Functional analysis of the ACAT-1-positive late endosomes in cholesterol-rich macrophages

• Project/Area Number: 20590384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kumamoto University
• Principal Investigator: SAKASHITA Naomi Kumamoto University, 大学院・生命科学研究部, 准教授 (90284752)
• Co-Investigator(Kenkyū-buntansha): TAKEYA Motohiro 熊本大学, 大学院・生命科学研究部, 教授 (90155052) ; KOMOHARA Yoshihiro 熊本大学, 大学院・生命科学研究部, 助教 (40449921) ; FUJIWARA Yukio 熊本大学, 大学院・生命科学研究部, 助教 (70452886)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 細胞 / マクロファージ / コレステロール / 異物貪食 / ACAT-1 / ファゴゾーム / 後期エンドゾーム / NPC1 / オルガネラ / ACAT1

Research Abstract

We functionally analyzed ACAT1-positive late endosomes (ACAT1-LE) which appears in cholesterol-rich macrophages. ACAT1-LE contributed effective cholesterol esterification, in addition, they showed impaired phagosomal maturation. Interestingly, such impairment partially correlated by pharmacological inhibition of cholesterol esterification.

Research Products

• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. (2011)
  • Author(s): Ohgami N, Ida-Eto M, Sakashita N, Sone M, Makashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takashasi M, Kato M.
  • Journal Title: Neurobiology of Aging in press
  • Peer Reviewed
• [Journal Article] Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. (2011)
  • Author(s): Fujiwara Y, Hayashida A, Tsurushima K,Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda T
  • Journal Title: Journal of Agricultural and Food Chemistry in press
  • Peer Reviewed
• [Journal Article] A case of pulmonary capillary hemangiomatosis with pulmonary fibrosis associated with MMP-9 related pulmonary remodeling. (2011)
  • Author(s): Sakashita N, Motooka Y, Suganuma M, Ohnishi K, Fujiwara Y, Nakagawa T, Ichiyasu H, Takeya M
  • Journal Title: Pathology International 61(5) Pages: 306-312
  • NAID: 10031185087
  • Peer Reviewed
• [Journal Article] Natural Compounds Containing a Catechol Group Enhance the Formation of N(ε)-(carboxymethyl)lysine of the Maillard Reaction. (2010)
  • Author(s): Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R
  • Journal Title: Free Radical Biological Medicine 50(7) Pages: 883-891
  • Peer Reviewed
• [Journal Article] 転移性肺腫瘍切除後Trastuzumab投与し4年間無再発乳癌の1例 (2010)
  • Author(s): 花田法久, 富山信博, 堀和樹, 草野秀一, 吉田泰司, 川田康誠, 内野良仁, 坂下直実
  • Journal Title: 癌と化学療法 37(13) Pages: 2905-2907
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010)
  • Author(s): Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America. 107(29) Pages: 13501-13506
  • Peer Reviewed
• [Journal Article] Association of ACAT1-positive vesicles with late endosomes/lysosomes in cholesterol-rich human macrophages. (2010)
  • Author(s): Lei XF, Fujiwara Y, Chang CCY, Chang TY, Takeya M, Sakashita N
  • Journal Title: Journal of Atherosclerosis and Thrombosis 17(7) Pages: 740-750
  • NAID: 130004444447
  • Peer Reviewed
• [Journal Article] Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. (2010)
  • Author(s): Sakashita N, Chang CC, Lei X, Fujiwara Y, Takeya M, Chang TY
  • Journal Title: Journal of Lipid Research 51(6) Pages: 1263-1272
  • Peer Reviewed
• [Journal Article] Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). (2010)
  • Author(s): Takemura K, Sakashita N, Fujiwara Y, Komohara Y, Lei X, Ohnishi K, Suzuki H, Kodama T, Mizuta H, Takeya M
  • Journal Title: Biochemical and Biophysical Research Communications 391(4) Pages: 1675-1680
  • Peer Reviewed
• [Journal Article] Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype-their possible involvement in pathological process-. (2010)
