| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have previously reported L22 mAb with which human primary resting B cells and other immune cells of lymphoid follicles are well defined. In this study, we first identifiedL22 Ag as arachidonate 5-lipoxyganase (Alox5) and our experimental results illustrated the novel role of Alox5 during the process of specific antibody production by managing naive and memory B cells as well as follicular helper T cells in vivo. Because Alox5 is a key enzyme giving lipid mediators like leukotrienes, further investigations focusing on metabolome may provide new insights into the mechanisms of innate and adaptive immune responses and the pathogenesis of allergic and chronic inflammatory disorders (Nagashima T, et al. American Journal of Pathology, 2011).
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