• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of target genes for the language-related FOXP2 transcription factor

Research Project

Project/Area Number 20590409
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

OIKAWA Tsuneyuki  Health Sciences University of Hokkaido, 心理科学部, 教授 (80150241)

Co-Investigator(Kenkyū-buntansha) OHTA Tohru  北海道医療大学, 個体差健康科学研究所, 准教授 (10223835)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsFOXP2 / 転写因子 / 言語 / 脳神経
Research Abstract

Recent findings of the FOXP2 gene provide a new research field combined linguistic studies and molecular genetics. Mutations of the FOXP2 gene, a FOX family transcription factor, have been reported in families of specific language impairment in human. Two amino acid changes occurred in the FOXP2 genes during evolution from primate lineages to human being. We tried to identify the target genes of the human and chimpanzee FOXP2 with microarray techniques. We adapted the flip-in recombinase and Tet ON/OFF systems to minimize transfection artifacts. Significant expression changes were found in 1,671 genes, in which 641 genes were up-regulated and 1,030 genes were down-regulated comparing with the expression profiles of human Tet ON and Tet OFF conditions. Significant expression changes were found in 1,562 genes, in which 794 genes were up-regulated and 768 genes were down-regulated, comparing with the expression profiles of chimpanzee Tet ON and Tet OFF conditions. Furthermore, significant expression changes were found in 2,836 genes, 1,433genes were up-regulated and 1,403 genes were down regulated, comparing with the expression profiles of human Tet ON and chimpanzee Tet ON conditions. Our results showed some target genes are common but some are different between the human and chimpanzee FOXP2 transcription factors. Comparing of our data in Tet ON/OFF system with previous data obtained from a microassay analysis and a ChIP-on-chip analysis, it is suggested that seven genes (genes names are not shown till acceptance of our paper) are clearly targets of the human FOXP2 genes. More detail analyses of these affected genes could contribute elucidation for the mechanism of human brain development for language acquisition and genetic diagnosis of human language disorders.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Down-regulation of ABCC11 protein (MRP8) in human breast cancer.2011

    • Author(s)
      Sosonkina N, Nakashima M, Ohta T, Niikawa N, Starenki D.
    • Journal Title

      Exp Oncol. 33(1)

      Pages: 42-46

    • Related Report
      2010 Final Research Report
  • [Journal Article] Down-regulation of ABCC11 protein (MRP8) in human breast cancer2011

    • Author(s)
      Sosonkina N, et al.
    • Journal Title

      Exp Oncol

      Volume: 33(1) Pages: 42-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.2010

    • Author(s)
      Ng SB, Bigham AW, Buckingham KJ, Hannibal MC, McMillin MJ, Gildersleeve HI, Beck AE, Tabor HK, Cooper GM, Mefford HC, Lee C, Turner EH, Smith JD, Rieder MJ, Yoshiura K, Matsumoto N, Ohta T, Niikawa N, Nickerson DA, Bamshad MJ, Shendure J.
    • Journal Title

      Nat.Genet. 42(9)

      Pages: 790-793

    • Related Report
      2010 Final Research Report
  • [Journal Article] Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome2010

    • Author(s)
      Ng SB, et al.
    • Journal Title

      Nat.Genet.

      Volume: 42(9) Pages: 790-793

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Super Science High School (SSH) Consortium Japanese map of the earwax gene frequency : a nation-wide collaborative study by Super Science High School (SSH) Consortium.2009

    • Author(s)
      S Sakai, K Imai, T Ogawa, H Iwaoka, M Ishii, S Komori, T Yoshida, H Jumonji, K Iizumi, H Ohshima, T Maeda, A Kanno, K Takahashi, H Kubota, Y Inoue, Y Takahashi, H Onoda, R Uchiyama, M Matsuda, T Akazawa, N Kawamura, T Odagiri, Y Watanabe, Y Matsumoto, S Shinoda, M Terada, M Matsuoka, C Ueno, E Ozaki, S Takaya, T Takeyama, T Hujita, K Kawakatsu, J Takemura, H Maekawa, T Doei, S Ihara, Y Sakaguchi, Y Hirota, A Shindo, H Araki, J Miura, T Morita, T Fujiwara, H Akiyama, S Itome, Y Tanaka, K Nakagawa, S Okamoto, S Yamamoto, T Aoyagi, T Noda, Inoue, I Hirota, K Tanaka, T Nagashima, I Koga, K Watanabe, H Kusadome, H Otsuka, T Takayama, H Miwa, A Hamakawa, K China, N Niikawa, T Ohta, D Starenki, K Umehara, K Yamada, Y Shimada, H Nagasawa, T Minato, T Ogino, K Yoshiura, N Miwa, M Nomura, H Kuniba, Y Noguchi, S Ono, M Tsuda, M Nakashima, T Kikuchi, D Satoh, T Kishino, S Kondo, A Kinoshita
    • Journal Title

      J Hum Genet 54

      Pages: 499-503

    • Related Report
      2010 Final Research Report
  • [Journal Article] Developmentally dynamic changes of DNA methylation in the mouse Snurf/Snrpn gene.2009

    • Author(s)
      Miyazaki K, Mapendano CK, Fuchigami Y, Kondo S, Ohta T, Kinoshita A, Tsukamoto K, Yoshiura K, Niikawa N, Kishino T
    • Journal Title

      Gene 432

      Pages: 97-101

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新川詔夫 DNAメチル化と遺伝子発現制御のしくみを探る2009

    • Author(s)
      太田亨
    • Journal Title

      Biophilia 5(3)

