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Predictive value of estrogen receptor-beta for adjuvant therapy in breast cancer patients.

Research Project

Project/Area Number 20590359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research Institution公益財団法人がん研究会 (2010)
Japanese Foundation For Cancer Research (2008-2009)

Principal Investigator

AKIYAMA Futoshi  公益財団法人がん研究会, がん研究所病理部, 臨床病理担当部長 (50222550)

Co-Investigator(Kenkyū-buntansha) 本間 尚子  財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 (70321875)
Co-Investigator(Renkei-kenkyūsha) 堀井 理絵  公益財団法人がん研究会, がん研究所病理部, 研究員 (20446272)
石川 雄一  公益財団法人がん研究会, がん研究所病理部, 部長 (80222975)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords乳癌 / 予後 / エストロゲン・レセプターβ / エストロゲン・レセプターα / プロゲステロン・レセプター / HER2 / 術後無補助療法 / tamoxifen治療 / タモキシフェン治療 / エストロゲンレセプターβ / 術後無補助療法群 / 自然経過 / エストロゲンレセプターα / プロゲステロンレセプター
Research Abstract

We have previously shown that estrogen receptor-β(ER-β) status is a predictor of clinical outcome in breast cancer patients treated with adjuvant tamoxifen monotherapy. We studied on patients with no adjuvant therapy, and revealed that ER-βstatus was not a predictor of clinical outcome in these patients. This result suggests that difference of clinical outcome observed in patients with tamoxifen therapy reflects the effect of tamoxifen.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (17 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Estrogen receptor β2011

    • Author(s)
      Younes M, Honma N
    • Journal Title

      Arch Pathol Lab Med

      Volume: 135 Pages: 63-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years2009

    • Author(s)
      Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T, Yoshimura N, Harada N
    • Journal Title

      Breast Cancer Res

      Volume: 11(4)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular characterization of apocrine carcinoma of the breast : Validation of an apocrine protein signature in a well-defined cohort2009

    • Author(s)
      Celis JE, Cabezon T, Moreira JM, Gromov P, Gromova I, Timmermans-Wielenga V, Iwase T, Akiyama F, Honma N, Rank F
    • Journal Title

      Mol Oncol

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular characterization of apocrine carcinoma of the breast : validation of an apocrine eprotein signature in a well-defined cohort2009

    • Author(s)
      Celis JE, Akiyama F, Honma N, et al.
    • Journal Title

      Mol Oncol 3

      Pages: 220-237

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterative use multiple exons 1 of aromatase gene in cancerous and normal breast tissues from woman over the age of 80 years2009

    • Author(s)
      Honma N, Akiyama F, et al.
    • Journal Title

      Breast Cancer Res 11:R48(online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of apocrine carcinoma of the breast : validation of an apocrine eprotein signature in a well-defined cohort2009

    • Author(s)
      Celis JE, Akiyama F, Honma N, et al.
    • Journal Title

      Mol Oncol (Epub ahead of print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast2008

    • Author(s)
      Honma N, Saji S, Kurabayashi R, Aida J, Arai T, Horii R, Akiyama F, Iwase T, Harada N, Younes M, et al
    • Journal Title

      APMIS

      Volume: 116(10) Pages: 923-930

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy2008

    • Author(s)
      Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G
    • Journal Title

      J Clin Oncol

      Volume: 26(22) Pages: 3727-3734

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clinical importance of estrogen receptor-β evaluation in breast cancer patients treated with adjuvant tamoxifen therapy2008

    • Author(s)
      Honma N, Akiyama F, et al.
    • Journal Title

      J Clin Oncol 26

      Pages: 3727-3734

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oestrogen receptor-β1 but not oestrogen receptor-βcx is of prognostic value in apocrine carcinoma of the breast2008

    • Author(s)
      Honma N, Akiyama F, et al.
    • Journal Title

      APMIS 116

      Pages: 923-930

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinical importance of Ki-67 evaluation in breast cancer patients treated with adjuvant tamoxifen therapy2010

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,伊藤良則,秋山太
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 術後tamoxifen単独補助療法後乳癌症例におけるandrogen receptor発現の臨床病理学的意義についての検討2010

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,伊藤良則,秋山太
    • Organizer
      第11回ホルモンと癌研究会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 乳癌におけるandrogen receptor発現の臨床病理学的意義2010

