Novel role of ALOX5 (L22) in the control of antibody production

• Project/Area Number: 20590347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Sapporo Medical University
• Principal Investigator: ICHIMIYA Shingo Sapporo Medical University, 保健医療学部, 教授 (30305221)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Alox5 / 慢性炎症 / ナイーブB細胞 / メモリーB細胞 / 濾胞ヘルパーT細胞 / 免疫トレランス / アレルギー / 感染症 / 悪性リンパ腫 / 液性免疫 / リンパ球分化 / 自己免疫疾患 / ALOX5 / アラキドン酸5-リポキシゲナーゼ(ALOX5) / 抗体産生機構 / B細胞分化 / 脂質メディエーター / Toll様受容体 / B細胞抗原受容体

Research Abstract

We have previously reported L22 mAb with which human primary resting B cells and other immune cells of lymphoid follicles are well defined. In this study, we first identifiedL22 Ag as arachidonate 5-lipoxyganase (Alox5) and our experimental results illustrated the novel role of Alox5 during the process of specific antibody production by managing naive and memory B cells as well as follicular helper T cells in vivo. Because Alox5 is a key enzyme giving lipid mediators like leukotrienes, further investigations focusing on metabolome may provide new insights into the mechanisms of innate and adaptive immune responses and the pathogenesis of allergic and chronic inflammatory disorders (Nagashima T, et al. American Journal of Pathology, 2011).

Research Products

• [Journal Article] Anti-CADM-140 antibody positive juvenile dermatomyositis with rapidly progressive interstitial lung disease and cardiac involvement. (2011)
  • Author(s): Sakurai N, Nagai K, Tsutsumi H, Ichimiya S.
  • Journal Title: J Reaumatol. in press(有)
• [Journal Article] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. (2011)
  • Author(s): Nagashima T, Ichimiya S, Kikuchi T, Saito Y, Matsumiya H, Ara S, Koshiba S, Zhang J, Hatate C, Tonooka A, Kubo T, Ye RC, Hirose B, Shirasaki H, Izumi T, Takami T, Himi T, Sato N.
  • Journal Title: Am J Pathol. 178 Pages: 222-232
  • Peer Reviewed
• [Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients. (2011)
  • Author(s): Kameshima H, Tsuruma T, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Ichimiya S, Kanaseki T, Iwayama Y, Sato N, Hirata K.
  • Journal Title: Cancer Sci. Epub ahead of print 10.1111/j.1349-7006 Pages: 1918-1918
  • NAID: 10029294487
  • Peer Reviewed
• [Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells. (2011)
  • Author(s): Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N.
  • Journal Title: Toxicol Appl Pharmacol. 250 Pages: 29-38
  • Peer Reviewed
• [Journal Article] Anti-CADM-140 antibody positive juvenile dermatomyositis with rapidly progressive interstitial lung disease and cardiac involvement. (2011)
  • Author(s): Sakurai N, Ichimiya S, et al.
  • Journal Title: J Reumatol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Immunogenic enhancement and clinical effect by type-1 interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients. (2011)
  • Author(s): Kameshima H, Ichimiya S, et al.
  • Journal Title: Cancer Sci. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. (2011)
  • Author(s): Nagashima T, Ichimiya S, et al.
  • Journal Title: Am J Pathol. Volume: 178 Pages: 222-232
  • Peer Reviewed
• [Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α viadistinct NF-κB pathways in human nasal epithelial cells. (2011)
  • Author(s): Ohkuni T, Ichimiya S, et al.
  • Journal Title: Toxicol Appl Pharmacol. Volume: 250 Pages: 29-38
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells. (2010)
  • Author(s): Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
  • Journal Title: Histochem Cell Biol. 133 Pages: 339-48
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells. (2010)
  • Author(s): Kamekura R, Ichimiya S, et al.
