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Clock genes regulates tumor growth and tumor angiogenesis of human pancreato-biliary cancer.

Research Project

Project/Area Number 20590334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionHirosaki University

Principal Investigator

KIJIMA Hiroshi  Hirosaki University, 大学院・医学研究科, 教授 (90204859)

Co-Investigator(Renkei-kenkyūsha) SATO Fuyuki  弘前大学, 大学院・医学研究科, 助教 (60400131)
MOROHASHI Satoko  弘前大学, 大学院・医学研究科, 助教 (90569592)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords癌 / 膵臓 / 胆道 / 時計遺伝子 / 血管新生 / 遺伝子制御
Research Abstract

Pancreato-biliary cancer is one of the most aggressive malignancies of human. Its aggressiveness is thought to be associated with rapid cell growth and resistance to apoptosis (programmed cell death). Clock genes regulate not only circadian rhythm (biological clock) of human bodies, but also cell growth and anti-apoptotic property of the cancer cells. The clock genes play important roles in resistance to apoptosis of the cancer cells treated by anticancer agents or antitumor cytokines.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 9 results) Presentation (8 results) Remarks (5 results)

  • [Journal Article] PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells.2011

    • Author(s)
      Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y, Kijima H
    • Journal Title

      Eur J Cancer. Epub ahead of print

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mesenchymal Stromal Cells Promote Tumor Growth Through the Enhancement of Neovascularization.2011

    • Author(s)
      Suzuki K, Sun R, Origuchi M, Kanehira M, Takahata T, Itoh J, Umezawa A, Kijima H, Fukuda S, Saijo Y
    • Journal Title

      Mol Med. Epub ahead of print

    • Related Report
      2010 Final Research Report
  • [Journal Article] L1 Cell adhesion molecule (L1CAM) expression at the cancer invasive front is a novel prognostic marker of pancreatic ductal adenocarcinoma.2011

    • Author(s)
      Tsutsumi S, Morohashi S, Kudo Y, Akasaka H, Ogasawara H, Ono M, Takasugi K, Ishido K, Hakamada K, Kijima H
    • Journal Title

      J Surg Oncol. 103

      Pages: 669-673

    • Related Report
      2010 Final Research Report
  • [Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells.2011

    • Author(s)
      Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y, Kijima H
    • Journal Title

      Int J Mol Med. 27

      Pages: 491-495

    • Related Report
      2010 Final Research Report
  • [Journal Article] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.2010

    • Author(s)
      Hara S, Kijima H, Okada K, Igarashi Y
    • Journal Title

      Biomed Res. 31

      Pages: 89-95

    • NAID

      130004903796

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells.2010

    • Author(s)
      Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H
    • Journal Title

      Genes Cells. 15

      Pages: 315-325

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells.2010

    • Author(s)
      Akasaka H, Sato F, Morohashi S, Wu Y, Liu Y, Kondo J, Odagiri H, Hakamada K, Kijima H
    • Journal Title

      BMC Cancer. 10

      Pages: 548-548

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells2010

    • Author(s)
      Liu Y., Kijima H., et al.
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 315-325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis2010

    • Author(s)
      Hara S., Kijima H., et al.
    • Journal Title

      Biomedical Research

      Volume: 31 Pages: 89-95

    • NAID

      130004903796

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptotic effect of caludin-1 in tamoxifen-treated human breast cancer MCF-7 cells2010

    • Author(s)
      Akasaka H., Kijima H., et al.
    • Journal Title

      BMC Cancer

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells.2009

    • Author(s)
      Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, Imaizumi T, Kato Y, Kijima H
    • Journal Title

      J Biochem. 146

      Pages: 833-838

    • NAID

      10026305252

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma.2009

    • Author(s)
      Ohashi M, Kusumi T, Sato F, Kudo Y, Jin H, Akasaka H, Miyamoto K, Toyoki Y, Hakamada K, Kijima
    • Journal Title

      Biomed Res. 30

      Pages: 79-86

    • NAID

      130004470741

    • Related Report
      2010 Final Research Report
  • [Journal Article] Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma.2009

    • Author(s)
      Okada K., Kijima H., et al.
    • Journal Title

      Anticancer Research 30

      Pages: 53-62

    • NAID

      130004903749

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma2009

    • Author(s)
      Ohashi M., Kijima H., et al.
    • Journal Title

      Biomedical Research 30

      Pages: 79-86

    • NAID

      130004470741

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PERIOD1(PER1)is an anti-apoptotic factor in human pancreatic and hepatic cancer cells2009

    • Author(s)
      Sato F., Kijima H., et al.
    • Journal Title

      Journal of Biochemistry 146

      Pages: 833-838

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells.2008

    • Author(s)
      Kondo J, Sato F, Kusumi T, Liu Y, Motonari O, Sato T, Kijima H
    • Journal Title

      Int J Mol Med. 22

      Pages: 645-649

    • Related Report
      2010 Final Research Report
  • [Journal Article] Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-alpha2008

    • Author(s)
      Suzuki T., and Kijima H., et.al.
    • Journal Title

      Biomededical Research 29

      Pages: 99-103

    • NAID

      130004724055

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification2008

    • Author(s)
      Nishi T., and Kijima H., et.al.
    • Journal Title

      Anticancer Research 28

      Pages: 1627-1631

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells2008

    • Author(s)
      Kondo J., and Kijima H., et.al.
    • Journal Title

      International Journal of Molecular Medicine 22

      Pages: 645-649

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells.2010

    • Author(s)
      佐藤冬樹、赤坂治枝、諸橋聡子、Wu Yunyan, 鬼島宏
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Pro- and anti-apoptotic effects of DEC1/DEC2 in paclitaxel-treated human breast cancer MCF-7 cells.2010

    • Author(s)
      呉雲燕、佐藤冬樹、諸橋聡子、加藤幸夫、鬼島宏
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of DEC1 in tumor progression.2010

    • Author(s)
      佐藤冬樹、劉洋、近藤潤、諸橋聡子、加藤幸夫、鬼島宏
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of DEC1 in tumor progression2010

    • Author(s)
      佐藤冬樹、鬼島宏, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膵癌細胞における細胞接着因子claudin-1と浸潤との関連性の検討2010

    • Author(s)
      近藤潤、佐藤冬樹、劉洋、呉雲燕、諸橋聡子、鬼島宏
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵癌細胞のアポトーシスおよび増殖に関わるPERIOD1遺伝子2009

    • Author(s)
      佐藤冬樹、永田千姫良、鈴木貴弘、劉洋、楠美智巳、加藤幸夫、鬼島宏
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] BHLH transcription factor DEC2 is involved in the regulation of apoptosis of MCF-7 cells.2009

    • Author(s)
      劉洋、佐藤冬樹、近藤潤、楠美智巳、加藤幸夫、鬼島宏
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2010 Final Research Report
  • [Presentation] BHLH transcription factor DEC2 negatively regulates va scular endothelial growth factor expression2008

    • Author(s)
      Sato F., and Kijima H., et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.hirosaki-u.ac.jp/~patho2/

    • Related Report
      2010 Final Research Report
  • [Remarks] 弘前大学大学院医学研究科病理生命科学講座

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.hirosaki-u.ac.jp/~patho2/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.hirosaki-u.ac.jp/~patho2/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.hirosaki-u.ac.jp/~patho2/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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