Impact of the aPKC/PAR system on carcinogenesis and progression.

• Project/Area Number: 20590368
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: NAGASHIMA Yoji Yokohama City University, 医学研究科, 准教授 (10217995)
• Co-Investigator(Kenkyū-buntansha): AKIMOTO Kazunori 横浜市立大学, 医学部, 助教 (70285104)
• Co-Investigator(Renkei-kenkyūsha): CHISHIMA Takashi 横浜市立大学, 附属病院, 准教授 (70438141) ; ISHIKAWA Takashi 立大学, 市民総合医療ンター, 准教授 (80275049) ; UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439) ; ISHIGURO Hitoshi 横浜市立大学, 医学研究科, 客員准教授 (00381666) ; KANNO Hiroshi 横浜市立大学, 医学部, 准教授 (40244496) ; AOKI Ichiro 横浜市立大学, 医学研究科, 教授 (00184028) ; INAYAMA Yoshiaki 横浜市立大学, 附属病院, 教授 (10184730) ; NOZAWA Akinori 横浜市立大学, 市民総合医療センター, 准教授 (00228321)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 細胞極性 / aPKC-PAR系 / 乳癌 / 前立腺癌

Research Abstract

aPKCλ/ιhas a pivotal role in establishment and maintenance of cell polarity. In this study, we demonstrated that (1) aPKCλ/ιis overexpressed in various cancer cells, including breast and prostate cancers, (2) aPKCλ/ιinduces IL6 expression to obtain castration resistance in prostatic cancer (aPKC-IL6 pathway), and (3) correlation of expression of aPKCλ/ι and IL6 was demonstrated in the breast cancer as well as prostatic cancer.

Research Products

• [Journal Article] The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy. (2010)
  • Author(s): Kawachi K, Sasaki T, Murakami A, Ishikawa T, Kito A, Ota I, Shimizu D, Nozawa A, Nagashima Y, Machinami R, Aoki I
  • Journal Title: Pathol Res Pract 206(3) Pages: 156-162
• [Journal Article] Expression of angiotensin II type 1 receptor interacting molecule in normal human kidney and IgA nephropathy. (2010)
  • Author(s): Masuda S-I, Tamura K, Wakui H, Maeda A, Dejima T, Hirose T, Toyoda M, Azuma K, Ohsawa M, Kanaoka T, Yanagi M, Yoshida S-i, Mitsuhashi H, Matsuda M, Ishigami T, Toya Y, Suzuki D, Nagashima Y, Umemura S
  • Journal Title: Am J Physiol Renal Physiol 299(4)
• [Journal Article] Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome. (2010)
  • Author(s): Miyake N, Kosho T, Mizumoto S, Furuichi T, Hatamochi A, Nagashima Y, Arai E, Takahashi K, Kawamura R, Wakui K, Takahashi J, Kato H, Yasui H, Ishida T, Ohashi H, Nishimura G, Shiina M, Saitsu H, Tsurusaki Y, Doi H, Fukushima Y, Ikegawa S, Yamada S, Sugahara K, Matsumoto N
  • Journal Title: Hum Mutat 31(8) Pages: 966-974
• [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, Oshiro H, Kanzaki S, Yamaguchi A, Yamanaka S, Furuya M, Miura S, Kanno H, Nagashima Y, Aoki I, Nagahama K
  • Journal Title: Nephrol Dial Transplant 25(12) Pages: 3884-3890
• [Journal Article] High expression of the atypical protein kinase C λ/ι in gastric cancer is promising prognostic factor for recurrence. (2010)
  • Author(s): Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Endo I, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Nagashima Y, Ohno S
  • Journal Title: Ann Surg Oncol 17(1) Pages: 81-88
• [Journal Article] Expression of laminin γ2 chain monomer enhances invasive growth of human carcinoma cells in vivo. (2010)
  • Author(s): Tsubota Y, Ogawa T, Oyanagi J, Nagashima Y, Miyazaki K
  • Journal Title: Int J Cancer 127(9) Pages: 2031-2041
• [Journal Article] Expression of laminin γ2 chain monomer enhances invasive growth of human carcinoma cells in vivo. (2010)
  • Author(s): Tsubota Y, et.al
  • Journal Title: Int J Cancer Volume: 127(9) Pages: 2031-2041
  • Peer Reviewed
• [Journal Article] Proliferation of human lung cancer in an orthotopic transplantation mouse model. (2010)
  • Author(s): Kang Y, et.al
  • Journal Title: Exp Ther Med Volume: 1(3) Pages: 471-475
  • Peer Reviewed
• [Journal Article] Label-free biomedical imaging of hydrodynamics in single human cells. (2010)
  • Author(s): Fukunaga H, et.al
  • Journal Title: Biomedical Res Volume: 31(3) Pages: 177-181
  • Peer Reviewed
• [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting. (2010)
  • Author(s): Murakami A, et.al
