| Project/Area Number |
20590348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
AOKI Ichiro Yokohama City University, 医学研究科, 教授 (00184028)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Yoji 横浜市立大学, 医学研究科, 准教授 (10217995)
NAGAHAMA Kiyotaka 横浜市立大学, 医学部, 助教 (00336538)
SAITO Tomoyuki 横浜市立大学, 医学研究科, 教授 (30170517)
RYO Akihide 横浜市立大学, 医学研究科, 教授 (20363814)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨 / 関節 / 筋肉 / 皮膚 / 感覚器 / 関節リウマチ / Pin1 / 滑膜 / リン酸化 / NFκB / C/EBP-β |
|---|
| Research Abstract |
Pin1 expression was significantly higher in RA-ST than in OA-ST. The expression of MMP-1, MMP-3, and PCNA was also significantly elevated in RA-ST. Double immunofluorescent staining revealed colo-calization of Pin1 and p65 in the nuclei of RA-ST. Positive correlation with Pin1 and C/EBP-β(a transcription factor of IL6)was also indicated. These results suggest that Pin1 may be involved in the pathogenesis of RA binding with p65 to activate the proteins MMP-1, MMP-3, and PCNA. Therefore, Pin1 may play a pivotal role in the pathogenesis of RA.
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