Role of drs tumor suppressor gene on host defense mechanism against infection

• Project/Area Number: 20590383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: TAMBE Yukihiro Shiga University of Medical Science, 医学部, 助教 (50283560)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: drs遺伝子 / 感染防御 / 自然免疫 / mTOR / GADD34 / 感染防御作用

Research Abstract

To clarify the physiological function of drs tumor suppressor in non-malignant cells, the role on host defense against infection was investigated. The replication of the viruses including VSV in drs deficient cells, derived from drs knockout mice, was increased compared with that in wild-type cells. drs was associated with stress-inducible GADD34 and TSC2, and regulated mTOR signaling pathway to suppress the viral protein synthesis in the infected cells. It was suggested that drs is involved in the host defense mechanism against viral infection.

Research Products

• [Journal Article] Opposite regulation of epithelial to mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells. (2011)
  • Author(s): Chul Jang Kim, Kanami Sakamoto, Yukihiro Tambe, Hirokazu Inoue.
  • Journal Title: Int J Oncol.Vol. 38 Pages: 1759-1766
  • Peer Reviewed
• [Journal Article] Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells. (2011)
  • Author(s): Kim, C.J., Sakamoto, K., Tambe, Y., Inoue, H.
  • Journal Title: Int.J.Oncol. Volume: 38 Pages: 1759-1766
  • Peer Reviewed
• [Journal Article] Cyclin D1b variant promotes cell invasiveness independent of binding to CDK in human bladder cancer cells. (2009)
  • Author(s): Chul Jang Kim, Kayoko Nishi, Takahiro Isono, Yusuke Okuyama, Yukihiro Tambe, Yusaku Okada, Hirokazu Inoue.
  • Journal Title: Mol.Carcinog. Vol.48 Pages: 953-964
  • Peer Reviewed
• [Journal Article] The Drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. (2009)
  • Author(s): Yukihiro Tambe, Akitsugu Yamamoto, Takahiro Isono, Tokuhiro Chano, Mitsunori Fukuda, Hirokazu Inoue.
  • Journal Title: Cancer Letters Vol.283 Pages: 74-83
  • Peer Reviewed
• [Journal Article] The Drs tumor suppressor is involved in the maturation process of autophagy induced by low serum (2009)
  • Author(s): Tambe, Y., Yamamoto, A., Isono, T., Chano, T., Fukuda, M., Inoue, H.
  • Journal Title: Cancer Letters 283 Pages: 74-83
  • Peer Reviewed
• [Journal Article] Cyclin D1b variant promotes cell invasiveness independent of binding to CDK in human bladder cancer cells (2009)
  • Author(s): Kim, C.J., Nishi, K., Isono, T., Okuyama, Y., Tambe, Y., Okada, Y., Inoue, H.
  • Journal Title: Molecular Carcinogenesis 48 Pages: 953-964
  • Peer Reviewed
• [Journal Article] The Drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. (2009)
  • Author(s): Tambe, Y., Yamamoto, A., Isono, T., Chano, T., Fukuda, M., Inoue, H.
  • Journal Title: Cancer Letters (In press)
  • Peer Reviewed
• [Journal Article] Cyclin Dlb variant prpmotes cell invasiveness independent of binding to CDK in human bladder cancer cells. (2009)
  • Author(s): Kim, C. J., Nishi, K., Isono, T., Okuyama, Y., Tambe, Y., Okada, Y., Inoue, H.
  • Journal Title: Molecular Carcinogenesis (In press)
  • Peer Reviewed
• [Journal Article] Role of alternative splicing of periostin in human bladder carcinogenesis. (2008)
  • Author(s): Chul Jang Kim, Takahiro Isono, Yukihiro Tambe, Tokuhiro Chano, Hidetoshi Okabe, Yusaku Okada, Hirokazu Inoue.
  • Journal Title: Int.J.Oncol. Vol.32 Pages: 161-169
  • Peer Reviewed
• [Journal Article] Role of alternative splicing of periostin in human bladder carcinogenesis. (2008)
  • Author(s): Kim, C. J., Isono, T., Tambe, Y., Chano, T., Okabe, H., Okada, Y. Inoue, H.
  • Journal Title: Int. J. Oncol. 32 Pages: 161-169
  • Peer Reviewed
• [Presentation] Cell-type dependent regulation of EMT and cell invasiveness of human cancer cells by periostin (2010)
  • Author(s): Hirokazu Inoue, Kanami Sakamoto, Yukihiro Tambe, Chul Jang Kim