  • Journal Title: Nephrol Dial Transplant Volume: 25(12) Pages: 3884-3890
  • Peer Reviewed
• [Journal Article] Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome. (2010)
  • Author(s): Miyake N, et.al
  • Journal Title: Hum Mutat Volume: 31(8) Pages: 966-974
  • Peer Reviewed
• [Journal Article] Thymic alterations in GM2 gangliosidoses model mouse. (2010)
  • Author(s): Kanzaki S, et.al
  • Journal Title: PLoS One Volume: 5(8)
  • Peer Reviewed
• [Journal Article] Expression of angiotensin II type 1 receptor interacting molecule in normal human kidney and IgA nephropathy. (2010)
  • Author(s): Masuda S-I, et.al
  • Journal Title: Am J Physiol Renal Physiol Volume: 299(4)
  • Peer Reviewed
• [Journal Article] Expression of aquaporin 1 in primary renal tumors : A prognostic indicator for clear-cell renal cell carcinoma. (2009)
  • Author(s): Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kubota Y, Nagashima Y, Yao M
  • Journal Title: Eur Urol 6(4) Pages: 690-698
• [Journal Article] aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. (2009)
  • Author(s): Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H
  • Journal Title: Pro Natl Acad Sci USA 106(38) Pages: 16369-16374
• [Journal Article] Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells. (2009)
  • Author(s): Sato H, Iwata H, Takano Y, Yamada R, Okuzawa H, Nagashima Y, Yamaura K, Ueno K, Yano T
  • Journal Title: J Pharmacol Sci 110(4) Pages: 466-475
  • NAID: 10025738277
• [Journal Article] Epithelioid angiomyolipoma of the kidney (2009)
  • Author(s): Kato I, et.al
  • Journal Title: Pathol Int 59(1) Pages: 38-43
  • Peer Reviewed
• [Journal Article] Sebaceous carcinoma of the breast (2009)
  • Author(s): Murakami A, et.al
  • Journal Title: Pathol Int 59(3) Pages: 188-192
  • Peer Reviewed
• [Journal Article] Ethmoidal lipid-rich carcinoma with focal glandular structures (2009)
  • Author(s): Oshiro H, et.al
  • Journal Title: Archives of Otolaryngology-Head & Neck Surgery 135(5) Pages: 511-514
  • Peer Reviewed
• [Journal Article] Gene expression during liver regeneration after partial hepatectomy in mice lacking type 1 tumor necrosis factor receptor (2009)
  • Author(s): Shimizu T, et.al
  • Journal Title: J Surg Res 152(2) Pages: 178-188
  • Peer Reviewed
• [Journal Article] Expression of aquaporin 1 in primary renal tumors : A prognostic indicator for clear-cell renal cell carcinoma (2009)
  • Author(s): Huang Y, et.al
  • Journal Title: Eur Urol 6(4) Pages: 690-698
  • Peer Reviewed
• [Journal Article] Prostaglandin E1(PGE1)prevents liver failure after excessive hepatectomy in rat by upregulating Cyclin C, Cyclin D1 and Bclxl (2009)
  • Author(s): Ishibe A, et.al
  • Journal Title: Wound Repair Regeneration 17(1) Pages: 62-70
  • Peer Reviewed
• [Journal Article] Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand-1 (2009)
  • Author(s): Ohba K, et.al
  • Journal Title: J Immunol 183(1) Pages: 524-532
  • Peer Reviewed
• [Journal Article] Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease (2009)
  • Author(s): Nozaki Y, et.al
  • Journal Title: J Hepatol 51(3) Pages: 548-556
  • Peer Reviewed
• [Journal Article] aPKCλ/τ promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6 (2009)
  • Author(s): Ishiguro H, et.al
  • Journal Title: Pro Natl Acad Sci USA 106(38) Pages: 16369-16374
  • Peer Reviewed
• [Journal Article] Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells (2009)
  • Author(s): Sato H, et.al
  • Journal Title: J Pharmacol Sci 110(4) Pages: 466-475
  • Peer Reviewed
• [Journal Article] A case report with speculation of the pathogenesis (2009)
  • Author(s): Kawahara T, et.al
  • Journal Title: Int J Urol 16(11) Pages: 920-921
  • Peer Reviewed
• [Journal Article] Primary synovial sarcoma of the kidney (2009)
  • Author(s): Kawahara T, et.al
  • Journal Title: Case Rep Oncol 2(3) Pages: 189-193
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 長嶋洋治, et.al
