Investigation for application of Terahertz-Wave spectroscopy to high-accurated histopathological analysis
| Project/Area Number |
20590369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
MIURA Yasuhiro Iwate Medical University, 医学部, 助教 (40398483)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 診断病理学 / 病理診断技術 / テラヘルツ/赤外材料・素子 / 細胞・組織 / 病理学 / テラヘルツ / 赤外材料・素子 / テラヘルツ波 / 病理組織解析 / 病理組織イメージング |
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| Research Abstract |
By using Terahertz-Wave spectroscopy which has the following characteristics : 1) going straight and transmittance, 2) easy to obtain the wave for imaging, 3) having molecular-specific "fingerprint wave", and 4) non invasive to human body, different from X-ray, we performed the high-accurated histopathological analysis. Results we obtained were follows ;
1) Terahertz-wave spectroscopy for precise histopathological image analysis using paraffin-embedded sections.Miura Y, et al : Tohoku J Exp Med. 223 : 291-6(2011)
2) Terahertz-wave spectroscopy applicable for intraoperative quick diagnosis using fresh frozen specimen ( in preparation)
3) In analyze the histological factors which influence the transmittance of Terahertz-Wave, it was demonstrated that the factors related on transmittance of Terahertz-Wave depend on not only the density of cell/tissue, but also the conditions such as inflammation, nectrosis and fibrosis and so on.
4) Application of Terahertz-wave spectroscopy for Immunohistochemical staining which is able to be analyze both the chemical component as well as histopathological features.
From our results for three years, the terahertz-wave spectroscopy would be a useful tool for high-accurated histopathological and chemical analyses.
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Report
(4 results)
Research Products
(10 results)
