A study of the participation of viral anti-apoptotic factor in the pathogenesis of developmental brain disorders induced by viral infection
| Project/Area Number |
20590396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KOSUGI Isao Hamamatsu University School of Medicine, 医学部, 准教授 (10252173)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Hideya 浜松医科大学, 医学部, 助教 (90397381)
ARAI Yoshifumi 浜松医科大学, 医学部, 助教 (30381784)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 発生病理 / ウイルス感染症 / サイトメガロウイルス / 神経細胞 / 脳発達障害 / 神経細胞死 / ネクローシス / 興奮毒性細胞死 / アポトーシス |
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| Research Abstract |
Virus-derived anti-apoptotic protein not only blocks cell death, but also establishes persistent infection, resulting in functional disturbances and malignant transformation of host cells. Cytomegalovirus (CMV) persistently infects developing cerebral neurons, and is the leading viral cause of developmental brain disorders in humans. In this study, we have investigated the impact of M45 protein, a representative of CMV-derived anti-apoptotic proteins, on the development of cerebral neurons. Wild type CMV inhibited the arborization of dendrites in developing neurons, however, M45-deleted CMV did not. This result indicates that M45 protein not only blocks cell death, but also disturbs neuronal development.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] In vivo imaging assay for the convenient evaluation of antiviral compounds against cytomegalovirus in mice.2010
Author(s)
Yamada, S., Kosugi I., Katano, H, Fukui, Y., Kawasaki, H., Arai, Y., Kcrane, I., Inoue, N.
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Journal Title
Antiviral Res 88
Pages: 45-52
Related Report
Peer Reviewed
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[Journal Article] In vivo imaging assay for the convenient evaluation of antiviral compounds against cytomegalovirus in mice2010
Author(s)
Yamada, S., Kosugi, I., Katano, H., Fukui, Y., Kawasaki, H., Arai, Y., Kurane, I., Inoue, N
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Journal Title
Antiviral Res
Volume: 88
Pages: 45-52
Related Report
Peer Reviewed
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[Journal Article] Aggressive progression of breast cancer with microscopic pulmonary emboli possessing a stem cell-like phenotype independent of its origin2010
Author(s)
Kawasaki, H., Ogura, H., Arai, Y., Baba, S., Kosugi, I., et al.
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Journal Title
Pathol Int
Volume: 60
Pages: 228-234
NAID
Related Report
Peer Reviewed
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[Presentation] In vivo imaging assay for the convenient evaluation of antiviral compounds against cytomegalovirus in mice2010
Author(s)
Yamada, S., Kosugi, L, Katano, H., Fukui, Y., Kawasaki, H., Arai, Y, Kurane, I., N.Inoue
Organizer
Congenital Cytomegalovirus Conference
Place of Presentation
Paris, France
Year and Date
2010-09-15
Related Report
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[Presentation] In vivo imaging assay for the convenient evaluation of antiviral compounds against cytomegalovirus in mice2010
Author(s)
Yamada, S., Kosugi I., Katano, H., Fukui, Y. , Kawasaki, H., Arai, Y., Kurane, I., N.Inoue.
Organizer
2010 Congenital Cytomegalovirus Conference
Place of Presentation
France
Related Report
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