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,新井冨生,伊藤良則,秋山太
    • Organizer
      第18回日本乳癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Clinical importance of Ki-67 evaluation in breast cancer patients treated with adjuvant tamoxifen therapy.2010

    • Author(s)
      本間尚子, 堀井理絵, 秋山太, 他
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳癌におけるbcl-2の臨床病理学的意義についての検討2009

    • Author(s)
      本間尚子,堀井理絵,倉林理恵,新井冨生,沢辺元司,田久保海誉,秋山太
    • Organizer
      第98回日本病理学会会誌
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 乳癌におけるbcl-2の臨床病理学的意義についての検討2009

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,新井冨生,松浦正明,伊藤良則,秋山太
    • Organizer
      第17回日本乳癌学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 乳癌におけるbcl-2の臨床病理学的意義についての検討2009

    • Author(s)
      本間尚子、秋山太, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳癌におけるbcl-2の臨床病理学的意義についての検討2009

    • Author(s)
      本間尚子、秋山太, 他
    • Organizer
      第17回日本乳癌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 術後tamoxifen単独補助療法後乳癌におけるestrogen receptor-beta検索の臨床的重要性2008

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,田久保海誉,松浦正明,伊藤良則,秋山太
    • Organizer
      第8回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 術後tamoxifen単独補助療法後乳癌におけるestrogen receptor-β検索の臨床的重要性2008

    • Author(s)
      本間尚子,堀井理絵,倉林理恵,新井冨生,田久保海誉,秋山太
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] 術後tamoxifen単独補助療法後乳癌におけるestrogen receptor-beta検索の臨床的重要性2008

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,田久保海誉,内海俊明,原田信広,松浦正明,伊藤良則,秋山太
    • Organizer
      第9回ホルモンと癌研究会
    • Place of Presentation
      岐阜
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical importance of estrogen receptor-βevaluation in breast cancer patients treated with adjuvant tamoxifen therapy2008

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,田久保海誉,松浦正明,伊藤良則,秋山太
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 術後tamoxifen単独補助療法後乳癌におけるestrogen receptor-β検索の臨床的重要性2008

    • Author(s)
      本間尚子,堀井理絵,岩瀬拓士,佐治重衡,倉林理恵,新井冨生,田久保海誉,松浦正明,伊藤良則,秋山太
    • Organizer
      第16回日本乳癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 術後 tamoxifen 単独補助療法後乳癌における estrogen receptor-β検索の臨床的重要性2008

    • Author(s)
      本間尚子, 秋山太, 他
    • Organizer
      第97回日本病理学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] 術後 tamoxifen 単独補助療法後乳癌における estrogen receptor-β検索の臨床的重要性2008

    • Author(s)
      本間尚子, 秋山太, 他
    • Organizer
      第9回ホルモンと癌研究会
    • Place of Presentation
      岐阜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 術後 tamoxifen 単独補助療法後乳癌における estrogen receptor-β検索の臨床的重要性2008

    • Author(s)
      本間尚子, 秋山太, 他
    • Organizer
      第16回日本乳癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 術後単独タモキシフェン治療後乳癌におけるエストロゲン・レセプター-β検索の臨床的意義2008

    • Author(s)
      本間尚子, 秋山太, 他
    • Organizer
      第67回日本癌会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Book] 第2部組織型と診断の実際I.上皮性腫瘍B.悪性2.浸潤癌b.特殊型(7)アポクリン癌.腫瘍病理鑑別診断アトラス「乳癌」2010

    • Author(s)
      本間尚子
    • Publisher
      東京:文光堂
    • Related Report
      2010 Final Research Report
  • [Book] C.乳腺疾患の概要と鑑別診断I上皮性腫瘍1.癌および境界病変(8)アポクリン癌.癌治療指針のための病理診断プラクティス「乳腺」

    • Author(s)
      本間尚子
    • Publisher
      東京:中山書店(印刷中)
    • Related Report
      2010 Final Research Report
  • [Remarks] 1.乳癌診療ガイドライン2011年版の病理診断、ホルモン受容体の項に、[雑誌論文]の4に記した論文が引用された。

    • Related Report
      2010 Final Research Report
  • [Remarks] 2.[雑誌論文]の4に記した論文の紹介記事"Estrogen receptor-beta status influences breast cancer prognosis"が、Reuters Health Informationとして、2008年8月27日付で配信された。

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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