• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell lines

Research Project

Project/Area Number 20590365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionShimane University

Principal Investigator

KAKAZU Naoki  島根大学, 医学部, 准教授 (20264757)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords横紋筋肉腫 / 染色体転座 / 病型特異的転座 / キメラ遺伝子
Research Abstract

Rhabdomyosarcoma(RMS) is characterized by the specific chromosomal translocations involving 2q35 and 1p36 bands, which generate the PAX3-and PAX7-related chimera genes, respectively. We analyzed RMS cell lines by spectral karyotyping(SKY) and detected many chromosomal translocations, in which the PAX3 and PAX7 genes were not involved. We analyzed their breakpoint regions by FISH but could not identify novel chimera genes, which suggests that the translocations were secondarily caused by chromosomal instability due to the RMS development.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2010

    • Author(s)
      Uemura M, Niwa Y, Kakazu N, Adachi N, Kinoshita K.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of p53 pathway by Nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells2009

    • Author(s)
      Miyachi M, Kakazu N, Yagyu S, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tsuchiya K, Iehara T, Hosoi H.
    • Journal Title

      Clin Cancer Res

      Volume: 15 Pages: 4077-4084

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells.2009

    • Author(s)
      Miyachi M, Kakazu N, et al.
    • Journal Title

      Clin Cancer Res 15

      Pages: 4077-4084

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chromosomal constitution of postmitotic neurons, assessed by neuronal nuclear transfer into oocytes and in ES cell lines derived from them.2009

    • Author(s)
      Osada T, Kakazu N, et al.
    • Journal Title

      Cytogenet Genome Res 125

      Pages: 201-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel PAX3 rearrangement in embryonal rhabdomyosarcoma2009

    • Author(s)
      Hosoi H, Kakazu N, et al.
    • Journal Title

      Cancer Genet Cytogenet 189

      Pages: 98-104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi