Mucin gene expression mechanism related to a new classification of pancreatobiliary neoplasms
| Project/Area Number |
20590345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kagoshima University |
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Principal Investigator |
YONEZAWA Suguru Kagoshima University, 医歯学総合研究科, 教授 (10175002)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Michiyo 鹿児島大学, 医歯学総合研究科, 講師 (60315405)
GOTO Masamichi 鹿児島大学, 医歯学総合研究科, 客員研究員 (80325779)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 消化器 / 唾液腺 / 膵癌 / 膵管内乳頭粘液性腫瘍 / 粘液産生胆管腫瘍 / DNAメチル化 / ムチン / ヒストン化学修飾 / マイクロRNA / 転写後翻訳阻害 / MUC1 / MUC2 / MUC4 / MUC5AC / ヒストン修飾 / MUC16 / 肝内胆管癌 / 予後因子 / エピジェネティクス |
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| Research Abstract |
The combination of MUC1, MUC2, MUC4 and MUC5AC expression is useful for early detection and evaluation of the potential for malignancy of pancreatobiliary neoplasms. Regarding the mechanism of mucin expression, we have recently reported that expression of the mucin genes is regulated epigenetically in cancer cell lines. A future translational research into mucin gene expression mechanisms, including epigenetics, may provide new tools for early and accurate detection of human pancreatobiliary neoplasms.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells.2010
Author(s)
Yamada N, Nishida Y, Yokoyama S, Tsutsumida H, Houjou I, Kitamoto S, Goto M, Higashi M, Yonezawa S
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Journal Title
J Hepatobiliary Pancreat Sci 17(6)
Pages: 844-854
NAID
Related Report
Peer Reviewed
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