| Project/Area Number |
20590325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
|
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
KONDO Yutaka Aichi Cancer Center Research Institute, 分子腫瘍学部, 室長 (00419897)
|
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| Research Collaborator |
安 炳九 愛知県がんセンター(研究所), 分子腫瘍学部, リサーチレジデント
新城 恵子 愛知県がんセンター(研究所), 分子腫瘍学部, 連携大学院生
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子腫瘍学 / エピジェネティクス / 遺伝子制御機構 / ヒストンメチル化 / DNAメチル化 / 発がん / がん抑制遺伝子 / ヒストン修飾 / マイクロアレイ / 悪性胸膜中皮腫 |
|---|
| Research Abstract |
In the current study, to clarify the contribution of epigenetic abnormalities to the human tumorigenesis, we conducted high-throughput analysis of DNA methylation, lysine 27 trimethylation and genetic alterations in human malignancies. Using malignant mesothelioma as a model, we demonstrated a characteristic epigenetic profile of human mesothelioma and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor-suppressor genes in mesothelioma and could serve as diagnostic or prognostic targets.
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