| Project/Area Number |
20590356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NISHIGAMI Takashi Hyogo College of Medicine, 医学部, 教授 (70131589)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Tohru 兵庫医科大学, 医学部, 教授 (20227408)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 消化器 / 唾液腺 / 消化器・唾液腺 / 潰瘍性大腸炎 / クローン病 |
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| Research Abstract |
MUC1 and MUC5AC were frequently found in inflammatory mucosa in patients with long-standing ulcerative colitis (UC) and large intestinal cancer associated with UC. These mucins may serve as useful surveillance markers for large intestinal cancers associated with UC. The immunohistological phenotype of adenocarcinoma which arises in the anal fistula of Crohn's disease (CD) reflected characteristics of rectal mucosa, not of anal ductal epithelium, suggesting that adenocarcinoma in the anal fistula originates from rectal mucosa. Mutation of the MSH6 gene, methylation of the CDKN2A/p16 gene, and microsatellite instability were found in large intestinal cancers associated with UC, whereas these gene abnormalities were not detected in malignant lymphoma associated with UC. In the case of malignant lymphoma, EB virus infection was found in lymphoma cells. These results suggest that gene abnormalities may be involved in the development of large intestinal cancers associated with UC, while infection of B lymphocytes with EB virus may cause malignant lymphoma in UC patients against the background of long-standing inflammation.
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