  • Author(s): Ohnishi K, Komohara Y, Sakashita N, Iyama K, Murayama T, Takeya M
  • Journal Title: Pathology International 60(1) Pages: 27-34
  • NAID: 10027382665
  • Peer Reviewed
• [Journal Article] Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype : their possible involvement in pathological processes. (2010)
  • Author(s): Ohnishi K
  • Journal Title: Pathology International Volume: 60 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). (2010)
  • Author(s): Takemura K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 391 Pages: 1675-1680
  • Peer Reviewed
• [Journal Article] Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. (2010)
  • Author(s): Sakashita N
  • Journal Title: Journal of Lipid Research Volume: 51 Pages: 1263-1272
  • Peer Reviewed
• [Journal Article] Association of ACAT1-positive vesicles with late endosomes/lysosomes in cholesterol-rich human macrophages.Association of ACAT1-positive vesicles with late endosomes/lysosomes in cholesterol-rich human macrophages. (2010)
  • Author(s): Lei X
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 17 Pages: 740-750
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010)
  • Author(s): Ohgami N
  • Journal Title: Proceeding of National Academy of Science USA Volume: 107 Pages: 13051-13056
  • Peer Reviewed
• [Journal Article] Natural Compounds Containing a Catechol Group Enhance the Formation of N(ε)-(carboxymethyl)lysine of the Maillard Reaction. (2010)
  • Author(s): Fujiwara Y
  • Journal Title: Free Radical Biological Medicine Volume: 50 Pages: 883-891
  • Peer Reviewed
• [Journal Article] A case of pulmonary capillary hemangiomatosis with pulmonary fibrosis associated with MMP-9 related pulmonary remodeling. (2010)
  • Author(s): Sakashita N
  • Journal Title: Pathology International Volume: (in press)
  • NAID: 10031185087
  • Peer Reviewed
• [Journal Article] Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. (2010)
  • Author(s): Fujiwara Y
  • Journal Title: Journal of Agricultural and Food Chemistry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. (2010)
  • Author(s): Ohgami N
  • Journal Title: Neurobiology of Aging Volume: (in press)
  • Peer Reviewed
• [Journal Article] Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype : their possible involvement in pathological processes (2010)
  • Author(s): Ohnishi K
  • Journal Title: Pathology International 60 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB(RANK) (2010)
  • Author(s): Takemura K
  • Journal Title: Biochemical and Biophysical Research Communications 391 Pages: 1675-1680
  • Peer Reviewed
• [Journal Article] Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity (2010)
  • Author(s): Sakashita N
  • Journal Title: Journal of Lipid Research (In press)
  • Peer Reviewed
• [Journal Article] Association of ACAT1-positive vesicles with late endosomes/lysosomes in cholesterol-rich human macrophages (2010)
  • Author(s): Lei XF
  • Journal Title: Journal of Athelosclerosis and Thrombosis (In press)
  • Peer Reviewed
• [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to up-regulation of nitric oxide and IFN-gamma production by tumor-associated macrophages. (2009)
  • Author(s): Komohara Y, Takemura K, Lei X, Sakashita N, Harada M, Suzuki H, Kodama T, Takeya M
  • Journal Title: Cancer Science 100(11) Pages: 2160-2166
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule. (2009)
  • Author(s): Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M
  • Journal Title: Journal of Dermatological Sciences 55(1) Pages: 68-70
  • NAID: 10025334344
