| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
I examined whether a series of ischemia-reperfusion condition could act on normal epithelial cells as an endogenous carcinogenic factor. I used three epithelial cell lines to examine whether those cell lines could be converted into tumorigenic ones after cultivation in a series of hypoxia-reoxygenation condition, i.e., between the incubators kept at 1% and 20% O_2 concentrations. The cell lines were sporadically converted into tumorigenic ones in nude mice after serial long passages. I also examined whether a series of ischemia-reperfusion condition could be carcinogenic by using mouse kidney ; so far I have not detected any tumors in the ischemia-reperfusion organ. I need to examine possible conversion using another organ.
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