Pivotal role of Pin1 in rheumatoid arthritis pathogenesis

• Project/Area Number: 20590348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: AOKI Ichiro Yokohama City University, 医学研究科, 教授 (00184028)
• Co-Investigator(Kenkyū-buntansha): NAGASHIMA Yoji 横浜市立大学, 医学研究科, 准教授 (10217995) ; NAGAHAMA Kiyotaka 横浜市立大学, 医学部, 助教 (00336538) ; SAITO Tomoyuki 横浜市立大学, 医学研究科, 教授 (30170517) ; RYO Akihide 横浜市立大学, 医学研究科, 教授 (20363814)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 骨 / 関節 / 筋肉 / 皮膚 / 感覚器 / 関節リウマチ / Pin1 / 滑膜 / リン酸化 / NFκB / C/EBP-β

Research Abstract

Pin1 expression was significantly higher in RA-ST than in OA-ST. The expression of MMP-1, MMP-3, and PCNA was also significantly elevated in RA-ST. Double immunofluorescent staining revealed colo-calization of Pin1 and p65 in the nuclei of RA-ST. Positive correlation with Pin1 and C/EBP-β(a transcription factor of IL6)was also indicated. These results suggest that Pin1 may be involved in the pathogenesis of RA binding with p65 to activate the proteins MMP-1, MMP-3, and PCNA. Therefore, Pin1 may play a pivotal role in the pathogenesis of RA.

Research Products

• [Journal Article] Possible involvement of peptidylprolyl isomerase Pin1 in rheumatoid arthritis. (2011)
  • Author(s): Nagaoka A, Takizawa N, Takeuchi R, Inaba Y, Saito I, Nagashima Y, Saito T, Aoki I
  • Journal Title: Pathol Int 61(2) Pages: 59-66
  • NAID: 10031185050
• [Journal Article] Thymic alterations in GM2 gangliosidoses model mouse. (2010)
  • Author(s): Kanzaki S, Yamaguchi A, Yamaguchi K, Kojima Y, Koumitsu N, Nagashima Y, Na-gahama K, Ehara M, Hirayasu Y, Ryo A, Aoki I, Yamanaka S
  • Journal Title: PLoS One 5(8)
• [Journal Article] A duodenal mucosal lesion coming from pancreatic arteriovenous malformation. (2010)
  • Author(s): Kato S, Kobayashi N, Kubota K, Kirikoshi H, Watanabe S, Ogawa M, Inamori M, Shi-mamura T, Tomeno W, Nakajima A, Takeda K, Endo I, Nagashima Y, Aoki I
  • Journal Title: Gastroin-testinal Endoscopy 71(7) Pages: 1299-1300
• [Journal Article] The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracyc-line-based neoadjuvant chemotherapy. (2010)
  • Author(s): Kawachi K, Sasaki T, Murakami A, Ishikawa T, Kito A, Ota I, Shimizu D, Nozawa A, Nagashima Y, Machinami R, Aoki I
  • Journal Title: Pathol Res Pract 206(3) Pages: 156-162
• [Journal Article] Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog. (2010)
  • Author(s): Kobayashi N, Suzuki K, Murakami H, Kagawa E, Aoki I, Nagashima Y
  • Journal Title: J Vet Diagn Invest 22(6) Pages: 983-987
• [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, Oshiro H, Kanzaki S, Ya-maguchi A, Yamanaka S, Furuya M, Miura S, Kanno H, Nagashima Y, Aoki I, Nagahama K
  • Journal Title: Nephrol Dial Transplant 25(12) Pages: 3884-3890
• [Journal Article] High expression of the atypical protein kinase C λ/ι in gastric cancer is promising prognostic factor for re-currence. (2010)
  • Author(s): Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Endo I, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Nagashima Y, Ohno S
  • Journal Title: Ann Surg Oncol 17(1) Pages: 81-88
• [Journal Article] Thymic alterations in GM2 gangliosidoses model mouse. (2010)
  • Author(s): Kanzaki S, et al.
  • Journal Title: PLoS One Volume: 5(8)
  • Peer Reviewed
• [Journal Article] Aduodenal mucosal lesion coming from pancreatic arteriovenous malformation. (2010)
  • Author(s): Kato S, et al
  • Journal Title: Gastrointestinal Endoscopy Volume: 71(7) Pages: 1299-1300
  • Peer Reviewed
• [Journal Article] The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy. (2010)
  • Author(s): Kawachi K, et al.
