| Project/Area Number |
20590368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAGASHIMA Yoji Yokohama City University, 医学研究科, 准教授 (10217995)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Kazunori 横浜市立大学, 医学部, 助教 (70285104)
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| Co-Investigator(Renkei-kenkyūsha) |
CHISHIMA Takashi 横浜市立大学, 附属病院, 准教授 (70438141)
ISHIKAWA Takashi 立大学, 市民総合医療ンター, 准教授 (80275049)
UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439)
ISHIGURO Hitoshi 横浜市立大学, 医学研究科, 客員准教授 (00381666)
KANNO Hiroshi 横浜市立大学, 医学部, 准教授 (40244496)
AOKI Ichiro 横浜市立大学, 医学研究科, 教授 (00184028)
INAYAMA Yoshiaki 横浜市立大学, 附属病院, 教授 (10184730)
NOZAWA Akinori 横浜市立大学, 市民総合医療センター, 准教授 (00228321)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞極性 / aPKC-PAR系 / 乳癌 / 前立腺癌 |
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| Research Abstract |
aPKCλ/ιhas a pivotal role in establishment and maintenance of cell polarity. In this study, we demonstrated that (1) aPKCλ/ιis overexpressed in various cancer cells, including breast and prostate cancers, (2) aPKCλ/ιinduces IL6 expression to obtain castration resistance in prostatic cancer (aPKC-IL6 pathway), and (3) correlation of expression of aPKCλ/ι and IL6 was demonstrated in the breast cancer as well as prostatic cancer.
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