Signaling cross-talk between G protein-coupled receptor and tetraspanin in tumor inflammatory microenvironment

• Project/Area Number: 20590363
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: FURUYA Mitsuko Yokohama City University, 医学部, 准教授 (10361445)
• Co-Investigator(Kenkyū-buntansha): TANAKA Reiko 千葉大学, 真菌研究医学ンター, 助教 (60143319) ; 米満 吉和 千葉大学, 大学院・医学研究院, 教授 (40315065) ; 木村 定雄 千葉大学, 医学研究院, 教授 (40134225)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子病理 / 腫瘍 / 4回膜貫通蛋白質 / G蛋白質 / シグナル / クロストーク

Research Abstract

The difference of inflammatory microenvironment between ovarian cancers and endometriosis was investigated. We detected three CXCR3 variants in human tissues. Quantitative analyses revealed differential expressions of three variants. CXCR3-alt was upregulated and CXCR3B was downregulated in caners compared with endometriosis. In situ hybridization demonstrated preferential expression of CXCR3B in non-cancerous vessels and CXCR3-alt was detectable mainly in tumor vessels. Collective data suggest that differential expression patterns of CXC chemokines and CXCR3 variants are involved in inflammatory microenvironments of ovarian cancers and cancer-associated conditions.

Research Products

• [Journal Article] Complexity of Tumor Vasculature and Molecular Targeting Therapies. (2011)
  • Author(s): Furuya M, Aoki I, et al.
  • Journal Title: Front Biosci 3 Pages: 549-561
  • Peer Reviewed
• [Journal Article] Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia. (2011)
  • Author(s): Furuya M, Nagahama K, Aoki I, et al.
  • Journal Title: Journal of Pregnancy ID 123717
  • Peer Reviewed
• [Journal Article] Aberrant CD20 expression in angioimmunoblastic T-cell lymphoma. (2011)
  • Author(s): Tachibana T, Tomita N, Furuya M, et al.
  • Journal Title: Int Med 50(5) Pages: 495-499
  • NAID: 130000649867
  • Peer Reviewed
• [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, Furuya M, Nagahama K, et al.
  • Journal Title: Nephrol Dial Transplant. 25 Pages: 3884-3890
  • Peer Reviewed
• [Journal Article] Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors. (2010)
  • Author(s): Shida T, Furuya M, Miyazaki M, et al.
  • Journal Title: Cancer Chemother Pharmacol. 65 Pages: 889-893
  • Peer Reviewed
• [Journal Article] Nakatani Y BHD syndrome. (2010)
  • Author(s): Koga S, Furuya M
  • Journal Title: Nippon Rinsho. 68 Pages: 361-369
• [Journal Article] Complexity of Tumor Vasculature and Molecular Targeting Therapies. (2010)
  • Author(s): Furuya M, Nagahama K, et al.
  • Journal Title: Frontier Bioscience Volume: (In press)
  • Peer Reviewed
• [Journal Article] Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia (2010)
  • Author(s): Furuya M, Kurasawa K, et al.
  • Journal Title: Journal of Pregnancy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Aberrant CD20 expression in angioimmunoblastic T-cell lymphoma. (2010)
  • Author(s): Tachibana T, Tomita N, Furuya M, et al.
  • Journal Title: Internal Medicine Volume: 50 Pages: 495-499
  • NAID: 130000649867
  • Peer Reviewed
• [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, Furuya M, Nagahama K, et al.
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 3884-3890
  • Peer Reviewed
• [Journal Article] Expression of an activated mammalian target of rapamycin (mTOR) in gastroente ropancreatic neuroendocrine tumors. (2010)
  • Author(s): Shida T, Furuya M, Miyazaki M, et al.
  • Journal Title: Cancer Chemother Pharmacol Volume: 65 Pages: 889-893
  • Peer Reviewed
• [Journal Article] 腹腔内再発を繰り返した子宮間葉系腫瘍:Perivascular Epithelioid Cell Tumor (PEComa)の一例 (2010)
  • Author(s): 新野史, 窪田興志, 稲山嘉明, 古屋充子
  • Journal Title: 日本婦人科病理学会誌 Volume: 1 Pages: 31-33
• [Journal Article] Lung Cysts in BHD Syndrome : Histopathological characteristics and Aberrant Sequence Repeats. (2009)
  • Author(s): Koga S, Furuya M, Nakatani Y, et al.