  • Journal Title: Pathol Res Pract Volume: 206(3) Pages: 156-162
  • Peer Reviewed
• [Journal Article] Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog. (2010)
  • Author(s): Kobayashi N, et al.
  • Journal Title: J Vet Diagn Invest Volume: 22(6) Pages: 983-987
  • Peer Reviewed
• [Journal Article] Anovel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, et al.
  • Journal Title: Nephrol Dial Transplant Volume: 25(12) Pages: 3884-3890
  • Peer Reviewed
• [Journal Article] High expression of the atypical protein kinase C λ/ι in gastric cancer is promising prognostic factor for recurrence. (2010)
  • Author(s): Takagawa R, et al.
  • Journal Title: Ann Surg Oncol Volume: 17(1) Pages: 81-88
  • Peer Reviewed
• [Journal Article] Identification of NPC2 protein as in-teraction molecule with C2 domain of human Nedd4L. (2009)
  • Author(s): Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, Aoki I, Morinaga H, Tamura K, Toya Y, Uchino K, Umemura S.
  • Journal Title: Biochem Biophys Res Commun 388(2) Pages: 290-296
• [Journal Article] Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag. (2009)
  • Author(s): Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, Perrem K, Aoki I, Morikawa Y, Yamamoto N.
  • Journal Title: FEBS Lett 583(8) Pages: 1243-1250
• [Journal Article] Specificity of splenopancreatic field abnormality in trisomy 13 syndrome : Macroscopic and histological analysis in 21 autopsy cases. (2009)
  • Author(s): Gomi K, Sato Y, Tanaka M, Ijiri R, Kato K, Aoki I, Tanaka Y.
  • Journal Title: Pathol Int 59(3) Pages: 147-151
  • NAID: 10027379395
• [Journal Article] Epithelioid angiomyolipoma of the kidney. (2009)
  • Author(s): Kato I,Inayama Y, Yamanaka S, Ohshiro H, Gomi K, Shirai S, Aoki I, Uemura H, Miyoshi Y, Kubota Y, Yao M, Nagashima Y.
  • Journal Title: Pathol Int 59(1) Pages: 38-43
  • NAID: 10027378955
• [Journal Article] Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L (2009)
  • Author(s): Araki N, et al
  • Journal Title: Biochem Biophys Res Commun 388(2) Pages: 290-296
  • Peer Reviewed
• [Journal Article] Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag (2009)
  • Author(s): Nishi M, et al
  • Journal Title: FEBS Lett 583(8) Pages: 1243-1250
  • Peer Reviewed
• [Journal Article] Specificity of splenopancreatic field abnormality in trisomy 13 syndrome : Macroscopic and histological analysis in 21 autopsy cases (2009)
  • Author(s): Gomi K, et al
  • Journal Title: Pathol Int 59(3) Pages: 147-151
  • Peer Reviewed
• [Journal Article] Epithelioid angiomyolipoma of the kidney (2009)
  • Author(s): Kato I, et al
  • Journal Title: Pathol Int 59(1) Pages: 38-43
  • Peer Reviewed
• [Journal Article] Lung cysts in Birt-Hogg-Dube syndrome : histopathological characteristics and aberrant sequence repeats (2009)
  • Author(s): Koga S, et al
  • Journal Title: Pathol Int 59(10) Pages: 720-728
  • Peer Reviewed
• [Journal Article] III. Angiogenesis : complexity of tumor vasculature and microenvironment (2009)
  • Author(s): Furuya M, et al
  • Journal Title: Curr Pharm Des. 15(16) Pages: 1854-1867
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Nagashima Y, et.al
  • Journal Title: Pathology and molecular biology of renal neoplasms. : recent advances and impacts on pathological classification. Molecular mechanism and Morphology in Cancer(Nakamura M(eds.))(Bentham Science Publishers E-Book) Pages: 12-38
• [Journal Article] Specificity of splenopancreatic field abnormality in trisomy 13 syndrome : Macroscopic and histological analysis in 21 autopsy cases. (2009)
  • Author(s): Gomi K, Aoki I, et al.