  • Journal Title: Histochem Cell Biol. Volume: 133 Pages: 339-348
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells (2010)
  • Author(s): Kamekura R., et al
  • Journal Title: Histochem Cell Biol. 133 Pages: 339-348
  • Peer Reviewed
• [Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells. (2009)
  • Author(s): Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
  • Journal Title: Biochem Biophys Res Commun. 389 Pages: 543-549
  • Peer Reviewed
• [Journal Article] Molecular pathological approaches to human tumor immunology. (2009)
  • Author(s): Sato N, Hirohashi Y, Tsukahara T, Kikuchi T, Sahara H, Kamiguchi K, Ichimiya S, Tamura Y, Torigoe T.
  • Journal Title: Pathol Int. 59 Pages: 205-1
  • NAID: 10027379604
  • Peer Reviewed
• [Journal Article] Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells. (2009)
  • Author(s): Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, Kimura S, Yokoyama S, Takano Y, Kikuchi T, Sato N.
  • Journal Title: Biochem Biophys Res Commun. 379 Pages: 765-770
  • Peer Reviewed
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. (2009)
  • Author(s): Tsukahara T, Kimura S, Ichimiya S, Torigoe T, Kawaguchi S, Wada T, Yamashita T, Sato N.
  • Journal Title: Cancer Sci. 100 Pages: 47-53
  • NAID: 10025141244
  • Peer Reviewed
• [Journal Article] Molecular pathological approaches to human tumor immunology (2009)
  • Author(s): Sato N., et al
  • Journal Title: Pathol Int. 59 Pages: 205-217
  • Peer Reviewed
• [Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells (2009)
  • Author(s): Ogasawara N., et al
  • Journal Title: Biochem Biophys Res Commun. 389 Pages: 543-549
  • Peer Reviewed
• [Journal Article] Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells (2009)
  • Author(s): Tonooka A., et al
  • Journal Title: Biochem Biophys Res Commun. 379 Pages: 765-770
  • Peer Reviewed
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2009)
  • Author(s): Tsukahara T., et al
  • Journal Title: Cancer Sci. 100 Pages: 47-53
  • Peer Reviewed
• [Journal Article] 症例解説-リンパ節 マントル細胞リンパ腫の病理組織診断 (2009)
  • Author(s): 一宮慎吾
  • Journal Title: 病理と臨床 27 Pages: 1094-1095
• [Journal Article] Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells (2009)
  • Author(s): Tonooka A, et al.
  • Journal Title: Biochem Biophys Res Commun. 379 Pages: 766-770
  • Peer Reviewed
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osfeosarcoma (2009)
  • Author(s): Tsukahara T, et al.
  • Journal Title: Cancer Sci. 100 Pages: 47-53
  • Peer Reviewed
• [Journal Article] p63 induces CD4^+ T-cell chemoattractant TARC/CCL17 in human epithelial cells. (2008)
  • Author(s): Kubo T, Ichimiya S, Tonooka A, Nagashima T, Kikuchi T, Sato N.
  • Journal Title: J Interferon Cytokine Res. 28 Pages: 725-32
  • Peer Reviewed
• [Journal Article] Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma. (2008)
  • Author(s): Tsukahara T, Kawaguchi S, Torigoe T, Kimura S, Murase M, Ichimiya S, Wada T, Kaya M, Nagoya S, Ishii T, Tatezaki S, Yamashita T, Sato N.
  • Journal Title: Cancer Sci. 99 Pages: 368-75
  • NAID: 10024002681
  • Peer Reviewed
• [Journal Article] Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors. (2008)
  • Author(s): Koshiba S, Ichimiya S, Nagashima T, Tonooka A, Kubo T, Kikuchi T, Himi T, Sato N.
  • Journal Title: J Pathol. 214 Pages: 75-84
  • Peer Reviewed
• [Journal Article] p63 induces CD4(+) T-cell chemoattractant TARC/CCL17 in human epithelial cells (2008)
  • Author(s): Kubo T, et al.
  • Journal Title: J Interferon Cytokine Res. 28 Pages: 725-732
  • Peer Reviewed
• [Journal Article] Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors (2008)
  • Author(s): Koshiba s, et al.