  • Journal Title: Pathology and molecular biology of renal neoplasms. : recent advances and impacts on pathological classification. Molecular mechanism and Morphology in Cancer(Nakamura M(eds.))(Bentham Science Publishers E-Book) Pages: 12-38
• [Journal Article] (2009)
  • Author(s): 長嶋洋治
  • Journal Title: 【各論】5章 泌尿器系, NEWエッセンシャル病理学(第6版)(医歯薬出版) Pages: 390-406
• [Journal Article] (2009)
  • Author(s): 長嶋洋治(分担訳)
  • Journal Title: 腎臓10-58～62(p250-251), 64～67(p252-253), 69～82(p253-257), 84～89(p258-260), 94～96(p261-262), 98～107(p262-265),「ロビンス病理学アトラス」(鷹橋浩幸, 白石泰三, 福田国彦, 羽野寛(監訳))(エルゼビア・ジャパン社) Pages: 250-265
• [Journal Article] (2009)
  • Author(s): 長嶋洋治(分担)
  • Journal Title: 解明 病理学 病気のメカニズムを解く(医歯薬出版) Pages: 214-235
• [Journal Article] (2009)
  • Author(s): 陣崎雅弘, 三上修治, 長嶋洋治
  • Journal Title: Imaging of RCC, 1. CT, 4)画像診断から組織診断へ Year book of RCC 2009(メディカルレビュー社) Pages: 55-71
• [Journal Article] Collecting duct carcinoma of the kidney : an immunohistochemical evaluation of the use of antibodies for differential diagnosis. (2008)
  • Author(s): Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Kobayashi N, Matsuzaki O, Shirai S, Aoki I, Yao M, Shima H
  • Journal Title: Hum Pathol 39(9) Pages: 1350-1359
• [Journal Article] Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan. (2008)
  • Author(s): Sakuma Y, Matsukuma S, Yoshihara M, Sakurai S, Nishii M, Kishida T, Kubota Y, Nagashima Y, Inayama Y, Sasaki T, Nakamura Y, Miura T, Kameda Y, Tsuchiya E, Miyagi Y
  • Journal Title: Cancer Lett 259(2) Pages: 119-126
• [Journal Article] 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. (2008)
  • Author(s): Hagiwara H, Sato H, Ohde Y, Takano Y, Seki T, Ariga T, Hokaiwado N, Asamoto M, Shirai T, Nagashima Y, Yano T
  • Journal Title: Br J Pharmacol 153(7) Pages: 1373-1381
• [Journal Article] Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration. (2008)
  • Author(s): Kumamoto T, Togo S, Ishibe A, Morioka D, Watanabe K, Takahashi T, Shimizu T, Matsuo KI, Kubota T, Tanaka K, Nagashima Y, Kawai J, Hayashizaki Y, Shimada H
  • Journal Title: Liver Int 28(6) Pages: 865-877
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. (2008)
  • Author(s): Fujita K, Nozaki Y, Wada K, Yoneda M, Endo H, Takahashi H, Iwasaki T, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nagashima Y, Nakajima A
  • Journal Title: Gut 57(11) Pages: 1583-1591
• [Journal Article] Antitumour effect of electrochemotherapy with bleomycin on human prostatic cancer xenograft. (2008)
  • Author(s): Ueki T, Uemura H, Nagashima Y, Ohta S, Ishiguro H, Kubota Y
  • Journal Title: Brit J Urol BJU Int 102(10) Pages: 1467-1471
• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : implications for human disease. (2008)
  • Author(s): Kirino M, Kirino Y, Takeno M, Nagashima Y, Takahashi K, Kobayashi M, Murakami S, Hirasawa T, Ueda A, Aihara M, Ikezawa Z, Ishigatsubo Y
  • Journal Title: J Allergy Clin Immunol 122(2) Pages: 290-297
• [Journal Article] Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model.(大学院優秀論文) (2008)
  • Author(s): Yamaguchi J, Nakamura F, Aihara M, Yamashita N, Usui H, Hida T, Takei K, Nagashima Y, Ikezawa Z, Goshima Y
  • Journal Title: J Invest Dermatol 128(12) Pages: 2842-2849
• [Journal Article] Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. (2008)
  • Author(s): Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, Nagashima Y, Nakagama H, Uozaki H, Fukayama M, Nakajima A
  • Journal Title: Oncol Rep 20(3) Pages: 479-488
• [Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility. (2008)
  • Author(s): Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, Inamori M, Kubota K, Saito S, Nakajima N, Wada K, Nagashima Y, Nakagama H
  • Journal Title: Cancer Sci 99(10) Pages: 1892-1900
• [Journal Article] Metformin suppresses intestinal polyp growth in Apc Min/+ mice. (2008)
  • Author(s): Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A
  • Journal Title: Cancer Sci 99(11) Pages: 2136-2141
  • NAID: 10024012700
• [Journal Article] Carcinoid tumor of the renal pelvis : Consideration on the histogenesis. (2008)
  • Author(s): Kuroda N, et al.
