| Project/Area Number |
20590353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
OKAYASU Isao Kitasato University, 医学部, 名誉教授 (20014342)
|
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Tsutomu 北里大学, 医学部, 講師 (90316943)
MIKAMI Tetuo 北里大学, 医学部, 准教授 (90286352)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 慢性炎症 / 発がん / 間質細胞 / 上皮細胞 / 潰瘍性大腸炎 / 粘膜リモデリング / olfactomedin-4 / petoxiredoxin-1 / myofibroblast / NF-kB / GRIM-19 / aoptosis / retinoic acid / 発癌 / ゲノミックス / プロテオミックス / 慢性臓器炎 / 細胞間相互作用 |
|---|
| Research Abstract |
As organ-specific chronic inflammation-carcinoma sequence, we have analyzed ulcerative colitis (UC)-colorectal carcinoma system, and shown alterations of crosstalk between mucosal crypt epithelia and stromal cells, with decrease of subepithelial myofibroblasts and acceleration of genomic instability of interstitial cells, as well as mucosal remodeling, relating to tumorigenesis.
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