  • Journal Title: J Pathol. 214 Pages: 75-84
  • Peer Reviewed
• [Presentation] 肝細胞癌との鑑別に苦慮したyolk sac tumorの一例 (2010)
  • Author(s): 足立靖、一宮慎吾, 他
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 札幌医科大学における「死亡時画像診断による教育支援プログラム」の取り組みについて (2010)
  • Author(s): 佐藤太志、一宮慎吾, 他
  • Organizer: 第46回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-20
• [Presentation] Arachidonate 5-lipoxygenase regulates primary resting B cells and follicular B helper T cells in adaptive humoral immune responses. (2010)
  • Author(s): Nagashima T, Ichimiya S, et al.
  • Organizer: The 7th International Symposium of Tonsils and Mucosal Barriers of the Upper Airways.
  • Place of Presentation: Asahikawa
  • Year and Date: 2010-07-08
• [Presentation] 新しい世紀の病理解剖(日本学術会議シンポジウム) (2010)
  • Author(s): 兵頭秀樹、一宮慎吾, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] Arachidonate 5-lipoxygenase regulates primary resting B cells and follicular B helper T cells in adaptive humoral immune responses. (2010)
  • Author(s): 長島勉, 一宮慎吾, 松宮弘, 荒志保子, 久保輝文, 佐藤昇志, 氷見徹夫
  • Organizer: The 7th International Symposium of Tonsils and Mucosal Barriers of the Upper Airways.
  • Place of Presentation: Asahikawa, Japan
• [Presentation] p63は上皮細胞のTARC/CCL17産生を調節する (2010)
  • Author(s): 久保輝文、一宮慎吾、菊地智樹、佐藤昇志
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 新たな甲状腺乳頭癌特異的バイオマーカーSNX5の意義とその臨床応用 (2010)
  • Author(s): 荒志保子、一宮慎吾、菊地智樹、松宮弘、高野善英、外岡暁子、今信一郎、長谷川匡、氷見徹夫、佐藤昇志
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 新しい世紀の病理解剖 (2010)
  • Author(s): 兵頭秀樹、佐藤大志、晴山雅人、長谷川匡、佐藤昇志、一宮慎吾、菊地智樹、澤田典均
  • Organizer: 第99回日本病理学会総会シンポジウム(後援:日本学術会議)
  • Place of Presentation: 東京
• [Presentation] 死亡時撮像画像と解剖所見の融合画像の作成ならびに学生(研修医)実習教材作成・実施に関する研究 (2010)
  • Author(s): 兵頭秀樹、晴山雅人、長谷川匡、佐藤昇志、澤田典均、一宮慎吾、佐藤大志、菊地智樹
  • Organizer: 第69回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] 特別講演B細胞由来脂質メディエーターによるヘルパーT細胞の機能分化制御-L22抗原の同定とその機能解析から (2009)
  • Author(s): 一宮慎吾
  • Organizer: 第89回北海道医学大会病理分科会(第42回北海道病理談話会)
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-12
• [Presentation] Arachidonate 5-lipoxygenase affordes cellular responses of helper T-cells. (2009)
  • Author(s): 一宮慎吾, 長島勉, 菊地智樹, 松宮弘, 荒志保子, 氷見徹夫, 佐藤昇志
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Cancer, Immunology and Photonics Science. (2009)
  • Author(s): Sato N, Hirohashi Y, Tsukahara T, Ichimiya S, Tamura Y, Torigoe T
  • Organizer: CIF-10.
  • Place of Presentation: Chitose, Japan
• [Presentation] A novel thyroid cancer specific marker : immunohistochemistry analysis and biological implication of oncogene. (2009)
  • Author(s): Kikuchi T, Ichimiya S, Ara S, Matsumiya H, Nagashima T, Takano Y, Tonooka A, Hasegawa T, Sato N.