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule (2009)
  • Author(s): Yajima I
  • Journal Title: Journal of Dermatological Sciences 55 Pages: 68-70
  • Peer Reviewed
• [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to up-regulation of nitric oxide and IFN-gamma production by tumor-associated macrophages (2009)
  • Author(s): Komohara Y
  • Journal Title: Cancer Science 100 Pages: 2160-2166
  • Peer Reviewed
• [Journal Article] Imatinib Mesylate低用量投与後に切除した胃Gastrointestinal Stromal Tumorの1例 (2008)
  • Author(s): 堀和樹, 花田法久, 草野秀一, 鶴本泰之, 坂下直実, 内野良仁
  • Journal Title: 癌と化学療法 35(10) Pages: 1749-1751
  • Peer Reviewed
• [Journal Article] Pioglitazone, a peroxisome proliferator-activated receptor-g agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders. (2008)
  • Author(s): Honda T, Kaikita K, Tsujita K, Hayasaki T, Matsukawa M, Fuchigami S, Sugiyama S, Sakashita N, Ogawa H, Takeya M
  • Journal Title: Journal of molecular cell cardiology 44(5) Pages: 915-926
  • Peer Reviewed
• [Journal Article] Differentiation of mouse and human ES cells into hepatic lineages. (2008)
  • Author(s): Shiraki N, Umeda K, Sakashita N, Takeya M, Kume K, Kume S
  • Journal Title: Genes Cells 13(7) Pages: 731-746
  • NAID: 120002468594
  • Peer Reviewed
• [Journal Article] Specific pathogen free conditions prevent transthyretin amyloidosis in mouse models. (2008)
  • Author(s): Inoue S, Ohta M, Li Z, Zhao G, Takaoka Y, Sakashita N, Miyakawa K, Takada K, Tei H, Suzuki M, Masuoka M, Sakaki Y, Takahashi K, Yamamura KI
  • Journal Title: Transgenic Research 17(5) Pages: 817-826
  • Peer Reviewed
• [Journal Article] Leiomyomatoid angiomatous neuroendocrine tumor of the myometrium : case study with ultrastructural analysis. (2008)
  • Author(s): Sakashita N, Yamada M, Nakagawa T, Yamasaki H, Takeya M
  • Journal Title: Human Pathology 39(5) Pages: 788-792
  • Peer Reviewed
• [Journal Article] Immunochemical detection of Ne-(carboxyethyl)lysine using a specific antibody. (2008)
  • Author(s): Nagai R, Fujiwara Y, Mera K, Yamagata K, Sakashita N, Takeya M.
  • Journal Title: Journal of Immunological Methods 332(1-2) Pages: 112-120
  • Peer Reviewed
• [Journal Article] (*equal contribution) : Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor. (2008)
  • Author(s): Hiyoshi M, Suzu S, Yoshidomi Y, Hassan R, Harada H, Sakashita N, Akari H, Motoyoshi K, Okada S
  • Journal Title: Blood 111(1) Pages: 243-250
  • Peer Reviewed
• [Journal Article] Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor. (2008)
  • Author(s): Hiyoshi M
  • Journal Title: Blood 111 Pages: 243-250
  • Peer Reviewed
• [Journal Article] Immunochemical detection of N(epsilon)-(carboxyethyl)lysine using a specific antibody. (2008)
  • Author(s): Nagai R
  • Journal Title: J Immunol Methods 332 Pages: 112-120
  • Peer Reviewed
• [Journal Article] A leiomyomatoid angiomatous neuroendocrine tumor of the myometrium : case study with ultrastructural analysis. (2008)
  • Author(s): Sakashita N
  • Journal Title: Hum Pathol 39 Pages: 788-792
  • Peer Reviewed
• [Journal Article] Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders. (2008)
  • Author(s): Honda T
  • Journal Title: J Mol Cell Cardiol 44 Pages: 915-926
  • Peer Reviewed
• [Journal Article] Differentiation of mouse and human ES cells into hepatic lineages. (2008)
  • Author(s): Shiraki N
  • Journal Title: Genes Cells 13 Pages: 731-746
  • Peer Reviewed
• [Journal Article] Specific pathogen free conditions prevent transthyretin amyloidos is in mouse models. (2008)
  • Author(s): Inoue S
  • Journal Title: Transgenic Res 17 Pages: 817-826
  • Peer Reviewed
• [Presentation] Onionin Aのマクロファージ活性化抑制作用 (2011)
  • Author(s): 藤原章雄、工藤梨乃、菰原義弘、野原稔弘、坂下直実、竹屋元裕
  • Organizer: 第100回日本病理学会総会第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] MMP9過剰産生による肺毛細血管基底膜破壊の結果、広範な肺線維症を合併した肺毛細血管腫症の剖検例 (2011)
  • Author(s): 坂下直実、本岡大社、菅沼雅人、藤原章雄、中川雄伸、一安秀範、竹屋元裕
  • Organizer: 第100回日本病理学会総会第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] ACAT1陽性後期エンドゾームの誘導によりC型Niemann-Pick病細胞のコレステロールエステル化能は正常化する (2011)
  • Author(s): 上川将史、坂下直実、雷小峰、竹屋元裕
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] コレステロールによるマクロファージの機能制御:ACAT1陽性特異オルガネラの同定から細胞内コレステロール代謝制御ファゴゾーム機能障害、C型ニーマンピック病治療戦略まで (2010)
  • Author(s): 坂下直実
  • Organizer: 第45回熊本大学生命科学研究部・化血研ジョイントセミナー
  • Place of Presentation: 熊本
  • Year and Date: 2010-07-07
• [Presentation] コレステロールによるマクロファージの機能制御:ACAT1陽性特異オルガネラの同定から細胞内コレステロール代謝制御、ファゴゾーム機能障害、C型ニーマンピック病治療戦略まで (2010)
  • Author(s): 坂下直実
  • Organizer: 第45回熊本大学生命科学研究部・化血研ジョイントセミナー
  • Place of Presentation: 熊本大学(熊本)
  • Year and Date: 2010-07-07
• [Presentation] 高脂血症病態のヒトマクロファージに出現するACAT1陽性エンドゾーム・ライソゾームの機能解析 (2010)
  • Author(s): 坂下直実、雷小峰、Catherine CY Chang、Ta-Yuan Chang、竹屋元裕
  • Organizer: 第50回日本リンパ網内系学会優秀ポスター演題口演
  • Place of Presentation: 新潟
• [Presentation] Translocation of ACAT1 from ER to Late Endosomal Associated Membranes in Cholesterol-rich Human Macrophage. (2010)
  • Author(s): XiaoFeng Lei, Naomi Sakashita, Yukio Fujiwara, Catherine CY Chang, Ta-Yuan Chang, Motohiro Takeya, Akira Miyazaki
  • Organizer: 18th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Kumamoto
• [Presentation] Corosolic acidのマクロファージ活性化抑制機構について (2010)
  • Author(s): 藤原章雄、菰原義弘、池田剛、坂下直実、竹屋元裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 子宮に発生したleiomyomatoid angiomatous neuroendocine tumor (LANT)の一例 (2010)
  • Author(s): 坂下直実、山田元大、中川雄伸、山崎秀樹、竹屋元裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 子宮に発生したleiomyomatoid angiomatous neuroendocine tumor(LANT)の一例 (2010)
  • Author(s): 坂下直実
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] Corosolic acidのマクロファージ活性化抑制機構について (2010)
  • Author(s): 藤原章雄
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] Translocation of ACAT1 from ER to Late Endosomal Associated Membranes in Cholesterol-rich Human Macrophage. (2010)
  • Author(s): Xiao Feng Lei
  • Organizer: 18^<th> International Symposium on Molecular Cell Biology of Macrophages 2010
  • Place of Presentation: パレアホール(熊本)
• [Presentation] 高脂血症病態のヒトマクロファージに出現するACAT1陽性エンドゾーム・ライソゾームの機能解析 (2010)
  • Author(s): 坂下直実
  • Organizer: 第50回日本リンパ網内系学会優秀ポスター演題口演
  • Place of Presentation: 朱鷺メッセ(新潟)
• [Presentation] Helicobacter cinaedi の血清診断法の確立と感染疫学 (2009)
  • Author(s): 岡本竜哉
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-12
• [Presentation] コレステロールによるマクロファージの機能制御:ACAT1陽性特異オルガネラの同定から細胞内コレステロール代謝制御、ファゴゾーム機能障害、C型ニーマンピック病治療戦略まで (2009)
  • Author(s): 坂下直実
  • Organizer: 第55回日本病理学会秋期特別総会日本病理学会学術研究賞受賞講演
  • Place of Presentation: 東京
• [Presentation] Translocation of acyl-coenzyme a : cholesterol acyltransferase 1 (ACAT1) from endoplasmic reticulum (ER) to late endosomes associated membranes in cholesterol-rich human macrophage. (2009)
  • Author(s): XiaoFeng Lei, Naomi Sakashita, Catherine CY Chang, Ta-Yuan Chang, Motohiro Takeya
  • Organizer: The 10th Japanese-Korean Lymphoreticular Workshop 2009
  • Place of Presentation: Fukushima
• [Presentation] Involvement of Macrophage Class A Scavenger Receptor (CD204) in Toll-like Receptor 4 Signal Transduction. (2009)
  • Author(s): Koji Ohnishi, Yoshihiro Komohara, Yukio Fujiwara, Emi Kiyota, XiaoFeng Lei, Naomi Sakashita, Kenichi Takemura, Motohiro Takeya.
  • Organizer: The 10th Japanese-Korean Lymphoreticular Workshop 2009
  • Place of Presentation: Fukushima
• [Presentation] Oleanolic acidのマクロファージ活性化制御作用について (2009)
  • Author(s): 藤原章雄、菰原義弘、池田剛、坂下直実、竹屋元裕
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 天然物由来AGEs生成阻害剤の探索(6) (2009)
  • Author(s): 吉冨万希子、藤原章雄、池田剛、永井竜児、坂下直実、竹屋元裕、塚本佐知子
  • Organizer: 日本生薬学会第56回年会
  • Place of Presentation: 京都
• [Presentation] コレステロールによるマクロファージの機能制御:ACAT1陽性特異オルガネラによるコレステロール代謝制御、異物貪食障害、C型ニーマンピック病治療戦略 (2009)
  • Author(s): 坂下直実
  • Organizer: 第50回日本細胞組織化学会
  • Place of Presentation: 大津
• [Presentation] Translocation of ACAT1 from ER to late endosomal associated membranes in cholesterol-rich human macrophages. (2009)
  • Author(s): XiaoFeng Lei, Naomi Sakashita, Yukio Fujiwara, Catherine CY Chang, Ta-Yuan Chang, Motohiro Takeya.
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 下関
• [Presentation] ランゲルハンス細胞組織球症に浸潤するM2マクロファージはIL-10の分泌を介して腫瘍細胞の増殖を抑制する (2009)
  • Author(s): 大西紘二、菰原義弘、坂下直実、猪山賢一、村山寿彦、竹屋元裕
  • Organizer: 第19回日本樹状細胞研究会
  • Place of Presentation: 兵庫
• [Presentation] CD204(class A scavenger receptor)はToll-like receptor 4のMyD88依存性及び非依存性シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二、菰原義弘、藤原章雄、坂下直実、清田恵美、竹村健一、竹屋元裕
  • Organizer: 第49回リンパ網内系学会総会
  • Place of Presentation: 兵庫
• [Presentation] Presence of ACAT1 on late endosome (LE) in cholesterol-rich macrophages : efficient cholesterol esterification on LE and possible therapeutic strategy for Niemann-Pick disease type C1. (2009)
  • Author(s): XiaoFeng Lei, Naomi Sakashita, Yukio Fujiwara, Catherine CY Chang, Ta-Yuan Chang, Motohiro Takeya.
  • Organizer: 17th International Sypmposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Kanazawa
• [Presentation] Translocation of acyl-CoA : cholesterol acyltransferase 1 enzyme (ACAT1) from endoplasmic reticulum to late endosomal associated membranes in cholesterol-rich human macrophages. (2009)
  • Author(s): XiaoFeng Lei, Naomi Sakashita Fujiwara, Yukio, Catherine CY Chang, Ta-Yuan Chang, Motohiro Takeya.
  • Organizer: International Symposium on Atherosclerosis 2009 (ISA2009)
  • Place of Presentation: Boston, USA
• [Presentation] クラスAスカベンジャー受容体(CD204)による破骨細胞分化制御の解析 (2009)
  • Author(s): 竹村健一、坂下直実、藤原章雄、菰原義弘、雷小峰、大西紘二、水田博志、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] ヒトマクロファージの活性化を制御する天然物由来化合物の探索 (2009)
  • Author(s): 藤原章雄、菰原義弘、池田剛、坂下直実、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 高脂血症病態のマクロファージはACAT1トランスロケーションによりファゴゾームの成熟遅延を引き起こす (2009)
  • Author(s): 坂下直実、雷小峰、キャサリーンCYチャン、タ・ユァン・チャン、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] エンドゾームへのACAT1トランスロケーションを用いたNiemann-Pick disease Type C(NPC)の治療戦略の探索 (2009)
  • Author(s): 雷小峰、坂下直実、藤原章雄、キャサリーンCYチャン、タ・ユァン・チャン、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 腫瘍内浸潤マクロファージにおけるCD204(class A scavenger receptor)発現の意義 (2009)
  • Author(s): 菰原義弘、竹村健一、坂下直実、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Helicobacter cinaediの血清診断法の確立と感染疫学 (2009)
  • Author(s): 岡本竜哉、Shahzada Khan、山部浩茂、藤井重元、澤智裕、河村好章、坂下直実、竹屋元裕、赤池孝章
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 腫瘍内浸潤マクロファージにおけるCD204(class A scavenger receptor)発現の意義 (2009)
  • Author(s): 菰原義弘
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場、京都(京都)
• [Presentation] エンドゾームへのACAT1トランスロケーションを用いた Niemann-Pick disease Type C(NPC)の治療戦略の探索 (2009)
  • Author(s): 雷小峰
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場、京都(京都)
• [Presentation] 高脂血症病態のマクロファージはACAT1トランスロケーションによりファゴゾームの成熟遅延を引き起こす (2009)
  • Author(s): 坂下直実
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場、京都(京都)
• [Presentation] ヒトマクロファージの活性化を制御する天然物由来化合物の探索 (2009)
  • Author(s): 藤原章雄
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場、京都(京都)
• [Presentation] クラスAスカベンジャー受容体(CD204)による破骨細胞分化制御の解析 (2009)
  • Author(s): 竹村健一
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場、京都(京都)
• [Presentation] Translocation of acyl-CoA : cholesterol acyltransferase 1 enzyme(ACAT1)from endoplasmic reticulum to late endosomal associated membranes in cholesterol-rich human macrophages (2009)
  • Author(s): 雷小峰
  • Organizer: International Symposium on Atherosclerosis 2009
  • Place of Presentation: Hynes Convention Center, Boston, USA
• [Presentation] Presence of ACAT1 on late endosome(LE)in cholesterol-rich macrophages : efficient cholesterol esterification on LE and possible therapeutic strategy for Niemann-Pick disease type C1 (2009)
  • Author(s): 雷小峰
  • Organizer: 17th International Sypmposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: KKR Hotel Kanazawa, Kanazawa, Japan
• [Presentation] Involvement of Macrophage Class A Scavenger Receptor(CD204)in Toll-like Receptor 4 Signal Transduction (2009)
  • Author(s): 大西紘二
  • Organizer: The 10th Japanese-Korean Lymphoreticular Workshop 2009
  • Place of Presentation: Fukushima View Hotel, Fukushima, Japan
• [Presentation] Translocation of acyl-coenzyme a : cholesterol acyltransferase 1(ACAT1)from endoplasmic reticulum(ER)to late endosomes associated membranes in cholesterol-rich human macrophage (2009)
  • Author(s): 雷小峰
  • Organizer: The 10th Japanese-Korean Lymphoreticular Workshop 2009
  • Place of Presentation: Fukushima View Hotel, Fukushima, Japan
• [Presentation] CD204(class A scavenger receptor)は Toll-like receptor 4のMyD88依存性及び非依存性シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二
  • Organizer: 第49回日本リンパ網内系学会総会
  • Place of Presentation: 淡路島夢舞台国際会議場, 淡路島(兵庫)
• [Presentation] ランゲルハンス細胞組織球症に浸潤するM2マクロファージはIL-10の分泌を介して腫瘍細胞の増殖を抑制する (2009)
  • Author(s): 大西紘二
  • Organizer: 第19回日本樹状細胞研究会
  • Place of Presentation: 淡路島夢舞台国際会議場, 淡路島(兵庫)
• [Presentation] Translocation of ACAT1 from ER to late endosomal associated membranes in cholesterol-rich human macrophages (2009)
  • Author(s): 雷小峰
  • Organizer: 第41回日本動脈硬化学会総会
  • Place of Presentation: 海峡メッセ下関, 下関(山口)
• [Presentation] 天然物由来AGEs生成阻害剤の探索(6) (2009)
  • Author(s): 吉冨万希子
  • Organizer: 日本生薬学会第56回年会
  • Place of Presentation: 京都薬科大学愛学館, 京都(京都)
• [Presentation] Oleanolic acid のマクロファージ活性化制御作用について (2009)
  • Author(s): 藤原章雄
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド, 神戸(兵庫)
• [Presentation] ACAT1陽性特異オルガネラの同定から細胞内コレステロール代謝制御、ファゴゾーム機能障害、C型ニーマンピック病治療戦略まで (2009)
  • Author(s): 坂下直実
  • Organizer: 第55回日本病理学会秋期特別総会(日本病理学会学術研究賞受賞講演)
  • Place of Presentation: 九段会館, 東京(東京都)
• [Presentation] Infiltrated macrophages suppress proliferation of Langerhans cells in Lange rhans cell hi stiocytosis (2008)
  • Author(s): Koji Ohnishi
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-05
• [Presentation] 腫瘍関連マクロファージにおけるCD204(class A scavenger receptor type I and II) 発現の意義 (2008)
  • Author(s): 菰原義弘
  • Organizer: 第48回日本リンパ網内系学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-13
• [Presentation] Langerhans cell histioc ytosis におけるマクロファージ系マーカーの発現解析と病態との関連性についての検討 (2008)
  • Author(s): 大西紘二
  • Organizer: 第48回日本リンパ網内系学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-13
• [Presentation] 肺腫瘍血栓性微小血管症(PTTM)の剖検解析 : 増殖内膜におけるセロトニン受容体の関与 (2008)
  • Author(s): 坂下直実
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-15
• [Presentation] 高脂血症病態のヒトマクロフアージに出現するACAT1陽性エンドブーム・ライソソームの解析 (2008)
  • Author(s): 雷 小峰
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-15
• [Presentation] 肝移植後に脳出血で死亡した髄膜アミロイドーシス合併家族性アミロイドポリニューロパチー(FAP)の剖検例 (2008)
  • Author(s): 大西紘二
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-15
• [Presentation] 肺病変(pulmonary thrombotic tumor microangiopathy : PTTM) (2008)
  • Author(s): 坂下直実
  • Organizer: 第301回九州・沖縄スライドコンファレンス
  • Place of Presentation: 鹿児島
  • Year and Date: 2008-01-26
• [Presentation] Infiltrated macrophages suppress proliferation of Langerhans cells in Langerhans cell histiocytosis. (2008)
  • Author(s): Koji Ohnishi, Yoshihiro Komohara, Naomi Sakashita, Motohiro Takeya
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe
• [Presentation] Langerhans cell histiocytosisにおけるマクロファージ系マーカーの発現解析と病態との関連性についての検討 (2008)
  • Author(s): 大西紘二、菰原義弘、坂下直実、竹屋元裕
  • Organizer: 第48回日本リンパ網内系学会
  • Place of Presentation: 札幌
• [Presentation] 腫瘍関連マクロファージにおけるCD204 (class A scavenger receptor type I and II)発現の意義 (2008)
  • Author(s): 菰原義弘、竹村健一、坂下直実、竹屋元裕
  • Organizer: 第48回日本リンパ網内系学会
  • Place of Presentation: 札幌
• [Presentation] 肝移植後に脳出血で死亡した髄膜アミロイドーシス合併家族性アミロイドポリニューロパチー(FAP)の剖検例 (2008)
  • Author(s): 大西紘二、坂下直実、山下太郎、植田光晴、内野誠、安東由喜雄、竹屋元裕
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 石川
• [Presentation] 高脂血症病態のヒトマクロファージに出現するACAT1陽性エンドゾーム・ライソゾームの解析 (2008)
  • Author(s): 雷小峰、坂下直実、Catherine CY Chang、Ta-Yuan Chang、竹屋元裕
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 石川
• [Presentation] 肺腫瘍血栓性微小血管症(PTTM)の剖検解析:殖内膜におけるセロトニン受容体の関与 (2008)
  • Author(s): 坂下直実、横瀬千美、藤井一彦、松本充博、竹屋元裕
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 石川
• [Presentation] Acyl-CoA : cholesterol acyltransferase (ACAT)が関与する循環器疾患 (2008)
  • Author(s): 坂下直実
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html