Clock genes regulates tumor growth and tumor angiogenesis of human pancreato-biliary cancer.

• Project/Area Number: 20590334
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hirosaki University
• Principal Investigator: KIJIMA Hiroshi Hirosaki University, 大学院・医学研究科, 教授 (90204859)
• Co-Investigator(Renkei-kenkyūsha): SATO Fuyuki 弘前大学, 大学院・医学研究科, 助教 (60400131) ; MOROHASHI Satoko 弘前大学, 大学院・医学研究科, 助教 (90569592)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 癌 / 膵臓 / 胆道 / 時計遺伝子 / 血管新生 / 遺伝子制御

Research Abstract

Pancreato-biliary cancer is one of the most aggressive malignancies of human. Its aggressiveness is thought to be associated with rapid cell growth and resistance to apoptosis (programmed cell death). Clock genes regulate not only circadian rhythm (biological clock) of human bodies, but also cell growth and anti-apoptotic property of the cancer cells. The clock genes play important roles in resistance to apoptosis of the cancer cells treated by anticancer agents or antitumor cytokines.

Research Products

• [Journal Article] PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells. (2011)
  • Author(s): Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y, Kijima H
  • Journal Title: Eur J Cancer. Epub ahead of print
• [Journal Article] Mesenchymal Stromal Cells Promote Tumor Growth Through the Enhancement of Neovascularization. (2011)
  • Author(s): Suzuki K, Sun R, Origuchi M, Kanehira M, Takahata T, Itoh J, Umezawa A, Kijima H, Fukuda S, Saijo Y
  • Journal Title: Mol Med. Epub ahead of print
• [Journal Article] L1 Cell adhesion molecule (L1CAM) expression at the cancer invasive front is a novel prognostic marker of pancreatic ductal adenocarcinoma. (2011)
  • Author(s): Tsutsumi S, Morohashi S, Kudo Y, Akasaka H, Ogasawara H, Ono M, Takasugi K, Ishido K, Hakamada K, Kijima H
  • Journal Title: J Surg Oncol. 103 Pages: 669-673
• [Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. (2011)
  • Author(s): Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y, Kijima H
  • Journal Title: Int J Mol Med. 27 Pages: 491-495
• [Journal Article] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis. (2010)
  • Author(s): Hara S, Kijima H, Okada K, Igarashi Y
  • Journal Title: Biomed Res. 31 Pages: 89-95
  • NAID: 130004903796
• [Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. (2010)
  • Author(s): Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H
  • Journal Title: Genes Cells. 15 Pages: 315-325
• [Journal Article] Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells. (2010)
  • Author(s): Akasaka H, Sato F, Morohashi S, Wu Y, Liu Y, Kondo J, Odagiri H, Hakamada K, Kijima H
  • Journal Title: BMC Cancer. 10 Pages: 548-548
• [Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells (2010)
  • Author(s): Liu Y., Kijima H., et al.
  • Journal Title: Genes to Cells Volume: 15 Pages: 315-325
  • Peer Reviewed
• [Journal Article] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis (2010)
  • Author(s): Hara S., Kijima H., et al.
  • Journal Title: Biomedical Research Volume: 31 Pages: 89-95
  • NAID: 130004903796
  • Peer Reviewed
• [Journal Article] Anti-apoptotic effect of caludin-1 in tamoxifen-treated human breast cancer MCF-7 cells (2010)
  • Author(s): Akasaka H., Kijima H., et al.
  • Journal Title: BMC Cancer Volume: 12
  • Peer Reviewed
• [Journal Article] PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells. (2009)
  • Author(s): Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, Imaizumi T, Kato Y, Kijima H
  • Journal Title: J Biochem. 146 Pages: 833-838
  • NAID: 10026305252
• [Journal Article] Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma. (2009)
  • Author(s): Ohashi M, Kusumi T, Sato F, Kudo Y, Jin H, Akasaka H, Miyamoto K, Toyoki Y, Hakamada K, Kijima
  • Journal Title: Biomed Res. 30 Pages: 79-86
  • NAID: 130004470741
• [Journal Article] Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma. (2009)
  • Author(s): Okada K., Kijima H., et al.
  • Journal Title: Anticancer Research 30 Pages: 53-62
  • NAID: 130004903749
  • Peer Reviewed
• [Journal Article] Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma (2009)
  • Author(s): Ohashi M., Kijima H., et al.
  • Journal Title: Biomedical Research 30 Pages: 79-86
  • NAID: 130004470741
  • Peer Reviewed
• [Journal Article] PERIOD1(PER1)is an anti-apoptotic factor in human pancreatic and hepatic cancer cells (2009)
  • Author(s): Sato F., Kijima H., et al.
  • Journal Title: Journal of Biochemistry 146 Pages: 833-838
  • Peer Reviewed
• [Journal Article] Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells. (2008)
  • Author(s): Kondo J, Sato F, Kusumi T, Liu Y, Motonari O, Sato T, Kijima H
  • Journal Title: Int J Mol Med. 22 Pages: 645-649
• [Journal Article] Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-alpha (2008)
  • Author(s): Suzuki T., and Kijima H., et.al.
  • Journal Title: Biomededical Research 29 Pages: 99-103
  • NAID: 130004724055
  • Peer Reviewed
• [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification (2008)
  • Author(s): Nishi T., and Kijima H., et.al.
  • Journal Title: Anticancer Research 28 Pages: 1627-1631
  • Peer Reviewed
• [Journal Article] Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells (2008)
  • Author(s): Kondo J., and Kijima H., et.al.
  • Journal Title: International Journal of Molecular Medicine 22 Pages: 645-649
  • Peer Reviewed
• [Presentation] Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells. (2010)
  • Author(s): 佐藤冬樹、赤坂治枝、諸橋聡子、Wu Yunyan, 鬼島宏
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-29
• [Presentation] Pro- and anti-apoptotic effects of DEC1/DEC2 in paclitaxel-treated human breast cancer MCF-7 cells. (2010)
  • Author(s): 呉雲燕、佐藤冬樹、諸橋聡子、加藤幸夫、鬼島宏
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-29
• [Presentation] Expression of DEC1 in tumor progression. (2010)
  • Author(s): 佐藤冬樹、劉洋、近藤潤、諸橋聡子、加藤幸夫、鬼島宏
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-29
• [Presentation] Expression of DEC1 in tumor progression (2010)
  • Author(s): 佐藤冬樹、鬼島宏, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-04-29
• [Presentation] 膵癌細胞における細胞接着因子claudin-1と浸潤との関連性の検討 (2010)
  • Author(s): 近藤潤、佐藤冬樹、劉洋、呉雲燕、諸橋聡子、鬼島宏
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] 膵癌細胞のアポトーシスおよび増殖に関わるPERIOD1遺伝子 (2009)
  • Author(s): 佐藤冬樹、永田千姫良、鈴木貴弘、劉洋、楠美智巳、加藤幸夫、鬼島宏
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-02
• [Presentation] BHLH transcription factor DEC2 is involved in the regulation of apoptosis of MCF-7 cells. (2009)
  • Author(s): 劉洋、佐藤冬樹、近藤潤、楠美智巳、加藤幸夫、鬼島宏
  • Place of Presentation: 京都
  • Year and Date: 2009-05-01
• [Presentation] BHLH transcription factor DEC2 negatively regulates va scular endothelial growth factor expression (2008)
  • Author(s): Sato F., and Kijima H., et.al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Remarks] ホームページ等
  • URL: http://www.med.hirosaki-u.ac.jp/~patho2/
• [Remarks] 弘前大学大学院医学研究科病理生命科学講座
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~patho2/
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~patho2/
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~patho2/