Moleular Basis for HGF-mediated Self-defense System During sepsis
| Project/Area Number |
20590398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
MIZUNO Shinya Osaka University, 医学系研究科, 助教 (10219644)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Toshikazu 大阪大学, 先端科学イノベーションセンター, 特任教授 (00049397)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HGF / c-Met / 多臓器不全 / 敗血症 / 炎症性サイトカイン / マクロファージ / 肝細胞増殖因子 / 腎傷害 / 蛋白尿 / ポドサイト / 炎症性サイトカイ / スリット蛋白 / ネフリン / 高サイトカイン血症 / 分子機構 / 血栓形成 / 多臟器不全 / HO-1 |
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| Research Abstract |
We demonstrated that direct effects of HGF on macrophages during leads to inhibition of the NF-?b activation and subsequent transcription of pro-inflammatory cytokines. Furthermore, we found, using a mouse model of sepsis, that HGF-mediated up-regulation of hemeoxygenese-1 is required for HGF to inhibit the onset of septic acute renal failure, lung injury and hepatitis. Based on the present data, we conclude that enhancement of the HGF-hemeoxygenase-1 pathway in macrophages can be a reasonable strategy to improve the sepsis-related pathological conditions.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Gelfand EW and Kanehiro A : Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice.2008
Author(s)
Ito W, Tanimoto M, Ono K, Mizuno S, Yoshida A, Koga H, Fuchimoto Y, Kondo N, Tanimoto Y, Kiura K, Matsumoto K, Kataoka M, Nakamura T.
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Journal Title
Int Arch Allergy Immunol 145
Pages: 324-339
Related Report
Peer Reviewed
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