  • Journal Title: Pathol Int. 58(1) Pages: 51-54
  • Peer Reviewed
• [Journal Article] The inhibitory effect of Connexin 32 gene on metastasis in renal cell carcinoma. (2008)
  • Author(s): Sato H, et al.
  • Journal Title: Mol Carcinogenesis 47(6) Pages: 403-409
  • Peer Reviewed
• [Journal Article] The overexpression and altered localization of the atypical protein kinase C λ/ι in breast correlates with the pathological type of these tumors. (2008)
  • Author(s): Kojima Y, Nagashima Y (Correspondence), et al.
  • Journal Title: Hum Pathol. 39(6) Pages: 824-831
  • Peer Reviewed
• [Journal Article] Collecting duct carcinoma of the kidney : an immunohistochemical evaluation of the use of antibodies for differential diagnosis. (2008)
  • Author(s): Kobayashi N, Nagashima Y (Correspondence), et al.
  • Journal Title: Hum Pathol. 39(9) Pages: 1350-1359
  • Peer Reviewed
• [Journal Article] Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan. (2008)
  • Author(s): Sakuma Y, et al.
  • Journal Title: Cancer Lett. 259(2) Pages: 119-126
  • Peer Reviewed
• [Journal Article] 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. (2008)
  • Author(s): Hagiwara H, et al.
  • Journal Title: Br J Pharmacol. 153(7) Pages: 1373-1381
  • Peer Reviewed
• [Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal car (2008)
  • Author(s): Yao M, et al.
  • Journal Title: Int J Cancer 123(5) Pages: 1126-1132
  • Peer Reviewed
• [Journal Article] Chromophobe renal cell carcinoma and“capsuloma"with acquired cystic disease of the kidney in a long-term hemodialysis patient : a case report. (2008)
  • Author(s): Nishimura K, et al.
  • Journal Title: Int J Urol. 15(6) Pages: 543-545
  • Peer Reviewed
• [Journal Article] Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration. (2008)
  • Author(s): Kumamoto T, et al.
  • Journal Title: Liver Int. 28(6) Pages: 865-877
  • Peer Reviewed
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. (2008)
  • Author(s): Fujita K, et al.
  • Journal Title: Gut. 57(11) Pages: 1583-1591
  • Peer Reviewed
• [Journal Article] Antitumour effect of electrochemotherapy with bleomycin on human prostatic cancer xenog (2008)
  • Author(s): Ueki T, et al.
  • Journal Title: Brit J Urol BJU Int. 102(10) Pages: 1467-1471
  • Peer Reviewed
• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : implications for human disease. (2008)
  • Author(s): Kirino M, et al.
  • Journal Title: J Allergy Clin Immunol. 122(2) Pages: 290-297
  • Peer Reviewed
• [Journal Article] Malignant Mullerian tumor (carcinosarcoma)in mixed epithelial and stromal tumor of the kidney : A morphological and molecular genetic study. (2008)
  • Author(s): Kuroda N, Nagashima Y, et al.
  • Journal Title: APMIS 116(11) Pages: 1013-1015
  • Peer Reviewed
• [Journal Article] Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model. (2008)
  • Author(s): Yamaguchi J, et al.
  • Journal Title: J Invest Dermatol. 128(12) Pages: 2842-2849
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors, AdipoRl and AdipoR2, in normal colon epithelium and colon cancer tissue. (2008)
  • Author(s): Yoneda K, et al.
  • Journal Title: Oncol Rep. 20(3) Pages: 479-488
  • Peer Reviewed
• [Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility. (2008)
  • Author(s): Nakajima A, et al.
  • Journal Title: Cancer Sci. 99(10) Pages: 1892-1900
  • Peer Reviewed
• [Journal Article] Metformin suppresses intestinal polyp growth in Ape Min/+mice. (2008)
  • Author(s): Tomimoto A, et al.
  • Journal Title: Cancer Sci. 99(11) Pages: 2136-2141
  • Peer Reviewed
• [Journal Article] The co-expression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.
