Molecular mechanisms of invasion and metastasis in bone and soft-tissue sarcomas.
| Project/Area Number |
20590375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
SAITO Tsuyoshi Juntendo University, 医学部, 助教 (80439736)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性骨軟部腫瘍 / 転移・浸潤 / 分子治療標的 / 肉腫 / 治療抵抗性 / 分子標的治療 / 骨軟部腫瘍 / 浸潤・転移 / キメラ融合遺伝子 / RNAi / リセプター型チロシンキナーゼ |
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| Research Abstract |
We identified EWS-WT1(KTS+) fusion gene as a novel therapeutic target in desmoplastic small round cell tumor. Furthermore, exogenous expression of EWS-WT1(KTS+) in HeLa cells resulted in the acquisition of epithelial characteristics as evidenced by E-cadherin and β-catenin expression. Identification of p53 mutation in giant-cell tumor of bone might be a molecular pathological marker for malignant transformation of this tumor.
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Report
(4 results)
Research Products
(30 results)