      Pages: 11-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Japanese map of the earwax gene frequency : a nationwide collaborative study by Super Science High School Consortium.2009

    • Author(s)
      Super Science High School Consortium
    • Journal Title

      J Hum Genet. 54

      Pages: 499-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmentally dynamic changes of DNA methylation in the mouse Snurf/Snrpn gene.2009

    • Author(s)
      Miyazaki K, Ohta T., et al.
    • Journal Title

      Gene. 432

      Pages: 97-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical and functional interactions between hematopoietc cell-specific ETS transcription factors and homeodoman proteins.2008

    • Author(s)
      Yamada T., et al
    • Journal Title

      Leukemia research 33(3)

      Pages: 483-489

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人におけるヒト耳垢遺伝子ABCC11のΔ27アリルの新たな見解2010

    • Author(s)
      松田律史, 山田愛子, 小野佑輔, , スタレンキディミトロ, ソソンキナナディア, 吉浦孝一郎, 太田亨, 新川詔夫
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド,神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] ホールエクソンキャプチャーによる歌舞伎メーキャップ症候群の解析2010

    • Author(s)
      要匡, 塚原正俊, 柳久美子, 藤森一浩, 喜久里育也, 照屋盛実, 今田有美, 鼠尾まい子, 矢野修一, 佐藤友紀, 三輪有希乃, 平野隆, 吉浦孝一郎, 太田亨, 新川詔夫, 成富研二
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド,神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery of a gene for Kabuki syndrome by exome sequencing and genotype-phenotype relationship in 110 cases.2010

    • Author(s)
      M.J. Bamshad. M.C. Hannibal, K.J. Buckingham, A.E. Beck, S.B. Ng, M. McMillin, H. Gildersleeve, A.W. Bigham, H.K. Tabor, K.Yoshiura, T. Matsumot, N. Matsumoto, H. Tonoki, K.Naritomi, T. Kaname, T. Nagai, H. Ohashi, K. Kurosawa, J. Hou, T.Ohta, C.A. Morris, J.E. Ming, T.H. Shikh, S. Banka, G. Black, J. Clayton-Smith, E.H. Zackai, D. Donnai, N.Niikawa, D.A. Nickerson, J. Shendure.
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人におけるヒト耳垢遺伝子ABCC11のΔ27アリル頻度2010

    • Author(s)
      山田愛子, 堀佑輔, 小野佑輔, 松田律史, ストランキーディマ, ソソンキナナディア, 吉浦孝一郎, 新川詔夫, 太田亨
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮
    • Related Report
      2010 Final Research Report
  • [Presentation] 歌舞伎メーキャップ症候群のエクソーム解析2010

    • Author(s)
      要匡, 塚原正俊, 柳久美子, 藤森一浩, 喜久里育也, 照屋盛実, 今田有美, 鼠尾まい子, 矢野修一, 佐藤友紀, 三輪有希乃, 平野隆, 吉浦孝一郎, 太田亨, 新川詔夫, 成富研二
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮
    • Related Report
      2010 Final Research Report
  • [Presentation] ABCC11 expression and 538G/A poly-morphism in human breast cancer.2010

    • Author(s)
      Sosonkina Nadiya, Starenki Dmytro, 太田亨, 吉浦孝一郎, 新川詔夫
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮
    • Related Report
      2010 Final Research Report
  • [Presentation] Frequency of 27-bp deletion mutation, another earwax determinant, in ABCC11 among the Japanese population.2010

    • Author(s)
      A.Yamada, Y.Hori, Y.Ono, N.Matsuda, D. Starenki, N. Sosonkina, K.Yoshiura, T.Ohta, N.Niikawa
    • Organizer
      The American Society of Human Genetics, 59th Annual Meeting
    • Place of Presentation
      Washigton D.C., Baltimore
    • Related Report
      2010 Final Research Report
  • [Presentation] Frequency of 27-bp deletion mutation, allother earwax determinant, in ABCC11 among the Japanese population2010

    • Author(s)
      A.Yamada, et al.
    • Organizer
      The American Society of Human Genetics, 59th
    • Place of Presentation
      Washington D.C., Baltimore, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人におけるヒト耳垢遺伝子ABCC11のΔ27アリルの新たな見解2010

    • Author(s)
      松田律史
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド,神戸(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホールエクソンキャプチャーによる歌舞伎メーキャップ症候群の解析2010

    • Author(s)
      要匡
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド,神戸(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery of a gene for Kabuki syndrome by exome sequencing and genotype-phenotype relationship in 110 cases.2010

    • Author(s)
      M.J.Bamshad, et al.
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮(埼玉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人におけるヒト耳垢遺伝子ABCC11のΔ27アリル頻度2010

    • Author(s)
      山田愛子
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮(埼玉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歌舞伎メーキャップ症候群のエクソーム解析2010

    • Author(s)
      要匡
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮(埼玉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ABCC11 expression and 538G/A polymorphism in human breast cancer.2010

    • Author(s)
      Sosonkina Nadiya
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮ソニックシティー,大宮(埼玉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA array-based copy number analysis in chorionic cillus samples (CVS) of spontaneous abortions with normal karyotypes.2009

    • Author(s)
      Yamada T, Ohra T, Hosoki K, Shimada S, Morikawa M, Yamada T, Yoshiura K, Minakami H, Niikawa N
    • Organizer
      The American Society of Human Genetics, 59th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2010 Final Research Report
  • [Book] 症候群ハンドブック2011

    • Author(s)
      井村裕夫(総編集)
    • Total Pages
      757
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi