Study on mechanisms of autoantibody production in the pathophysiology of lysosomal storage disorders
| Project/Area Number |
20590407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
YAMANAKA Shoji Yokohama City University, 附属病院, 准教授 (80264604)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Akira 横浜市立大学, 医学研究科, 客員研究員 (20381585)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ライソゾーム病 / 自己抗体 / 胸腺 / サイトカイン・ケモカイン |
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| Research Abstract |
In this study we focused on thymic event from the point of morphology, thymic subpopulation, and gene expression to see the autoimmune mechanisms happening in Sandhoff disease (SD) mice. Thymus from SD mice greater than 15weeks of age showed marked decrease in the percentage of immature T cells and significantly increased CD4+ T cells. During the involution, apoptotic thymic cells and IgG deposition to T cells were increased. CXCL13, one of these genes, was expressed specifically in the thymus, and B1 cells were increased in the thymus. These results suggest that in SD mice it may convert the usually poorly immunogenic thymus into an organ prone to induce autoimmunity, including chemotaxis of B1 cells toward CXCL13.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Thymic alterations in GM2 gangliosidoses model mouse.2010
Author(s)
Kanzaki S, Yamaguchi A, Yamaguchi K, Kojima Y, Koumitsu N, Nagashima Y, Nagahama K, Ehara M, Hirayasu Y, Ryo A, Aoki I, Yamanaka S
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Journal Title
Related Report
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