| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Adrenomedullin (AM) is a vasoactive peptide which is secreted by many tissues, and plays an important role in anti-inflammation, vasodilation and angiogenesis. AM receptor is composed of two proteins ; calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP) 2 or 3. The space- and time-dependent use of RAMPs became suggested to be important for unique AM function in several organs. However, the mechanisms and roles of RAMPs in the AM-RAMPs system remain obscure. In this study, we investigated the pathophysiological role of RAMP2/3 using vascular endothelial cell-specific and cardiac cell-specific RAMP2 KO mice because of the embryonic lethal of RAMP2KO at mid-gestation, and RAMP3KO including RAMP2/RAMP3 and RAMP3-Tg mice. We have found that (1) RAMP2 is essential for vascular and cardiac homeostasis based on the vaso- and organ-protective effects of AM (2) RAMP3 is involved in inflammatory response.
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