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Cell-type dependent regulation of EMT and cell invasiveness of human cancer cells by periostin (2010)
  • Author(s): Hirokazu Inoue, Kanami Sakamoto, Yukihiro Tambe, Chul Jang Kim
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: ポートアイランド(神戸)
  • Year and Date: 2010-12-10
• [Presentation] 癌抑制遺伝子drsによるウイルス増殖抑制作用 (2010)
  • Author(s): 旦部幸博, 奥山直美, 中川達也, 井上寛一
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] drsによるウイルス増殖抑制作用 (2010)
  • Author(s): 旦部幸博, 奥山直美, 中川達也, 井上寛一
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: ポートアイランド(神戸)
  • Year and Date: 2010-12-08
• [Presentation] The drs tumor suppressor is involved in the suppression of viral replication via p38-RSK1-S6 dependent pathway (2010)
  • Author(s): 旦部幸博, 茶野徳宏, 井上寛一.
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] The drs tumor suppressor is involved in the suppression of viral replication via p38-RSK1-S6 dependent pathway (2010)
  • Author(s): Yukihiro Tambe, Tokuhiro Chano, Hirokazu Inoue
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪(大阪)
  • Year and Date: 2010-09-23
• [Presentation] Cell-type dependent regulation of EMT and cell invasiveness of cancer cells by periostin (2010)
  • Author(s): Chul Jang Kim, Yukihiro Tambe, Hirokazu Inoue
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Cell-type dependent regulation of EMT and cell invasiveness of cancer cells by periostin (2010)
  • Author(s): Chul Jang Kim, Yukihiro Tambe, Hirokazu Inoue.
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Regulation of autophagy maturation by the interaction of Drs tumor suppressor and Rab24. (2009)
  • Author(s): 旦部幸博, 礒野高敬, 茶野徳宏, 井上寛一.
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-28
• [Presentation] Cyclin D1b variant enhances cell invasiveness of human bladder cancer cells. (2009)
  • Author(s): Chul Jang Kim, Takahiro Isono, Yukihiro Tambe, Yusaku Okada, Hirokazu Inoue
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-28
• [Presentation] Role of drs tumor suppressor gene in cell survival under energy depletion. (2009)
  • Author(s): 井上寛一, 茶野徳宏, 旦部幸博.
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Functional analysis of variant cyclin D1b on enhances cell invasiveness of human bladder cancer cells (2009)
  • Author(s): Chul Jang Kim, Takahiro Isono, Yukihiro Tambe, Yusaku Okada, Hirokazu Inoue
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Role of drs tumor suppressor gene in cell survival under energy depletion (2009)
  • Author(s): Hirokazu Inoue, Tokuhiro Chano, Yukihiro Tambe
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Suppression of viral replication by the drs tumor suppressor genes. (2009)
  • Author(s): 旦部幸博, 井上寛一.
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Suppression of viral replication by the drs tumor suppressor genes (2009)
  • Author(s): Yukihiro Tambe, Hirokazu Inoue
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] エネルギー枯渇に対するストレス応答における癌抑制遺伝子drs の役割 (2008)
  • Author(s): 旦部幸博、前田理亜、山本章嗣、茶野徳宏、井上寛一
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] エネルギー枯渇に対するストレス応答における癌抑制遺伝子drsの役割 (2008)
  • Author(s): 旦部幸博, 前田理亜, 山本章嗣, 茶野徳宏, 井上寛一
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Splicing variant cyclin D1b による膀胱癌細胞の悪性化促進の解析 (2008)
  • Author(s): 井上寛一、西香代子、奥山雄介、旦部幸博、岡田裕作、礒野高敬、金哲將
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Splicing variant cyclin Dlbによる膀胱癌細胞の悪性化促進の解析 (2008)
  • Author(s): 井上寛一, 西香代子, 奥山雄介, 旦部幸博, 岡田裕作, 礒野高敬, 金哲將
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Regulation of autophagy maturation by the interaction of Drs tumor suppressor and Rab24. (2008)
  • Author(s): Yukihiro Tambe, Takahiro Isono, Tokuhiro Chano, Hirokazu Inoue.
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Cyclin Dlb variant enhances cell invasiveness of human bladder cancer cells. (2008)
  • Author(s): Chul Jang Kim, Takahiro Isono, Yukihiro Tambe, Yusaku Okada, Hirokazu Inoue.
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Remarks]
  • URL: http://www.shiga-med.ac.jp/~hqmicro/