  • Author(s): Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano J-y, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H
  • Journal Title: Cancer Sci in press
  • NAID: 10030242512
• [Presentation] 腎腫瘍up to date (2011)
  • Author(s): 長嶋洋治
  • Organizer: 第2回神奈川県泌尿器科病理勉強会
  • Place of Presentation: 関内新井ホール(神奈川)(招待講演)
  • Year and Date: 2011-02-19
• [Presentation] ここが変わった, 腎癌取り扱い規約 (2011)
  • Author(s): 長嶋洋治
  • Organizer: 第52回日本病理学会近畿支部会学術集会
  • Place of Presentation: 兵庫医科大学(兵庫)(招待講演)
  • Year and Date: 2011-02-19
• [Presentation] 腎腫瘍病理診断のHOW TO. (2011)
  • Author(s): 長嶋洋治
  • Organizer: 第13回秋田県尿路腫瘍研究会,第77回秋田県泌尿器科集談会
  • Place of Presentation: 秋田パークホテル(秋田)(招待講演)
  • Year and Date: 2011-01-29
• [Presentation] 腎腫瘍up to date 2010s. (2011)
  • Author(s): 長嶋洋治
  • Organizer: 第39回東京泌尿器放射線画像勉強会
  • Place of Presentation: 六本木ヒルズ(東京)(招待講演)
  • Year and Date: 2011-01-08
• [Presentation] 腎腫瘍up to date 2010s. (2010)
  • Author(s): 長嶋洋治
  • Organizer: 日本病理学会九州沖縄支部第318回スライドコンファレンス(学術講演)
  • Place of Presentation: 熊本大学医学部(熊本)(招待講演)
  • Year and Date: 2010-11-06
• [Presentation] 腎腫瘍の新分類と分子生物学 (2010)
  • Author(s): 長嶋洋治
  • Organizer: Meet the specialist in urology and pathology
  • Place of Presentation: フォーシーズンズ椿山荘(東京)(招待講演)
  • Year and Date: 2010-10-07
• [Presentation] 細胞極性因子aPKCλによる上皮前駆細胞の増殖制御とその破綻 (2010)
  • Author(s): 秋本和憲, 他
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2010-10-07
• [Presentation] aPKC and IL-6 expression in prostate cancer tissues. (2010)
  • Author(s): 石黒斉, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Atypical protein kinase Cλ/ιregulates mouse mammary progenitor cell propagation. (2010)
  • Author(s): Akimoto K, et.al.
  • Organizer: 6th International Symposium on Hormonal Oncogenesis
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル(千葉)
  • Year and Date: 2010-09-12
• [Presentation] 腎腫瘍の病理学と分子生物学 (2010)
  • Author(s): 長嶋洋治
  • Organizer: 腎癌フォーラム2010
  • Place of Presentation: 名古屋マリオットアソシアホテル(愛知)(招待講演)
  • Year and Date: 2010-07-01
• [Presentation] Long-term high-fat diet loading induced steatohepatitis and hepatocellular carcinoma in a mouse model. (2010)
  • Author(s): Nakamura M, et.al
  • Organizer: 70th Scientific Sessions for American Diabetes
  • Place of Presentation: Orlando, FL, U.S.A.
  • Year and Date: 2010-06-25
• [Presentation] 放射線科医が知っておきたい腎腫瘍の病理 (2010)
  • Author(s): 長嶋洋治
  • Organizer: 第24回腹部放射線研究会基調講演2
  • Place of Presentation: 軽井沢プリンスホテル(長野)(招待講演)
  • Year and Date: 2010-06-12
• [Presentation] Anionic Pulmonary Surfactant Lipids Inhibit Influenza A Induced Inflammation and Infection. (2010)
  • Author(s): Nakamura M, et.al
  • Organizer: 2010 American Thoracic Society International Conference
  • Place of Presentation: New Orlean, LA, U.S.A.
  • Year and Date: 2010-05-15
• [Presentation] ndothelial nitric oxide synthase changes the fat distribution in high-fat diet-induced NAFLD mice. (2010)
  • Author(s): Nozaki Y, et.al
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orlean, LA, U.S.A.
  • Year and Date: 2010-05-02
• [Presentation] CD100/Sema4D, a lymphocyte semaphorin involved in the regulation of cell motility in pancreatic cancer. (2010)
  • Author(s): Kato S, et.al
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orlean, LA, U.S.A.
