Mechanisms of diseases by chromosomal translocation
Project/Area Number |
20590326
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Research Institute, Shiga Medical Center |
Principal Investigator |
KINOSHITA Kazuo Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員 (50293874)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 分子腫瘍学 / 染色体転座 / 染色体異常 / DNA組換え / 遺伝子間距離 / 染色体テリトリー / がん |
Research Abstract |
Chromosomal Translocations are one of major causes of various diseases including cancer, psychiatric disorders, and congenital anomalies. Understanding these diseases requires a technique to experimentally recapitulate diseases-specific chromosomal translocations. We improved previous methods to enable easier and quicker manipulation of mammalian chromosomes. Using this technique, we demonstrated recapitulations of two-types of cancer-causing chromosomal translocations and induction of intra-chromosomal duplication, deletion, and inversion. In addition, we applied it to measurement of distance between two genetic loci.
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Report
(4 results)
Research Products
(14 results)