| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Research Abstract |
In this study, we present that
i) abnormal chromosome territories (CTs) of the CS10, CS18, and CS19 in thyroid carcinomas.
ii) relation between of nuclear atypia and number of chromosomes/genes in urothelial carcinomas of the urinary bladder.
iii) change of subchromosomal positioning (SCP) of epidermal differentiation complex (EDC) gene in CT of chromosome 1 in squamous cell metaplasia of the uterine cervix.
iv) less condensation of DNA around EDC gene in chromosome 1 of squamous cell metaplasia of the uterine cervix.
From the above results, we concluded that higher-order or angstrom level alteration of chromosomes and DNA architecture could be related to cell morphology through RNA transcription activity change.
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