| Project/Area Number |
20590370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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|---|
| Research Institution | Iwate Medical University |
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Principal Investigator |
MASUDA Tomoyuki Iwate Medical University, 医学部, 教授 (10199698)
|
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| Co-Investigator(Kenkyū-buntansha) |
MAESAWA Chihaya 岩手医科大学, 医学部, 教授 (10326647)
OIKAWA Hiroki 岩手医科大学, 医, 講師 (50285582)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 肝 / 線維症 / 星細胞 / miRNA / epigenetics / 肝線維症 / 肝星細胞 / ギガシークエンサー / 肝炎 / 肝硬変 / エピジェネティックス |
|---|
| Research Abstract |
We intensively examined on hepatic stellate cells (HSC) for the treatment strategy of liver fibrosis. The present study focused on epigenetic alterations within the process of HSCs transformation. Using Gia-base sequencing method, global alterations of DNA methylation were examined in HSC under the condition of HDAC inhibitor (TSA) and interferon (IFN)-γ. Of them, genes relating pluripotency of stem cells were altered, and the nucleus accumbens associated-1 (NACC1) might be an important factor along with cMYC and NANOG. These transition of HSC might be induced though epigenetic alterations.
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