  • Journal Title: Pathol Int. 59(3) Pages: 147-151
  • NAID: 10027379395
  • Peer Reviewed
• [Journal Article] Low-intensity pulsed ultrasound activates the phosphatidyli-nositol 3 kinase/Akt pathway and stimu-lates the growth of chondrocytes in three-dimensional cultures : a basic science study. (2008)
  • Author(s): Takeuchi R, Ryo A, Komitsu N, Miku-ni-Takagaki Y, Fukui A, Takagi Y, Shi-raishi T, Morishita S, Yamazaki Y, Kumagai K, Aoki I, Saito T
  • Journal Title: Arthritis Res Ther 10(4)
• [Journal Article] Collecting duct carcinoma of the kidney : an immunohis-tochemical evaluation of the use of an-tibodies for differential diagnosis. (2008)
  • Author(s): Kobayashi N, Matsuzaki O, Shirai S, Aoki I, Yao M, Nagashima Y
  • Journal Title: Hum Pathol 39(9) Pages: 1350-1359
• [Journal Article] The over-expression and altered localization of the atypical protein kinase C λ/ι in breast correlates with the pathological type of these tumors. (2008)
  • Author(s): Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, Inayama Y, Aoki I, Ohno S, Shimada H
  • Journal Title: Hum Pathol 39(6) Pages: 824-831
• [Journal Article] Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures : a basic science study. (2008)
  • Author(s): Takeuchi R, Aoki I, et al.
  • Journal Title: Arthritis Res Ther. 10(4)
  • Peer Reviewed
• [Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates intracellular trafficking and stability of HIV-1 Gag. (2008)
  • Author(s): Ryo A, Aoki I, et al.
  • Journal Title: Proc Natl Acad Sci USA. 105(1) Pages: 249-299
  • Peer Reviewed
• [Journal Article] Collecting duct carcinoma of the kidney : an immunohistochemical evaluation of the use of antibodies for differential diagnosis. (2008)
  • Author(s): Kobayashi N, Aoki I, et al.
  • Journal Title: Hum Pathol. 39(9) Pages: 1350-1359
  • Peer Reviewed
• [Journal Article] Pathophysiology of placentation abnormalities in pregnancy-induced hypertension. (2008)
  • Author(s): Furaya M, Aoki I, et al.
  • Journal Title: Vasc Health Risk Manag. 4(6) Pages: 1301-1313
  • Peer Reviewed
• [Journal Article] The overexpression and altered localization of the atypical protein kinase C λ/τ in breast correlates with the pathological type of these tumors. (2008)
  • Author(s): Kojima Y, Aoki I, et al.
  • Journal Title: Hum Pathol. 39(6) Pages: 824-831
  • Peer Reviewed
• [Presentation] Distinct expression patterns of CXCR3 variants in tumor and tu-mor-associated inflammatory diseases of the ovary. (2010)
  • Author(s): 古屋充子, 宮城悦子, 平原史樹, 宮城洋平, 稲山嘉明, 太田一郎, 上大介, 長嶋洋治, 青木一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] aPKC and IL-6 expression in prostate cancer tissues. (2010)
  • Author(s): 石黒斉, 秋本和憲, 長嶋洋治, 加川絵理子, 佐々木毅, 佐野仁勇, 高川亮, 佐々木和教, 藤浪潔, 青木一郎, 大野茂男, 窪田吉信, 上村博司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Distinct expression patterns of CXCR3 variants in tumor and tumor-associated inflammatory diseases of the ovary. (2010)
  • Author(s): 古屋充子, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] 卵巣腫瘍におけるINF-γ誘導性ケモカイン受容体CXCR3バリアントの解析 (2010)
  • Author(s): 古屋充子, 米山朋那, 宮城悦子, 田中玲子, 上大介, 長濱清隆, 長嶋洋治, 宮城洋平, 稲山嘉明, 青木一郎
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-28
• [Presentation] 多発性骨髄腫に合併した好酸球性多発性筋炎の剖検例 (2010)
  • Author(s): 大城久, 小野響子, 平沙代子, 海野俊徳, 渡邉眞一郎, 山中正二, 中山崇, 長嶋洋治, 長濱清隆, 村上あゆみ, 青木一郎, 稲山嘉明
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] 胃癌におけるaPKCλ/ιの高発現は再発の危険因子である (2010)
