Role of drs tumor suppressor gene on host defense mechanism against infection
| Project/Area Number |
20590383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TAMBE Yukihiro Shiga University of Medical Science, 医学部, 助教 (50283560)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | drs遺伝子 / 感染防御 / 自然免疫 / mTOR / GADD34 / 感染防御作用 |
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| Research Abstract |
To clarify the physiological function of drs tumor suppressor in non-malignant cells, the role on host defense against infection was investigated. The replication of the viruses including VSV in drs deficient cells, derived from drs knockout mice, was increased compared with that in wild-type cells. drs was associated with stress-inducible GADD34 and TSC2, and regulated mTOR signaling pathway to suppress the viral protein synthesis in the infected cells. It was suggested that drs is involved in the host defense mechanism against viral infection.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] The Drs tumor suppressor is involved in the maturation process of autophagy induced by low serum2009
Author(s)
Tambe, Y., Yamamoto, A., Isono, T., Chano, T., Fukuda, M., Inoue, H.
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Journal Title
Cancer Letters 283
Pages: 74-83
Related Report
Peer Reviewed
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[Journal Article] Cyclin D1b variant promotes cell invasiveness independent of binding to CDK in human bladder cancer cells2009
Author(s)
Kim, C.J., Nishi, K., Isono, T., Okuyama, Y., Tambe, Y., Okada, Y., Inoue, H.
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Journal Title
Molecular Carcinogenesis 48
Pages: 953-964
Related Report
Peer Reviewed
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[Journal Article] The Drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.2009
Author(s)
Tambe, Y., Yamamoto, A., Isono, T., Chano, T., Fukuda, M., Inoue, H.
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Journal Title
Cancer Letters (In press)
Related Report
Peer Reviewed
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[Journal Article] Cyclin Dlb variant prpmotes cell invasiveness independent of binding to CDK in human bladder cancer cells.2009
Author(s)
Kim, C. J., Nishi, K., Isono, T., Okuyama, Y., Tambe, Y., Okada, Y., Inoue, H.
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Journal Title
Molecular Carcinogenesis (In press)
Related Report
Peer Reviewed
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[Journal Article] Role of alternative splicing of periostin in human bladder carcinogenesis.2008
Author(s)
Kim, C. J., Isono, T., Tambe, Y., Chano, T., Okabe, H., Okada, Y. Inoue, H.
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Journal Title
Int. J. Oncol. 32
Pages: 161-169
Related Report
Peer Reviewed
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