  • Organizer: The 55th Autumn Congress of Japanese Society of Pathology International poster session.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Midwinter Seminar臨床免疫学の未来:Scythe/BAT3は骨肉腫抗原PBFに誘導される細胞死を制御する (2009)
  • Author(s): 塚原智英、木村重治、一宮慎吾、川口哲、鳥越俊彦、嘉野真允、和田卓郎、山下敏彦、佐藤昇志
  • Organizer: 第32回日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] Scythe/BAT3 regulates AIF-dependent apoptotic cell deat hinduced by PBF in human osteosarcoma (2009)
  • Author(s): 塚原智英、木村重治、一宮慎吾、鳥越俊彦、嘉野真允、和田卓郎、川口哲、山下敏彦、佐藤昇志
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] A novel marker specific for detecting thyroid cancer ; immunohistochemical analysis and biological implication. (2009)
  • Author(s): 菊地智樹、一宮慎吾、長島勉、外岡暁子、高野善英、長谷川匡、氷見徹夫、佐藤昇志
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 特別講演B細胞由来脂質メディエーターによるヘルパーT細胞の機能分化制御-L22抗原の同定とその機能解析から (2009)
  • Author(s): 一宮慎吾
  • Organizer: 第89回北海道医学大会病理分科会・第42回北海道病理談話会
  • Place of Presentation: 札幌
• [Presentation] 新たな甲状腺特異的なバイオマーカーの生物学的意義とその臨床応用 (2009)
  • Author(s): 菊地智樹、一宮慎吾、長島勉、高野善英、外岡暁子、今信一郎、長谷川匡、氷見徹夫、佐藤昇志
  • Organizer: 第89回北海道医学大会病理系分科会・第42回北海道病理談話会
  • Place of Presentation: 札幌
• [Presentation] Scythe/BAT3は骨肉腫抗原PBFに誘導されるapoptosis-inducing factor依存的な骨肉腫の細胞死を制御する (2009)
  • Author(s): 塚原智英、木村重治、川口哲、一宮慎吾、嘉野真允、鳥越俊彦、佐藤昇志、山下敏彦
  • Organizer: 第42回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 横浜
• [Presentation] Scythe/BAT3はPBFに誘導されるAIF依存的な骨肉腫の細胞死を制御する (2009)
  • Author(s): 塚原智英、木村重治、一宮慎吾、鳥越俊彦、嘉野真允、和田卓郎、山下敏彦、佐藤昇志
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 新たな甲状腺特異的バイオマーカーの生物学的意義とその臨床応用 (2009)
  • Author(s): 菊地智樹、一宮慎吾、長島勉、外岡暁子、長谷川匡、氷見徹夫、佐藤昇志
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 5-LO関連脂質メディエーターによる濾胞ヘルパーT細胞の誘導 (2009)
  • Author(s): 長島勉、一宮慎吾、斉藤由幸、菊地智樹、高見剛、氷見徹夫、佐藤昇志
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 死亡時画像診断による教育支援プログラム (2009)
  • Author(s): 佐藤大志、兵頭秀樹、一宮慎吾、秋葉英成、玉川光春、兵頭かずさ、長谷川匡、佐藤昇志、澤田典均、晴山雅人
  • Organizer: 第68回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
• [Presentation] B細胞由来脂質メディエーターによるヘルパーT細胞の機能分化制御機構 (2009)
  • Author(s): 一宮慎吾, 他
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
• [Presentation] A novel thyroid cancer specific marker : immunohistochemistry analysis and biological implication of oncogene (2009)
  • Author(s): 菊地智樹, et al
  • Organizer: 第55回日本病理学会秋期特別総会 International session
  • Place of Presentation: 東京
• [Presentation] 5-LO関連脂質メディエーターによる濾胞BヘルパーT細胞の誘導 (2009)
  • Author(s): 長島勉, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 新たな甲状腺バイオマーカーの生物学的意義とその臨床応用 (2009)
