project

Project/Area Number 20590324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

OSADA Hirotaka  Aichi Cancer Center Research Institute, 分子腫瘍学部, 室長 (30204176)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分子腫瘍学 / 癌 / 肺癌 / エピジェネティック / マイクロRNA / 転移 / ASH1
Research Abstract

Lung cancers with neuroendocrine features are usually highly metastatic and aggressive. We investigated the relationship between ASH1 signaling and epigenetic abnormalities in lung cancers, because neuroendocrine features are induced by ASH1. Our findings revealed a novel tumor suppressor candidate gene, which is suppressed by ASH1 signaling and epigenetic abnormalities. We also found ASH1-upregulated miRNA and characterized the epigenetic status of its promoter region. Finally, a tetracycline-inducible ASH1 expression system was established.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (10 results) Remarks (3 results)

  • [Journal Article] let-7 and miR-17-92 : Small-sized major players in lung cancer development.2011

    • Author(s)
      Osada H, et al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 9-17

    • NAID

      10029287990

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LATS2 is a tumor suppressor gene of malignant mesothelioma.2011

    • Author(s)
      Murakami H, et al.
    • Journal Title

      Cancer Research

      Volume: 71 Pages: 873-883

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Profiles of Epigenetic Evolution between Colorectal Cancers with and without Metastasis.2011

    • Author(s)
      Ju HX, et al.
    • Journal Title

      American Journal of Pathology

      Volume: 178 Pages: 1835-1846

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress-Response Pathways.2010

    • Author(s)
      Yanagisawa K, et al.
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 9949-9958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.2010

    • Author(s)
      Huang QM, et al.
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 8407-8416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.2010

    • Author(s)
      Suda K, et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 16 Pages: 5489-5498

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.2010

    • Author(s)
      An B, et al.
    • Journal Title

      International Journal of Cancer.

      Volume: 127 Pages: 2095-2105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms tocytotoxicity of amrubicin in human lung cancer cell lines.2010

    • Author(s)
      Horio Y, et al.
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 66 Pages: 237-243

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A characteristic methylation profile in CpG island methylator phenotype-negative distalcolorectal cancers.2010

    • Author(s)
      An,B., et al
    • Journal Title

      International J.Cancer (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms to cytotoxicity of amrubicin in human lung cancer cell lines.2010

    • Author(s)
      Horio,Y., et al.
    • Journal Title

      Cancer Chemother Pharmacol (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.2009

    • Author(s)
      Goto,Y., et al.
    • Journal Title

      Cancer Research 69

      Pages: 9073-9082

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damaae induction in lune cancers.2009

    • Author(s)
      Ebi,H., et al.
    • Journal Title

      Dncogene 28

      Pages: 3371-3379

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses.2009

    • Author(s)
      Ebi,H., et al.
    • Journal Title

      Cancer Research 69

      Pages: 4027-4035

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.2009

    • Author(s)
      Kawaguchi,K., et al
    • Journal Title

      Carcinogenesis 30

      Pages: 1097-1105

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi H
    • Journal Title

      Cancer Research (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells2009

    • Author(s)
      Kawaguchi K
    • Journal Title

      Carcinogenesis (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada H
    • Journal Title

      Cancer Research 68

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation2008

    • Author(s)
      Yokoyama T
    • Journal Title

      Carcinogenesis 29

      Pages: 2139-2146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas2008

    • Author(s)
      Gao W
    • Journal Title

      Carcinogenesis 29

      Pages: 1901-1910

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2008

    • Author(s)
      Shimizu J
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer2008

    • Author(s)
      Yamada H
    • Journal Title

      Genes Chromosomes and Cancer 47

      Pages: 810-818

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Roles of ASH1-regulated miRNAs in lung cancer development2010

    • Author(s)
      長田啓隆, 他
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌におけるmicroRNA異常2010

    • Author(s)
      長田啓隆
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of ASH1-regulated miRNAs in lung cancer development2010

    • Author(s)
      長田啓隆
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌の転移関連遺伝子CLCP1の機能解析2009

    • Author(s)
      長田啓隆, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of CLCP1 gene in lung cancer progression2009

    • Author(s)
      Osada,H., et al.
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] miR-375 induced by ASH1 plays a role in neuroendocrine differentiation in lungcancers.2009

    • Author(s)
      Nishikawa,E., et al.
    • Organizer
      2009 AACR Annual Meeting
    • Place of Presentation
      米国・デンバー
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規遺伝子ADw1は上皮細胞間接着に関与し、肺癌で高頻度に発現低下する2008

    • Author(s)
      長田啓隆
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ADw1, a novel gene, is frequently inactivated in lung cancer and involved in cell-cell contact2008

    • Author(s)
      Osada H
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌における micro RNAの異常と意義2008

    • Author(s)
      長田啓隆
    • Organizer
      第23回日本肺癌学会ワークショップ
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada H
    • Organizer
      AACR Annual meeting 2008
    • Place of Presentation
      米国 San Diego
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-03.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/300/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/300/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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