| Project/Area Number |
20590328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Shinshu University |
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Principal Investigator |
WAKUI Keiko Shinshu University, 医学部, 助教 (50324249)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Yoshimitsu 信州大学, 医学部, 教授 (70273084)
TANABE Hideyuki 総合研究大学院大学, 先導科学研究科, 准教授 (50261178)
和田 敬仁 信州大学, 医学部, 准教授 (70359727)
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| Research Collaborator |
KAWAMURA Rie 信州大学, 大学院・医学研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞遺伝学 / 3D-FISH解析 / 染色体構造異常 / 遺伝子 / ゲノム / 位置効果 |
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| Research Abstract |
3D-FISH analyses performed to measure the relative positioning of SNRPN and UBE3A genes at 15q11.2 region on each homologous chromosomes 15 within the interphase nucleus of normal B-lymphoblastoid cell lines. The average distances between two genes on each chromosome 15 were 0.32 and 0.60μm. This result suggests the 3D distance between two genes on one of the chromosome 15 seems to be different from on the other chromosome 15 in each nucleus. The minimal distances from the SNRPN genes to the nuclear membrane were 0.6±0.7 and 1.4±0.9μm, and also seems to be different between the homologous chromosomes.
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