| Project/Area Number |
20590360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization |
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Principal Investigator |
KITAMURA Hiroshi Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 千葉東病院臨床研究センター, 専任室長 (40287701)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Motonobu 独立行政法人国立病院機構千葉東病院, 臨床研究センター, 室長・内科部長 (60443090)
IMASAWA Toshiyuki 独立行政法人国立病院機構千葉東病院, 臨床研究センター, 室長・内科医長 (80348276)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病性腎症 / 病理 / 腎生検 / 予後 / 病理学 |
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| Research Abstract |
Diabetic nephropathy shows wide variety of pathological changes based on multiple factors such as endothelial injury and accumulation of extracellular matrix. In this study, we analyzed the cases of diabetic nephropathy diagnosed by renal biopsy to investigate the correlations between pathological changes and prognosis of renal function in addition to clinical parameters. We found some pathological parameters that had significant relationship with the prognosis of renal function and clinical parameters such as renal function, proteinuria at the time of renal biopsy and diabetic retinopathy. It is suggested that the pathological findings are very important in the management of diabetic nephropathy.
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