  • Author(s): 長嶋洋治, 山中正二, 村上あゆみ, 稲山嘉明, 青木一郎
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] 横浜市立大学におけるバイオバンク室の運営と課題 (2010)
  • Author(s): 稲山嘉明, 山中正二, 村上あゆみ, 中山崇, 大城久, 海野俊徳, 小野響子, 平沙代子, 矢澤卓也, 下山田博明, 奥寺康司, 長嶋洋治, 古屋充子, 長濱清隆, 北村均, 青木一郎
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] Magnet activated cell sorting (MACS)を用いた糸球体上皮細胞の単離 (2010)
  • Author(s): 村上あゆみ, 潘勤雅, 大城久, 山中正二, 古屋充子, 長嶋洋治, 青木一郎, 長濱清隆
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] Birt-Hogg-Dube症候群と判明した多発性肺嚢胞の病理学的特徴 (2010)
  • Author(s): 古屋充子, 古賀俊輔, 高橋葉子, 田中玲子, 廣島健三, 岡本龍郎, 吉野一郎, 青木一郎, 中谷行雄
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] 胃癌におけるaPKC λ/ιの高発現は再発の危険因子である (2010)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] GM2ガングリオシドーシスの中枢神経系における炎症反応メカニズムの解明 (2009)
  • Author(s): 山口章, 幸光範子, 神崎誠一, 鈴木京子, 青木一郎, 山中正二
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Presentation] GM2ガングリオシドーシスにおける末梢免疫システムの異常 (2009)
  • Author(s): 神崎誠一, 山口章, 山口佳代子, 小島良績, 鈴木京子, 高井俊行, 青木一郎, 山中正二
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Presentation] GM2ガングリオシドーシスの中枢神経系における炎症反応メカニズムの解明 (2009)
  • Author(s): 山口章, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] M2ガングリオシドーシスにおける末梢免疫システムの異常 (2009)
  • Author(s): 神崎誠一, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Expression of CXCR3 variant in ovarian neoplasms. (2009)
  • Author(s): Furuya M, Miyagi E, Hirahara F, Miyagi Y, Inayama Y, Ota I, Kami D, Nagashima Y, Aoki I.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-03
• [Presentation] Expression of CXCR3 variant in ovarian neoplasms (2009)
  • Author(s): Furuya M, et al
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Pathophysiology of the lung cysts caused by BHD mutation in Birt-Hogg-Dube syndrome patients. (2009)
  • Author(s): 古賀俊輔, 古屋充子, 吉野一郎, 廣島健三, 青木一郎, 中谷行雄
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-02
• [Presentation] Pathophysiology of the lung cysts caused by BHD mutation in Birt-Hogg-Dube syndrome patients (2009)
  • Author(s): 古賀俊輔, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] The overexpression and altered localization of the atypical protein kinase C λ/τ in breast cancers (2009)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2009-08-27
• [Presentation] ヒト前立腺癌細胞と脂肪細胞との相互作用について (2009)
  • Author(s): 上大介, 渡邊昌俊, 長嶋洋治, 青木一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-03
• [Presentation] WT1遺伝子のexon10のナンセンス変異を認め腎移植に至った1例 (2009)
  • Author(s): 村上あゆみ, 長濱清隆, 原田知典, 伊藤秀一, 寺西純一, 江中牧子, 田辺美樹子, 河内香江, 佐々木毅, 野澤昭典, 古屋充子, 長嶋洋治, 青木一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-03
• [Presentation] 卵巣腫瘍における血管作動性ケモカイン受容体CXCR3とそのリガンドの発現解析 (2009)
  • Author(s): 米山朋那, 古屋充子, 宮城悦子, 平原史樹, 宮城洋平, 太田一郎, 西川朱實, 長嶋洋治, 青木一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-03
• [Presentation] ヒト前立腺癌細胞と脂肪細胞との相互作用について (2009)
  • Author(s): 上大介, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] WT1遺伝子のexon10のナンセンス変異を認め腎移植に至った1例 (2009)
  • Author(s): 村上あゆみ, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] 卵巣腫瘍における血管作動性ケモカイン受容体CXCR3とそのリガンドの発現解析 (2009)
  • Author(s): 米山朋那, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] Collecting duct carcinoma of the kidney. An immu-nohistochemical study of 17 cases. (2009)
  • Author(s): 長嶋洋治, 松嵜理, 青木一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-02
• [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察 (2009)
