Mechanisms of infection of Helicobacter pylori in human.

• Project/Area Number: 20590354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: YAMADA Taketo Keio University, 医学部, 准教授 (60230463)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ピロリ菌 / パイエル板 / 胃炎 / 胃潰瘍 / リンパ腫 / 樹状細胞 / Helicobactor Pylori / coccoid / 特発性血小板減少症 / MALTリンパ腫 / in situ hybridization / Helicobactor pylori / coccold

Research Abstract

Helicobacter pylori(HP) causes gastritis and gastric ulcer, and then induces gastric carcinoma and MALToma. We examined whether coccoid type HP was transmitted in Peyer patches. The localization of HP in Peyer patches of the infectee was detected as a spherical bacterial body. In the ITP and Sjogren's syndrome case, the bacterial body was not found. These results may indicate that Peyer patches is important in a gain of cellular immunity against HP and coccoid type HP may be done phagocytosis by dendritic cells in Peyer patches.

Research Products

• [Journal Article] Overexpression of leucine-rich repeat-containing Gprotein-coupled receptor 5 in colorectal cancer (2010)
  • Author(s): Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, Kitajima M, Kitagawa Y, Sakamoto M
  • Journal Title: Cancer Science 101 Pages: 1731-1737
  • NAID: 10026595102
  • Peer Reviewed
• [Journal Article] Innate production of T_H2 cytokines by adipose tissue-associated c-Kit^+Sca-1^+ lymphoid cells (2010)
  • Author(s): Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Furusawa J, Ohtani M, Fujii H, Koyasu S
  • Journal Title: Nature 463 Pages: 540-544
  • Peer Reviewed
• [Journal Article] Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. (2010)
  • Author(s): Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, Kitajima M, Kitagawa Y, Sakamoto M
  • Journal Title: Cancer Science Volume: 101 Pages: 1731-1737
  • NAID: 10026595102
  • Peer Reviewed
• [Journal Article] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. (2009)
  • Author(s): Nishida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Inukai T, Sugita K, Ikeda Y, Morimoto C
  • Journal Title: Biochem Biophys Res Commun. 382 Pages: 57-62
  • Peer Reviewed
• [Journal Article] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells (2009)
  • Author(s): Nishida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Inukai T, Sugita K, Ikeda Y, Morimoto C
  • Journal Title: Biochem Biophys Res Commun 382 Pages: 57-62
  • Peer Reviewed
• [Journal Article] Altered cellular immunity in transgenic mice with T cell specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI), a regulator of Rho GTPases. (2008)
  • Author(s): Kondoh K,Nakata Y, Yamaoka T, Itakura M, Hayashi M, Yamada K, Hata J, Yamada T
  • Journal Title: International Immunology 20 Pages: 1299-1311
  • Peer Reviewed
• [Journal Article] Altered cellular immunity in transgenic mice with T cell specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI), a regulator of Rho GTPases. (2008)
  • Author(s): Kondoh K, Nakata Y, Yamaoka T, Itakura M, Hayashi M, Yamada K, Hata J, Yamada T
  • Journal Title: International Immunology 20 Pages: 1299-1311
  • Peer Reviewed
• [Journal Article] Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis (2008)
  • Author(s): Kuwabara Y, Yamada T, Yamazaki K, Du W, Banno M, Aoki D, Sakamoto M
  • Journal Title: Cancer Science 99 Pages: 1933-1939
  • NAID: 10024011784
  • Peer Reviewed
• [Journal Article] Reconstitution of Schwannian stroma in neuroblastomas using human bone marrow stromal cells (2008)
  • Author(s): Du W, Hozumi N, Sakamoto M, Hata J, Yamada T
  • Journal Title: American Journal Pathology 173 Pages: 1153-1164
  • Peer Reviewed
• [Presentation] Innate production of T_H2 cytokines by adipose tissue-associated c-Kit^+Sca-1^+ lymphoid cells. (2010)
  • Author(s): Moro K., Yamada T., Tanabe M., Takeuchi T., Ikawa T., Kawamoto H., Furusawa J., Ohtani M., Fujii H., Koyasu S.
  • Organizer: The 14^<th>. International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Innate production of T_H2 cytokines by adipose tissue-associated c-Kit^+Sca-1^+ lymphoid cells. (2010)
  • Author(s): K.Moro, T.Yamada, M.Tanabe, T.Takeuchi, T.Ikawa, H.Kawamoto, J.Furusawa, M.Ohtani, H.Fujii, S.Koyasu
  • Organizer: The 14^<th>.International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] マウス腸間膜に存在するnatural helper cellの自然免疫機構における役割 (2009)
  • Author(s): 茂呂和世,山田健人,伊川友活,河本宏,藤猪英樹,小安重夫
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] マウス腸間膜に存在する natural helper cell の自然免疫機構における役割 (2009)
  • Author(s): 茂呂和世, 山田健人, 伊川友活, 河本宏, 藤猪英樹, 小安重夫
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Roles of IL-17A in Helicobacter pyroli-induced gastritis. (2008)
  • Author(s): Nagai S, Yamada T, Iwakura Y, Koyasu S
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Roles of IL-17A in Helicobacter pyroli-induced gastritis. (2008)
  • Author(s): Nagai s, Yamada T, Ivvakura Y, Koyasu S
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都・国立京都国際会館
  • Year and Date: 2008-12-01
• [Remarks] ホームページ等なし