| Project/Area Number |
20590357
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
SADAHIRA Yoshito Kawasaki Medical School, 医学部, 教授 (30178694)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WADA Hideho 川崎医科大学, 医学部, 教授 (70191830)
TSUCHIYAMA Junjiro 川崎医科大学, 医学部, 講師 (50454806)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 血液 / sphingosine-1-phosphate receptor / 細胞遊走 / マントル細胞リンパ腫 / FTY720 / Akt / protein phophatase 2A / 病理学 / 成人T細胞白血病リンパ腫 / スフィンゴシン-1-リン酸 / シグナリング / 細胞運動 / 免疫組織化学 / レセプター / 血管内皮細胞 / リアルタイムRT-PCR |
|---|
| Research Abstract |
In this study, we found that sphingosine-1-phopshate (S1PR1) was strongly expressed in mantle cell lymphoma and adult T-cell leukemia/lymphoma and S1PR1 immunohistochemistry can be used as a robust means for the diagnosis of mantle cell lymphoma in formalin-fixed and paraffin-embedded sections. We further studied the impacts of FTY 720 on mantle cell lymphoma cells and HTLV-1 infected T-cells with high S1PR1 expression. It showed possibility that FTY 720 of 10uM concentration suppresses cell proliferation and survival of these cells by activating PP2A whereas that of 1 to 10nM concentrations suppresses serum-induced cell motility via FTY720 phosphate /S1PR1 signaling.
|
