Diagnosis of Oral Intraepithelial Neoplasia and Study for Mucosal Tissue Stem Cells Using Our Original Tissue Q-FISH Method.
| Project/Area Number |
20590378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
AIDA Junko Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 (80425678)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Ken-Ichi 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所・老年病理学研究チーム, 研究員 (60159069)
IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所・老年病理学研究チーム, 助手 (10158751)
TAKUBO Kaiyo 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所・老年病理学研究チーム, 研究部長 (00154956)
IZUMO Toshiyuki 埼玉県立がんセンター, 臨床腫瘍研究所, 研究員 (80322709)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 診断病理学 / テロメア / 老化 / 病理学 / 癌 / トランスレーショナルリサーチ / 組織幹細胞 |
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| Research Abstract |
We can measure the teIomere length in each cell group on the slide by using our original tissue Q-FISH method. In analysis of oral mucosa, we could confirm that the basal cells have the longest telomeres among the epithelial layer, and that suggests the tissue stem cells are reside in the basal layer. We could also have proved some dysplastic lesions as kinds of carcinoma in situ, because of having short telomeres as same pattern as mucosal carcinomas. The epithelia adjacent to carcinomas or some leukoplakias have significantly short telomeres and chromosomal instabilities, therefore, these lesions might be the true precancerous lesions.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Telomere length in the esophagus of alcoholics measured by Q-FISH.2011
Author(s)
Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sqwabe M, Matsuura M, Arai T, Takubo K
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Journal Title
J Pathol 223(3)
Pages: 410-416
Related Report
Peer Reviewed
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[Journal Article] Telomere lengths in the oral epithelia with and without carcinoma.2010
Author(s)
Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fujiwara M, Sawabe M, Arai T, Takubo K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ.2010
Author(s)
Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J
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Journal Title
J Pathol 221(2)
Pages: 201-9
Related Report
Peer Reviewed
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[Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence.2010
Author(s)
Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon S.S.S, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird D.M, Nakamura K
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Journal Title
Mech Age Dev 131
Pages: 614-624
Related Report
Peer Reviewed
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[Journal Article] Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.2008
Author(s)
Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Kammori M, Sawabe M, Arai T, Matsuura M, Fujiwara M, Kishimoto H, Takubo K
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Journal Title
Exp Gerontol 43
Pages: 833-839
URL
Related Report
Peer Reviewed
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