| Project/Area Number |
20590351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
DOBASHI Yoh Jichi Medical University, 医学部, 准教授 (90231456)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Syunsuke 自治医科大学, 医学部, 教授 (10245037)
YANAGAWA Takashi (KITAGAWA Masatoshi) 群馬大学, 医学部, 助教 (50294971)
柳川 天志 群馬大学, 医学部, 助教 (40400725)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Hirochika 山梨大学, 医学部・附属病院, 助手 (00374166)
SATO Eiiti 山梨大学, 医学工学総合研究部, 助教 (80293455)
OOI Akishi 金沢大学, 医学系研究科, 教授 (50160411)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 呼吸器 / 縦隔 / 肺癌 / EGFR / 遺伝子変異 / Akt / mTOR / S6 kinase / 遺伝子増幅 / ポリソミー / 骨軟部肉腫 / リンパ節転移 / 骨軟部腫瘍 / シグナル伝達 / Pirh2 / 分子標的療法 |
|---|
| Research Abstract |
The involvement of epidermal growth factor receptor (EGFR) cascade was analyzed in lung carcinomas and in soft tissue sarcoma. Overexpression/activation of EGFR was observed in 37% and constitutive activation of cascade was found in 11%. Mutation of EGFR was observed in 24% and associated with cell proliferation and metastasis. Increase of AKT genes were found in 45% with reciprocal relation against increase of EGFR gene. In sarcoma, mTOR activation was associated with morphogenesis in tumors of neural and skeletal muscle origin.
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