  • Author(s): 菊地智樹, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 抗体産生の成熟とその分子メカニズム : アラキドン酸代謝酵素5-リポキシゲナーゼによる静止期B細胞の制御機構 (2008)
  • Author(s): 長島勉
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-01
• [Presentation] Scythe/BAT3は骨肉腫抗原PBFに誘導されるアポトーシスを制御する (2008)
  • Author(s): 塚原智英
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 5-リポキシゲナーゼ関連脂質メディエーターによる抗体産生応答の制御機構 (2008)
  • Author(s): 長島勉
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: ホテル日航金沢
  • Year and Date: 2008-05-17
• [Presentation] 病理診断講習会 : マントル細胞リンパ腫の病理組織診断 (2008)
  • Author(s): 一宮慎吾
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: ホテル日航金沢
  • Year and Date: 2008-05-17
• [Presentation] Arachidonate 5-lipoxygenase supports the function of resting B cells. (2008)
  • Author(s): 長島勉, 一宮慎吾, 斉藤由幸, 菊地智樹, 氷見徹夫, 高見剛, 佐藤昇志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Scythe/BAT3は骨肉腫抗原PBFに誘導されるアポトーシスを制御する (2008)
  • Author(s): 塚原智英、木村重治、一宮慎吾、鳥越俊彦、川口哲、和田卓郎、山下敏彦、佐藤昇志
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 5-LO関連脂質のメディエーターによる抗体産生応答の制御機構 (2008)
  • Author(s): 長島勉、一宮慎吾、斉藤由幸、菊地智樹、氷見徹夫、佐藤昇志
  • Organizer: 第88回北海道医学大会病理系分科会・第341回北海道病理談話会
  • Place of Presentation: 札幌
• [Presentation] ヒト骨肉腫におけるパピローマウイルス結合因子により誘導されたアポトーシス性細胞死のScythe/BAT3による制御 (2008)
  • Author(s): 塚原智英、木村重治、一宮慎吾、鳥越俊彦、川口哲、和田卓郎、山下敏彦、佐藤昇志
  • Organizer: 第12回基盤的癌免疫研究会総会
  • Place of Presentation: 大宮
• [Presentation] 5-リポキシゲナーゼ関連脂質メディエーターによる抗体産生応答の制御機構 (2008)
  • Author(s): 長島勉、一宮慎吾、斉藤由幸、菊地智樹、氷見徹夫、佐藤昇志
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] Scythe/BAT3はPBFに誘導される骨肉腫の細胞死を制御する (2008)
  • Author(s): 塚原智英、木村重治、一宮慎吾、鳥越俊彦、川口哲、和田卓郎、山下敏彦、佐藤昇志
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 診断講習会.マントル細胞リンパ腫の病理組織診断 (2008)
  • Author(s): 一宮慎吾
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 金沢
• [Book] バイオ医薬の開発技術とシーズ(がんペプチド免疫治療)第30章 (2009)
  • Author(s): 佐藤昇志、廣橋良彦、塚原智英、田村保明、一宮慎吾、鳥越俊彦
  • Publisher: シーエムシー出版
• [Book] オートプシー・イメージング読影ガイド(大友邦監修、分担執筆) (2009)
  • Author(s): 兵頭秀樹、一宮慎吾、長谷川匡
  • Publisher: 文光堂
• [Book] 症例解説-リンパ節マントル細胞リンパ腫の病理組織診断.病理と臨床.27 (2009)
  • Author(s): 一宮慎吾
• [Book] バイオ医薬の開発技術とシーズ.第30章 がんペプチド免疫治療 (2009)
  • Author(s): 佐藤昇志, 他
  • Total Pages: 384
  • Publisher: シーエムシー出版
• [Book] オートプシー・イメージング読影ガイド (2009)
  • Author(s): 兵頭秀樹, 他
  • Total Pages: 190
  • Publisher: 文光堂
• [Remarks] 札幌医科大学病理学第一講座ホームページ
  • URL: http://web.sapmed.ac.jp/patho1/
• [Patent(Industrial Property Rights)] 腫瘍マーカーおよびその利用 (2010)
  • Inventor(s): 一宮慎吾、外岡暁子、菊地智樹、佐藤昇志
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2010-04-07