Comparative analysis of micro RNA expressions on between reactive lymphoid follicles and follicular lymphomas focusing to post-translational process.
Project/Area Number |
20590366
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Okayama University |
Principal Investigator |
KONDO Eisaku Okayama University, 腫瘍病理学部, 部長 (30252951)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 分子病理 / 濾胞性リンパ腫 / microRNA / 胚中心 / トランスジェニックマウス / B細胞性リンパ腫 / リンパ腫 / マイクロダイセクション |
Research Abstract |
We planned the expression analysis of micro RNAs on between human follicular lymphomas (FLs) and their non-neoplastic counterpart, germinal centers (GCs) to elucidate the lymphomagenesis of FLs. From the results of miRNA profiling of human FLs in comparison with that of GCs, also of quantitative analysis by real-time PCR for sorted GC cells and FL cells, miR-146a and miR-193b revealed to be up-regulated in FLs than GCs, whereas miR-26a seemed to be down-regulated. Based on these results, we further generated transgenic mice overexpressing mouse miR-146a under regulation by immunoglobulin enhancer/promotor, and explore the phenotypic features of their B cells. Consequently, splenic GCs in miR-146a Tg mice seemed to be enlarged in response to stimulation by an exogenous antigen than those in wild type mice. The details are still under investigation now.
|
Report
(4 results)
Research Products
(74 results)
-
-
-
-
-
[Journal Article] Intramuscular transplantation of engineered hepatictissueconstructs corrects acute and chronic liver failure in mice.2010
Author(s)
Navarro-Alvarez N, Soto-Gutierrez A, Chen Y, Caballero-Corbalan J, Hassan W, Kobayashi S, Takei J, Kondo Y, Iwamuro M, Yamamoto K, Kondo E, Tanaka N,FoxIJ, Kobayashi N
-
Journal Title
Journal of Hepatology 52
Pages: 211-219
Related Report
-
-
[Journal Article] Isolation andpropagation of a human CD133-negative colon tumor-derived cell line withtumorigenic and angiogenic properties.2010
Author(s)
*Navarro-Alvarez N, *Kondo E, *Soto-gutierrez A, Kawamoto H, Hassan W, YuasaT, Kubota Y, Seita M, Nakahara H, Hayashi T, Nishikawa Y, Hassan RARA,JavedSM, Noguchi H, Matsumoto S, Nakaji S, Tanaka N, Kobayashi N
-
Journal Title
Cell Transplantation 19
Pages: 865-877
Related Report
-
[Journal Article] Characteristics of CD133(+) human colon cancer SW620 cells.2010
Author(s)
Kawamoto H, Yuasa T, Kubota Y, Seita M, Sasamoto H, Javed SM, Hayashi T,Nakahara H, Hassan R, Iwamuro M, Kondo E, Nakaji S, Tanaka N, Kobayashi N
-
Journal Title
CellTransplantation 19
Pages: 857-864
Related Report
-
-
[Journal Article] Comparative analysis of endoderm formation efficiency between mouse EScellsand iPS cells.2010
Author(s)
Iwamuro M, Komaki T, Kubota Y, Seita M, Kawamoto H, Yuasa T, Javed SM,Hassan RARA, Nakaji S, Nishikawa Y, Kondo E, Yamamoto K, Kobayashi N
-
Journal Title
Cell Transplantation 19
Pages: 831-839
Related Report
-
[Journal Article] Hepatic differentiation of mouse iPS cells in vitro.2010
Author(s)
Iwamuro M, Komaki T, Kubota Y, Seita M, Kawamoto H, Yuasa T, Javed SM,Hassan RARA, Nakaji S, Nishikawa Y, Kondo E, Yamamoto K, Fox IJ, KobayashiN
-
Journal Title
CellTransplantation 19
Pages: 841-847
Related Report
-
-
[Journal Article] Treatment of acute liver failure in mice by hepatocyte xenotransplantation.2010
Author(s)
Yamamoto T, Navarro-Alvarez N, Soto-Gutierrez A, Yuasa T, Iwamuro M, Kubota Y, Seita M, Kawamoto H, Javed SM, Kondo E, Noguchi H, Kobayashi S, Nakaji S, Kobayashi N.
-
Journal Title
Cell Transplant 19
Pages: 799-806
Related Report
-
-
-
-
-
-
-
-
[Journal Article] Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice.2009
Author(s)
Nakahara H, Misawa H, Hayashi T, Kondo E, Yuasa T, Kubota Y, Seita M, Kawamoto H, Hassan WA, Hassan RA, Javed SM, Tanaka M, Endo H, Noguchi H, Matsumoto S, Takata K, Tashiro Y, Nakaji S, Ozaki T, Kobayashi N.
-
Journal Title
Transplantation. 88(3)
Pages: 346-353
Related Report
-
[Journal Article] Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations.2009
Author(s)
Takata K, Sato Y, Nakamura N, Kikuti YY, Ichimura K, Tanaka T, Morito T, Tamura M, Oka T, Kondo E, Okada H, Tari A, Yoshino T.
-
Journal Title
Mod Pathol 22
Pages: 940-949
Related Report
-
[Journal Article] Frequent downregulation or loss of CD79a expression in plasma cell myelomas : potential clue for diagnosis.2009
Author(s)
Tanaka T, Ichimura K, Sato Y, Takata K, Morito T, Tamura M, Kondo E, Ohara N, Yanai H, Sakai M, Takahashi S, Yoshino T.
-
Journal Title
Pathol Int 59
Pages: 804-808
NAID
Related Report
-
-
-
-
[Journal Article] Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas.2008
Author(s)
Sato, Y., Ichimura, K., Tanaka, T., Takata, K., Morito, T., Sato, H., Sato, Y., Kondo, E., Yanai, H., Ohara, N., Oka,. T, Yoshino, T.
-
Journal Title
J.Clin.Pathol. 61
Pages: 377-381
Related Report
-
[Journal Article] Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling.2008
Author(s)
Akimzhanov, A., Krenacs, L., Schlegel, T., Klein-Hessling, S., Bagdi, E., Stelkovics, E., Kondo, E., Chuvpilo, S., Wilke, P., Avots ,A., Gattenlohner, S., Muller-Hermelink, H-K., Palmetshofer, A., Serfling, E.
-
Journal Title
Am.J.Pathol. 172
Pages: 215-224
Related Report
-
[Journal Article] Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell lines.2008
Author(s)
Kondo, E., Tanaka, T., Miyake, T., Ichikawa, T., Hirai, M., Adachi, M., Yoshikawa, K., Ichimura, K., Ohara, N., Moriwaki, A., Date, I., Ueda, R., Yoshino, T.
-
Journal Title
Mol.Cancer Ther. 7
Pages: 1461-1471
Related Report
-
[Journal Article] Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.2008
Author(s)
Ohashi, K., Rai, K., Fujiwara, Y., Osawa, M., Hirano, S., Takata, K., Kondo, E., Yoshino, T, Takata, M., Tanimoto, M.
-
Journal Title
Cancer Sci. 99(9)
Pages: 1747-53
NAID
Related Report
-
[Journal Article] Ocular adnexal IgG4-related disease has uniform clinicopathology.2008
Author(s)
Sato, Y., Ohshima, K., Ichimura, K., Sato, M., Yamadori, I., Tanaka, T., Takata, K., Morito,Y, Kondo, E., Yoshino, T.
-
Journal Title
Pathol.Int. 58
Pages: 465-470
NAID
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-