  • Journal Title: Pathol Int 59 Pages: 720-728
  • Peer Reviewed
• [Journal Article] Metastasis of malignant struma ovarii to the lumbar spine. (2009)
  • Author(s): Yamashita M, Furuya M, Takahashi K, et al.
  • Journal Title: J Clin Neurosci. 17 Pages: 269-272
  • Peer Reviewed
• [Journal Article] Complexity of Tumor Vasculature and Microenvironment. (2009)
  • Author(s): Furuya M, Yonemitsu Y, Aoki I.
  • Journal Title: Curr Pharm Des 15 Pages: 1854-1867
  • Peer Reviewed
• [Journal Article] Lung cysts in Birt-Hogg-Dube syndrome : histopathological characteristics and aberrant sequence repeats (2009)
  • Author(s): Koga S, et al
  • Journal Title: Pathol Int 59(10) Pages: 720-728
  • Peer Reviewed
• [Journal Article] Complexity of tumor vasculature and microenvironment (2009)
  • Author(s): Furuya M, et al
  • Journal Title: Current Pharmaceutical Design 15(16) Pages: 1854-1867
  • Peer Reviewed
• [Journal Article] Metastasis of malignant struma ovarii to the lumbar spine (2009)
  • Author(s): Yamashita M, et al
  • Journal Title: J Clin Neurosci. 17(2) Pages: 269-272
  • Peer Reviewed
• [Journal Article] Expression of an activated mammalian target of rapamycin(mTOR)in gastroenteropancreatic neuroendocrine tumors (2009)
  • Author(s): Shida T, et al
  • Journal Title: Cancer Chemother Pharmacol. 65(5) Pages: 889-893
  • Peer Reviewed
• [Journal Article] Pathophysiology of Placentation Abnormalities in Pregnancy-Induced Hypertension. (2008)
  • Author(s): Furuya M, Ishida J, Fukamizu A, et al.
  • Journal Title: Vasc Health Risk Manag 4 Pages: 1301-1313
  • Peer Reviewed
• [Journal Article] Cancer Neovascularization and Proinflammatory Microenvironments. (2008)
  • Author(s): Furuya M, Yonemitsu Y.
  • Journal Title: Curr Cancer Drug Targets 8 Pages: 253-265
  • Peer Reviewed
• [Journal Article] The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors. (2008)
  • Author(s): Shida T, Furuya M, Miyazaki M, et al.
  • Journal Title: Mod Pathol. 21 Pages: 1363-1370
  • Peer Reviewed
• [Journal Article] Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension. (2008)
  • Author(s): Furuya M, Ishida J, Fukamizu A, et al.
  • Journal Title: Lab Invest 88 Pages: 416-429
  • Peer Reviewed
• [Journal Article] Cancer neovascularization and proinflammatory microenvironments. (2008)
  • Author(s): Furuya M, Yonemitsu Y.
  • Journal Title: Curr Cancer Drug Targets. 8(4) Pages: 253-265
  • Peer Reviewed
• [Journal Article] Pathophysiology of placentation abnormalities in pregnancy-induced hypertension. (2008)
  • Author(s): Furuya M, Fukamizu A, et al.
  • Journal Title: Vasc Health Risk Manag. 4(6) Pages: 1301-1313
  • Peer Reviewed
• [Journal Article] Impaired placental neovascularization in mice with pregnancy-associated hypertension. (2008)
  • Author(s): Furuya M, Fukamizu A, et al.
  • Journal Title: Lab Invest. 88(4) Pages: 416-429
  • Peer Reviewed
• [Journal Article] The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors. (2008)
  • Author(s): Shida T, Furuya M, et al.
  • Journal Title: Mod Pathol. 21(11) Pages: 1363-1370
  • Peer Reviewed
• [Journal Article] Differential Expression Patterns of CXCR3 Variants and Corresponding CXC Chemokines in Clear Cell Ovarian Cancers and Endometriosis.
  • Author(s): Furuya M, Tanaka R, Aoki I, et al.
