| Project/Area Number |
20590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
HATAKEYAMA Kinta University of Miyazaki, 医学部, 講師 (60325735)
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| Co-Investigator(Kenkyū-buntansha) |
MARUTSUKA Kosuke 宮崎大学, 医学部, 准教授 (00239154)
SATO Yuichiro 宮崎大学, 医学部, 助教 (90347055)
IMAMURA Takuro 宮崎大学, 医学部, 准教授 (60203329)
TSURUDA Toshihiro 宮崎大学, 医学部, 助教 (10389570)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈硬化 / 血栓症 / 病理学 / 心筋梗塞 / OPG / RANKL system / Osteoprotegerin / RANKL / アテローム血栓症 / 動脈硬化症 / 臨床病理学的検討 / 免疫組織化学 / 動脈血栓モデル / 臨床病理当的検討 / フローチャンバー法 / 血小板凝集 |
|---|
| Research Abstract |
(Purpus)Osteoprotegerin(OPG) is a decoy receptor for Receptor activator of NF-kB(RANKL), and act as RANK antagonist. In this study, the role of OPG/RANKL system in the pathogenesis of atherothrombosis was investigated. Using directional atherectomy(DCA) samples of angina pectoris patients(n=220), aspirated thrombi from coronary arteries of acute myocardial infarction(AMI) patients(n=100) and coronary arteries(n=60) from autopsy samples, we demonstrated that OPG/RANKL was overexpressed in the atherosclerotic lesions, and involved in the pathogenesis of atherothrombosis/acute coronary syndromes.
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