Predictive value of estrogen receptor-beta for adjuvant therapy in breast cancer patients.
| Project/Area Number |
20590359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | 公益財団法人がん研究会 (2010)
Japanese Foundation For Cancer Research (2008-2009) |
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Principal Investigator |
AKIYAMA Futoshi 公益財団法人がん研究会, がん研究所病理部, 臨床病理担当部長 (50222550)
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| Co-Investigator(Kenkyū-buntansha) |
本間 尚子 財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 (70321875)
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| Co-Investigator(Renkei-kenkyūsha) |
堀井 理絵 公益財団法人がん研究会, がん研究所病理部, 研究員 (20446272)
石川 雄一 公益財団法人がん研究会, がん研究所病理部, 部長 (80222975)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳癌 / 予後 / エストロゲン・レセプターβ / エストロゲン・レセプターα / プロゲステロン・レセプター / HER2 / 術後無補助療法 / tamoxifen治療 / タモキシフェン治療 / エストロゲンレセプターβ / 術後無補助療法群 / 自然経過 / エストロゲンレセプターα / プロゲステロンレセプター |
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| Research Abstract |
We have previously shown that estrogen receptor-β(ER-β) status is a predictor of clinical outcome in breast cancer patients treated with adjuvant tamoxifen monotherapy. We studied on patients with no adjuvant therapy, and revealed that ER-βstatus was not a predictor of clinical outcome in these patients. This result suggests that difference of clinical outcome observed in patients with tamoxifen therapy reflects the effect of tamoxifen.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast2008
Author(s)
Honma N, Saji S, Kurabayashi R, Aida J, Arai T, Horii R, Akiyama F, Iwase T, Harada N, Younes M, et al
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Journal Title
APMIS
Volume: 116(10)
Pages: 923-930
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