The role of OPG/RANKL system in the pathogenesis of atherothrombosis
| Project/Area Number |
20590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
HATAKEYAMA Kinta University of Miyazaki, 医学部, 講師 (60325735)
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| Co-Investigator(Kenkyū-buntansha) |
MARUTSUKA Kosuke 宮崎大学, 医学部, 准教授 (00239154)
SATO Yuichiro 宮崎大学, 医学部, 助教 (90347055)
IMAMURA Takuro 宮崎大学, 医学部, 准教授 (60203329)
TSURUDA Toshihiro 宮崎大学, 医学部, 助教 (10389570)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈硬化 / 血栓症 / 病理学 / 心筋梗塞 / OPG / RANKL system / Osteoprotegerin / RANKL / アテローム血栓症 / 動脈硬化症 / 臨床病理学的検討 / 免疫組織化学 / 動脈血栓モデル / 臨床病理当的検討 / フローチャンバー法 / 血小板凝集 |
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| Research Abstract |
(Purpus)Osteoprotegerin(OPG) is a decoy receptor for Receptor activator of NF-kB(RANKL), and act as RANK antagonist. In this study, the role of OPG/RANKL system in the pathogenesis of atherothrombosis was investigated. Using directional atherectomy(DCA) samples of angina pectoris patients(n=220), aspirated thrombi from coronary arteries of acute myocardial infarction(AMI) patients(n=100) and coronary arteries(n=60) from autopsy samples, we demonstrated that OPG/RANKL was overexpressed in the atherosclerotic lesions, and involved in the pathogenesis of atherothrombosis/acute coronary syndromes.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Plasma Pentraxin 3, but not High-sensitivity C-reactive Protein, is a Useful Inflammatory Biomarker for Predicting Cognitive Impairment in Elderly Hypertensive Patients.2010
Author(s)
Yano Y, Matsuda S, Hatakeyama K, Sato Y,, Imamura T, Shimada K, Kodama T, Kario K, Asada Y
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Journal Title
J Gerontol A Biol Sci Med Sci 65
Pages: 547-552
Related Report
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[Journal Article] Reciprocal contribution of pentraxin 3 and c-reactive protein to obesity and metabolic syndrome.2010
Author(s)
Ogawa T, Kawano Y, Imamura T, Kawakita K, Sagara M, Matsuo T, Kakitsubata Y, Ishikawa T, Kitamura K, Hatakeyama K, Asada Y, Kodama T
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Journal Title
Obesity (Silver Spring) 18
Pages: 1871-1874
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[Journal Article] Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.2009
Author(s)
Harada-Shiba M, Takamisawa I, Miyata K, Ishii T, Nishiyama N, Itaka K, Kangawa K, Yoshihara F, 浅田祐士郎, 畠山金太, Nagaya N, Kataoka K
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Journal Title
Mol Ther 17
Pages: 1180-1186
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[Presentation] Enhanced expression of podoplanin in advanced atherosclerotic plaques is involved in coronary thrombus formation in acute myocardial infarction.2008
Author(s)
Hatakeyama K, Kato Y, Kaneko MK, Ishikawa T, Nishihira K, Shibata Y, K.Inoue S, Ozaki Y, Asada Y
Organizer
14^<th> World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions.
Place of Presentation
Tronto, Canada
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