  • Year and Date: 2010-05-02
• [Presentation] 医学科高学年における病理学教育 (2010)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第99回日本病理学会春季総会(ワークショップ「明日の病理学教育」)
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2010-04-29
• [Presentation] ヒト腎癌組織分類と今後の問題点 (2010)
  • Author(s): 長嶋洋治
  • Organizer: 第99回日本病理学会春季総会ランチョンセミナー「遺伝性腎癌ラット"Nihon rat"発見10周年記念」
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2010-04-27
• [Presentation] 胃癌におけるaPKCλ/ιの高発現は再発の危険因子である (2010)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] Atypical protein kinase Cλ/ι regulates mouse mammary progenitor cell propagation. (2010)
  • Author(s): Akimoto K, Zheng Y-W, Nagashima Y, Ishiguro H, Asai-Sato M, Kojima Y, Li B, Sasaki K, Kagawa E, Kim M, Taniguchi H, Noda T, Ohno S
  • Organizer: 6th International Symposium on Hormonal Oncogenesis
  • Place of Presentation: Tokyo
• [Presentation] ベリニ管癌の網羅的ゲノム解析 (2010)
  • Author(s): 井上享, 成松隆弘, 中田知里, 松浦恵子, 佐藤文憲, 長嶋洋治, 矢尾正祐, 窪田吉信, 羽渕友則、大山力, 西山博之、小川修, 中川正之, 守山正胤, 三股浩光
  • Organizer: 第19回泌尿器科分子・細胞研究会
  • Place of Presentation: 神戸
• [Presentation] 胃癌におけるaPKCλ/ιの高発現は再発の危険因子である (2010)
  • Author(s): 長嶋洋治, 山中正二, 村上あゆみ, 稲山嘉明, 青木一郎
  • Organizer: 第99回日本病理学会春季総会
  • Place of Presentation: 東京
• [Presentation] aPKC and IL-6 expression in prostate cancer tissues. (2010)
  • Author(s): 石黒斉, 秋本和憲, 長嶋洋治, 加川絵理子, 佐々木毅, 佐野仁勇, 高川亮, 佐々木和教, 藤浪潔, 青木一郎, 大野茂男, 窪田吉信, 上村博司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 細胞極性因子aPKCλによる上皮前駆細胞の増殖制御とその破綻 (2010)
  • Author(s): 秋本和憲, 鄭允文, 長嶋洋治, 石黒斉, 佐々木和教, 金民大, 李文武, 角和卓, 谷口英樹, 野田哲生, 大野茂男
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会 ワークショップ「上皮細胞の機能とその破綻がもたらす病態のメカニズム」
  • Place of Presentation: 神戸
• [Presentation] The overexpression of the atypical protein kinase Cλ/τ in malignant melanoma correlates with its undifferentiation state and metastatic ability (2009)
  • Author(s): Miwa H, et al
  • Organizer: 4th Annual Meeting of the Japanese Society for Investig ative Dermatology
  • Place of Presentation: JAL福岡リゾートシーフォークホテル
  • Year and Date: 2009-12-05
• [Presentation] Endothelial nitric oxide synthase changes the fat distribution in high-fat diet-induced NAFLD mice (2009)
  • Author(s): Nozaki Y, et.al
  • Organizer: GASTRO2009 UEGW/WCOG
  • Place of Presentation: London, UK
  • Year and Date: 2009-11-23
• [Presentation] 副鼻腔原発 lipid-rich carcinoma の細胞学的所見 (2009)
  • Author(s): 大城久, 他
  • Organizer: 第48回日本臨床細胞学会秋期大会
  • Place of Presentation: JAL福岡リゾートシーフォークホテル
  • Year and Date: 2009-10-31
• [Presentation] 腎腫瘍の病理学と分子生物学-最近の話題と今後の展開- (2009)
  • Author(s): 長嶋洋治
  • Organizer: 第3回東京泌尿器病理学セミナー
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] Expression of CXCR3 variant in ovarian neoplasms (2009)
  • Author(s): Furuya M
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum (2009)
  • Author(s): Ichikawa Y, et al
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] Construction of the gene expression signature model for predict of patient outcome with clear cell renal carcinoma (2009)
  • Author(s): Takagawa R, et al
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] 泌尿器科医のための腎腫瘍病理学 (2009)
  • Author(s): 長嶋洋治
  • Organizer: 第1回愛宕GUフォーラム
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2009-09-24
• [Presentation] The overexpression and altered localization of the atypical protein kinase Cλ/τ in breast cancers (2009)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2009-08-27
• [Presentation] 病理医, 泌尿器科医のための, 腎腫瘍の病理学と分子生物学 (2009)
  • Author(s): 長嶋洋治
  • Organizer: 第7回東北泌尿器CPC
  • Place of Presentation: 法華クラブ(仙台)
  • Year and Date: 2009-07-25
• [Presentation] WT1遺伝子のexon10のナンセンス変異を認め腎移植に至った1例 (2009)
  • Author(s): 村上あゆみ, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] ヒト前立腺癌細胞と脂肪細胞との相互作用について (2009)
  • Author(s): 上大介, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] Collecting duct carcinoma of the kidney. An immunohistochemical study of 17 cases (2009)
  • Author(s): 長嶋洋治, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察 (2009)
  • Author(s): 古賀俊輔, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] 脾炎症性偽腫瘍の一例 (2009)
  • Author(s): 堀眞由美, 他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] Improvement of sensitivity to vinblastine by restoration of connexin 32 gene in renal cell carcinoma cells (2009)
  • Author(s): Takano Y, et.al
  • Organizer: 100^<th> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Denver, CO
  • Year and Date: 2009-04-20
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum (2009)
  • Author(s): Ichikawa Y, et.al
  • Organizer: 100^<th> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Denver, CO
  • Year and Date: 2009-04-19
• [Presentation] 前立腺癌におけるaPKCの発現と前立腺癌進展機構 (2009)
  • Author(s): 石黒斉, 他
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2009-04-16
• [Presentation] A three gene expression signature model to predict clinical outcome of clear cell renal carcinoma. (2009)
  • Author(s): Huang Y, Shioi K, Hattori K, Murakami T, Sano, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Kubota Y, Yao M
  • Organizer: The 2nd International Workshop co-sponsored by Yokohama City University and FDA (United States Food and Drug Administration). Biomarkers for development of biological products and new therapy.