  • Author(s): 古賀俊輔, 古屋充子, 高橋陽子, 山口淳志, 田中玲子, 安福和弘、吉野一郎, 廣島健三, 青木一郎, 中谷行雄
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-02
• [Presentation] Collecting duct carcinoma of the kidney. An immunohistochemical study of 17 cases (2009)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察 (2009)
  • Author(s): 古賀俊輔, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] Sandhoff病モデルマウス脳におけるオートファージの検討 (2008)
  • Author(s): 鈴木京子、都甲崇、山口章、神崎誠一、幸光範子、勝頼大海、内門大丈、青木一郎、山中正二、平安良雄
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: ポートアイランド(神戸)
  • Year and Date: 2008-12-12
• [Presentation] Rasmussen脳炎と膜性腎症を合併した選択的IgA欠損症の1男児例. (2008)
  • Author(s): 村上あゆみ, 青木一郎, 他
  • Organizer: 第24回日本病理学会秋期特別総会
  • Place of Presentation: 松山
  • Year and Date: 2008-11-20
• [Presentation] Collecting duct carcinoma of the kidney. An immunohis-tochemical study for differential diag-nosis. (2008)
  • Author(s): 長嶋洋治, 青木一郎
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2008-11-14
• [Presentation] Collecting duct carcinoma of the kidney. An immunohistochemical study for differential diagnosis. (2008)
  • Author(s): 長嶋洋治, 青木一郎.
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-14
• [Presentation] 前立腺癌骨転移を予測する新しいバイオマーカーp65/RelA-リン酸化スレオニン245抗体 (2008)
  • Author(s): 佐々木毅, 梁明秀, 上村博司, 寺西諄一, 三好康秀, 佐野仁勇, 藤浪潔, 仙賀裕, 青木一郎
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋(学会優秀演題)
  • Year and Date: 2008-10-30
• [Presentation] 前立腺癌骨転移を予測する新しいバイオマーカーp65/RelA-リン酸化スレオニン245抗体 (2008)
  • Author(s): 佐々木毅, 青木一郎.
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] Collecting duct carcinoma of the kidney ; an immunohistochemical evaluation of17cases. (2008)
  • Author(s): Nagashima Y, Aoki I, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Implication of CXC-chemokines and their receptors for proinflammatory microenvironments of ovarian neoplasms. (2008)
  • Author(s): Furuya M, Suyama T, Usui H, Tanaka N, Shozu M, Miyagi E, Hirahara F, Nagashima Y, Aoki I
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2008-10-28
• [Presentation] Implication of CXC-chemokines and their receptors for proinflammatory microenvironments of ovarian neoplasms. (2008)
  • Author(s): Furuya M, Aoki I, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Epithelioid angiomyolipoma. A report of three cases. (2008)
  • Author(s): 長嶋洋治, 大城久, 山中正二, 青木一郎, 稲山嘉明
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: ホテル日航(金沢)
  • Year and Date: 2008-05-16
• [Presentation] The status of aPKCλ/τ in breast cancer correlates with the pathologic types. (2008)
  • Author(s): 長嶋洋治, 青木一郎, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Presentation] Epithelioid angiomyolipoma. A report of three cases. (2008)
  • Author(s): 長嶋洋治, 青木一郎, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Book] Pathology and mo-lecular biology of renal neoplasms. recent advances and impacts on patho-logical classification. Nakamura M (eds.). Molecular mechanism and Morphology in Cancer. (2009)
  • Author(s): Nagashima Y, Kobayashi N, Kagawa E, Aoki I, Inayama Y, Yao M.
  • Publisher: Bentham Science Publishers E-Book
• [Book] RCCの分類-変遷と現状-.冨田善彦,金山博臣,植村天受,篠原信雄(編),Year book of RCC 2008 (2008)
  • Author(s): 長嶋洋治, 青木一郎, 稲山嘉明, 矢尾正祐
  • Publisher: メジカルレビュー社
• [Book] RCCの分類-変遷と現状- (2008)
  • Author(s): 長嶋洋治, 青木一郎, 他
  • Publisher: メジカルレビュー社
• [Remarks] ホームページ等
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