Molecular mechanisms maintaining leukemic stem cells by forkhead transcription factor Foxo
| Project/Area Number |
20590394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKA Kazuhito Kanazawa University, がん研究所, 准教授 (70372688)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん幹細胞 / 慢性骨髄性白血病 / 抗がん剤抵抗性 / FOXO / TGF-・阻害剤 / チロシンキナーゼ阻害剤抵抗性 / TGF-β阻害剤 / 白血病幹細胞 / フォークヘッド転写因子 / がん / 白血病 |
|---|
| Research Abstract |
In this study, we demonstrated a critical role for the TGF-β-FOXO pathway in maintenance and imatinib resistance of leukemia-initiating cells (LICs) in chronic myeloid leukemia (CML) which are responsible for recurrence of disease. TGF-β inhibitor in combination with imatinib treatment led to efficient depletion of LICs in vivo.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Suppression of glioma-initiating cell self-renewal by NKX2.2.2011
Author(s)
Muraguchi T., Tanaka S., Yamada D., Tamase A., Nakada M., Nakamura H., Hoshii T., Ooshio T., Tadokoro Y., Naka K., Ino Y., Todo T., Kuratsu J., Saya H., Hamada J., Hirao A.
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Journal Title
Cancer Res. 71(3)
Pages: 1135-1145
Related Report
Peer Reviewed
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