Clock genes regulates tumor growth and tumor angiogenesis of human pancreato-biliary cancer.
| Project/Area Number |
20590334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hirosaki University |
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Principal Investigator |
KIJIMA Hiroshi Hirosaki University, 大学院・医学研究科, 教授 (90204859)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Fuyuki 弘前大学, 大学院・医学研究科, 助教 (60400131)
MOROHASHI Satoko 弘前大学, 大学院・医学研究科, 助教 (90569592)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌 / 膵臓 / 胆道 / 時計遺伝子 / 血管新生 / 遺伝子制御 |
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| Research Abstract |
Pancreato-biliary cancer is one of the most aggressive malignancies of human. Its aggressiveness is thought to be associated with rapid cell growth and resistance to apoptosis (programmed cell death). Clock genes regulate not only circadian rhythm (biological clock) of human bodies, but also cell growth and anti-apoptotic property of the cancer cells. The clock genes play important roles in resistance to apoptosis of the cancer cells treated by anticancer agents or antitumor cytokines.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells.2010
Author(s)
Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H
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Journal Title
Genes Cells. 15
Pages: 315-325
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