  • Journal Title: Gynecol Oncol in press
  • Peer Reviewed
• [Presentation] Distinct expression patterns of CXCR3 variants in tumor and tumor-associated inflammatory diseases of the ovary. (2010)
  • Author(s): 古屋充子, 宮城悦子, ほか
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] 腹腔内再発を繰り返した子宮間葉系腫瘍の一例 (2010)
  • Author(s): 新野史, 古屋充子, ほか
  • Organizer: 第32回日本産婦人科病理学会
  • Place of Presentation: 昭和大学(東京)
  • Year and Date: 2010-06-03
• [Presentation] 卵巣腫瘍におけるINF-γ誘導性ケモカイン受容体CXCR3バリアントの解析 (2010)
  • Author(s): 古屋充子, 米山朋那, ほか
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-28
• [Presentation] Birt-Hogg-Dube症候群と判明した多発性肺嚢胞の病理学的特徴 (2010)
  • Author(s): 古屋充子, 中谷行雄, ほか
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] 卵巣腫瘍におけるINF-γ誘導性ケモカイン受容体CXCR3バリアントの解析 (2010)
  • Author(s): 古屋充子, 田中玲子, 青木一郎, ほか
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 東京
• [Presentation] BHD症候群と判明した多発性肺嚢胞の病理学的特徴 (2010)
  • Author(s): 古屋充子, 古賀俊輔, 中谷行雄, ほか
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 東京
• [Presentation] Distinct expression patterns of CXCR3 variants in tumor and tumor-associated inflammatory diseases of the ovary. (2010)
  • Author(s): 古屋充子, 宮城悦子, 青木一郎, ほか
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 腹腔内再発を繰り返した子宮間葉系腫瘍の一例 (2010)
  • Author(s): 新野史, 稲山嘉明, 古屋充子
  • Organizer: 第32回日本婦人科病理学会
  • Place of Presentation: 東京
• [Presentation] 経過中にCD20陽性を示したAITLの一例 (2010)
  • Author(s): 立花崇孝, 富田直人, 古屋充子, ほか
  • Organizer: 第50回日本リンパ網内系学会
  • Place of Presentation: 新潟
• [Presentation] 妊娠高血圧症候群における胎児・胎盤機能評価マーカーの検討 (2010)
  • Author(s): 古屋充子
  • Organizer: 神奈川県産婦人科医会地方部会
  • Place of Presentation: 平塚
• [Presentation] 妊娠高血圧症候群における胎盤解析の展望 (2009)
  • Author(s): 古屋充子
  • Organizer: 平成21年神奈川県産婦人科医会地方部会(秋期)
  • Place of Presentation: 小田急ホテル相模大野
  • Year and Date: 2009-11-15
• [Presentation] 卵管癌と子宮頸部腺癌の共存により細胞診断に苦慮した1例 (2009)
  • Author(s): 杉浦賢, 他
  • Organizer: 第48回日本臨床細胞学会秋期大会
  • Place of Presentation: JALリゾートシーホークホテル福岡
  • Year and Date: 2009-10-31
• [Presentation] 子宮頚部絨毛腺管状乳頭腺癌 villoglandular papillary adenocarcinoma の一例 (2009)
  • Author(s): 井畑穣, 他
  • Organizer: 第48回日本臨床細胞学会秋期大会
  • Place of Presentation: JALリゾートシーホークホテル福岡
  • Year and Date: 2009-10-30
• [Presentation] Pathophysiology of the lung cysts caused by BHD mutation in Birt-Hogg-Dube syndrome patients (2009)
  • Author(s): 古賀俊輔, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] 娠高血圧症モデルマウスにおける胎盤の血管構造変化に関する研究 (2009)
  • Author(s): 石田純治, 他
  • Organizer: 第30回日本妊娠高血圧学会総会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2009-08-29
• [Presentation] 妊娠高血圧症候群胎盤における血管新生の病態解析 (2009)
  • Author(s): 古屋充子, 他
  • Organizer: 第30回日本妊娠高血圧学会総会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2009-08-29
• [Presentation] 妊娠高血圧症候群胎盤における血管新生の病態解析 (2009)
  • Author(s): 古屋充子, 他
  • Organizer: 平成21年神奈川県産婦人科医会地方部会
  • Place of Presentation: 横浜市教育文化ホール
  • Year and Date: 2009-07-04
• [Presentation] WT1遺伝子のexon10のナンセンス変異を認め腎移植に至った1例 (2009)
  • Author(s): 村上あゆみ, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] 卵巣腫瘍における血管作動性ケモカイン受容体CXCR3とそのリガンドの発現解析 (2009)
  • Author(s): 米山朋那, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察 (2009)
  • Author(s): 古賀俊輔, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] 卵巣腫瘍における血管作動性ケモカイン受容体CXCR3とそのリガンドの発現解析 (2009)
  • Author(s): 米山朋那, 古屋充子, 青木一郎, ほか
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察 (2009)
  • Author(s): 古賀俊輔, 古屋充子, 中谷行雄, ほか
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Expression of CXCR3 variant in ovarian neoplasms. (2009)
  • Author(s): 古屋充子, 宮城悦子, 青木一郎, ほか
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Pathophysiology of the lung cysts caused by BHD mutation in BHD syndrome patients. (2009)
  • Author(s): 古賀俊輔, 古屋充子, 中谷行雄, ほか
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 妊娠高血圧症候群における胎盤血管新生の病態解析 (2009)
  • Author(s): 古屋充子, 石田純治, 深水昭吉, ほか
  • Organizer: 神奈川県産婦人科医会地方部会
  • Place of Presentation: 横浜
• [Presentation] 妊娠高血圧症候群における胎盤血管新生の病態解析 (2009)
  • Author(s): 古屋充子, 石田純治, 深水昭吉, ほか
  • Organizer: 第30回日本妊娠高血圧学会総会
  • Place of Presentation: 岡山
• [Presentation] 妊娠高血圧症モデルマウスにおける胎盤の血管構造変化に関する研究 (2009)
  • Author(s): 石田純治, 古屋充子, 深水昭吉, ほか
  • Organizer: 第30回日本妊娠高血圧学会総会
  • Place of Presentation: 岡山
• [Presentation] 妊娠高血圧症候群における胎盤解析の展望 (2009)
  • Author(s): 古屋充子
  • Organizer: 神奈川県産婦人科医会地方部会
  • Place of Presentation: 相模大野
• [Presentation] 当院における絨毛性疾患10年の検討 (2009)
  • Author(s): 井畑穰, 宮城悦子, 古屋充子, ほか
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜
• [Presentation] The expression of Neuro D and mash in the gastroenteropancreatic neuroendocrine tumors (2008)
  • Author(s): Shida T, Furuya M, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Implication of CXC-chemokines and their receptors for proinflammatory microenvironments of ovarian neoplasms (2008)
  • Author(s): Furuya M, et al
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] A Case of Multiple Pulmonary Cysts Associated with Birt-Hogg-Dube Gene Mutation. (2008)
  • Author(s): Koga S, Furuya M, et al.
  • Organizer: INAUGURAL BHD SYMPOSIUM
  • Place of Presentation: Roskilde Denmark
  • Year and Date: 2008-09-03
• [Presentation] Birt-Hogg-Dube syndromeが疑われる肺嚢胞性疾患の分子病理学的検討 (2008)
  • Author(s): 古賀俊輔, 古屋充子, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-17
• [Presentation] 妊娠高血圧症候群における血管新生の病態解析 (2008)
  • Author(s): 古屋充子, 石田純治, 武内利直, 碓井宏和, 中谷行雄, 深水昭吉
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] BHD syndromeが疑われる肺嚢胞性疾患の分子病理学的検討 (2008)
  • Author(s): 古賀俊輔, 古屋充子, 中谷行雄, ほか
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] A Case of Multiple Pulmonary Cysts Associated with BHD Gene Mutation. (2008)
  • Author(s): 古賀俊輔, 古屋充子, 中谷行雄, et al
  • Organizer: 1st INAUGURAL BHD SYMPOSIUM
  • Place of Presentation: Roskilde
• [Presentation] Implication of CXC-chemokines and their receptors for proinflammatory microenvironments of ovarian neoplasms. (2008)
  • Author(s): 古屋充子, 宮城悦子, 青木一郎, ほか
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] The expression of Neuro D and mash in the gastroenteropancreatic NEC. (2008)
  • Author(s): 志田崇, 古屋充子, 宮崎勝, ほか
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Book] Stem cell and cancer stem cell (2010)
  • Author(s): Furuya M
  • Publisher: Springer(In press)
• [Book] STEM CELLS AND CANCER STEM CELLS(Complexity of Tumor Angiogenesis.)(M.A. Hayat, ed.)
  • Author(s): Furuya M
  • Publisher: Springer, in press
• [Remarks] ホームページ等
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