  • Place of Presentation: Yokohama
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum. (2009)
  • Author(s): Ichikawa Y, Kojima Y, Ishikawa T, Shimizu D, Goto A, Hirokawa S, Kijima M, Yamamoto H, Suwa H, Yamagishi S, Osada S, Ota M, Fujii S, Endo I, Shimada H, Akimoto K, Nagashima Y, Ohno S
  • Organizer: 100th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Denver
• [Presentation] Improvement of sensitivity to vinblastine by restoration of connexin 32 gene in renal cell carcinoma cells. (2009)
  • Author(s): Takano Y, Iwata H, Sato H, Okuzawa H, Yamada R, Nagashima Y, Yamaura K, Ueno K, Yano T
  • Organizer: 100th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Denver
• [Presentation] Endothelial nitric oxide synthase changes the fat distribution in high-fat diet-induced NAFLD mice. (2009)
  • Author(s): Nozaki Y, Fujita K, Yoneda M, Mawatari H, Shinohara Y, Imajo K, Endo H, Hosono K, Yakahashi H, Kirikoshi H, Abe Y, Kobayashi N, Inamori M, Kubota K, Nagashima Y, Saito S, Nakajima A
  • Organizer: GASTRO2009 UEGW/WCOG
  • Place of Presentation: London
• [Presentation] 腎癌におけるaquapolin 1遺伝子発現とその診断的有用性,臨床応用についての検討 (2009)
  • Author(s): 矢尾正祐, 黄榮, 村上貴之, 佐野太, 近藤慶一, 中井川昇, 岸田健, 長嶋洋治, 窪田吉信
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
• [Presentation] 淡明細胞型腎癌におけるMET蛋白の機能の多様性 (2009)
  • Author(s): 中井川昇, 矢尾正祐, 和田朋子, 長嶋洋治, 窪田吉信
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
• [Presentation] 透析腎癌の網羅的ゲノム解析 (2009)
  • Author(s): 吉本多一郎, 松浦恵子, 中田知里, 成松隆弘, 井上享, 瀬戸加大, 長嶋洋治, 佐藤文憲, 守山正胤, 三股浩光
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
• [Presentation] 前立腺癌におけるaPKCの発現と前立腺癌進展機構 (2009)
  • Author(s): 石黒斉, 秋本和憲, 長嶋洋治, 小島康幸, 佐々木毅, 上村博司, 大野茂男, 窪田吉信
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
• [Presentation] The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancers. (2009)
  • Author(s): 長嶋洋治, 稲山嘉明, 山中正二, 佐々木毅, 青木一郎
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum. (2009)
  • Author(s): Ichikawa Y, Kojima Y, Nagashima Y, Akimoto K, Ishikawa T, Goto A, Hirokawa S, Yamagishi S, Ota M, Fujii S, Nakajima A, Endo I, Ohno S
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Clinical significance of typical protein kinase iota expression in gastric cancer. (2009)
  • Author(s): Takagawa R, Nagashima Y, Akimoto K, Akiyama H, Ono H, Kimura J, Ichikawa Y, Endo I
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Construction of the gene expression signature model for predict of patient outcome with clear cell renal carcinoma. (2009)
  • Author(s): Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kuboya Y, Nagashima Y, Yao M
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] The overexpression of the atypical protein kinase C λ/ι in malignant melanoma correlates with its undifferentiation state and metastatic ability. (2009)
  • Author(s): Miwa H, Akimoto K, Inoue Y, Wada H, Ishiguro H, Ohno S, Nagashima Y, Ikezawa Z
  • Organizer: 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 福岡
• [Presentation] 子宮平滑筋腫におけるエリスロポエチンの血管増生作用に関する研究-平滑筋腫はなぜ巨大化できるか? (2009)
  • Author(s): 佐藤美紀子, 他
  • Organizer: 第8回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 福岡
• [Presentation] Collecting duct carcinoma of the kidney. An immunohistochemical study for differential diagnosis. (2008)
  • Author(s): 長嶋洋治
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-14
• [Presentation] 中央病理診断による腎細胞癌患者の予後調査一第一報. (2008)
  • Author(s): 伊藤哲之, 他
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-31
• [Presentation] Collecting duct carcinoma of the kidney ; an immunohistochemical evaluation of 17 cases. (2008)
  • Author(s): Nagashima Y, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] The study for the tumor suppression effect of Connexin 32 gene between a chemotherapeu (2008)
  • Author(s): Takano Y, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] A three-gene expression signature model to predict clinical outcome of clear cell renal car (2008)
  • Author(s): Yao M, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Expression of aquaporin 1 in primary renal tumors ; A prognostic indicator for clear cell RC (2008)
  • Author(s): Huang Y, et al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Comparison of ultrasonography and MRI assessment of synovitis with histopathological findings in patients with osteoarthritis and rheumatoid arthritis. (2008)
  • Author(s): Takase K, et al.
  • Organizer: The 72th Annual Scientific Meeting of American College of Rheumatology
  • Place of Presentation: San Francisco, CA
  • Year and Date: 2008-10-27
• [Presentation] Heme oxygenase 1 attenuates the development of atopic dermatitis. (2008)
  • Author(s): 桐野実緒, 他
  • Organizer: 第36回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] 再生医療と病理 (2008)
  • Author(s): 長嶋洋治
  • Organizer: 平成20年度厚生労働省科学研究費補助金政策創薬総合研究推進事業研究成果等普及啓発事業研究成果発表会市民公開講座
  • Place of Presentation: 葉山
  • Year and Date: 2008-08-03
• [Presentation] 腎上皮性腫瘍の新組織分類-病理学と分子生物学的側面から- (2008)
  • Author(s): 長嶋洋治
  • Organizer: 第49回日本臨床細胞学会(春季大会)教育講演
  • Place of Presentation: 東京
  • Year and Date: 2008-06-07
• [Presentation] Epithelioid angiomyolipoma. A report ofthree cases. (2008)
  • Author(s): 長嶋洋治
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Presentation] The status of aPKCλ/ι in breast cancer correlates with the pathologic types. (2008)
  • Author(s): 長嶋洋治, 稲山嘉明, 佐々木毅, 大城久, 村上あゆみ, 山中正二, 河内香江, 野澤昭典, 青木一郎
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] The role of aPKC lambda in prostate cancer progression. (2008)
  • Author(s): Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Ishiguro Y, Sasaki T, Uenura H, Ohno S, Kubota Y
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Book] 第1章 腎癌.2病因・病理(2)病理木原和徳(編):最新医学 別冊 新しい診断と治療のABC 45腎癌・膀胱癌(第2版) (2011)
  • Author(s): 長嶋洋治, 他
  • Publisher: 最新医学社(大阪)(印刷中)
• [Book] 第14章腎・尿路系,「ロビンス基礎病理学」(第8版),高橋雅英,豊國伸哉(監訳) (2011)
  • Author(s): 長嶋洋治(分担訳)
  • Publisher: エルゼビア・ジャパン社(東京)(印刷中)
• [Book] 腎細胞癌, 南山堂医学大辞典 (2011)
  • Author(s): 長嶋洋治(分担)
  • Publisher: 南山堂(東京)(印刷中)
• [Book] Molecular mechanism and Morphology in Cancer(Pathology and molecular biology of renal neoplasms. Recent advances and impacts on pathological classification.)(Nakamura M, Kakudo K (eds.)) (2009)
  • Author(s): Nagashima Y, Kobayashi N, Kagawa E, Aoki I, Inayama Y, Yao M
  • Publisher: Bentham Science Publishers E-Book
• [Book] RCCの分類-変遷と現状- (2008)
  • Author(s): 長嶋洋治, 他
  • Publisher: メジカルレビュー社
• [Book] 腎細胞癌, 膀胱炎. 笹野公伸, 真鍋俊明(編集). 病理画像ケーススタディ(CD媒体) (2008)
  • Author(s): 長嶋洋治, 他
  • Publisher: 南山堂
• [Book] 第14章腎臓, 第15章尿路, 下正宗(編)正常画像と並べてわかる病理アトラス (2008)
  • Author(s): 長嶋洋治, 他
  • Publisher: 羊土社
• [Remarks] ホームページ等
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