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Identification of downstream regulatory factor in RET signaling pathway and its application to cancer treatment

Research Project

Project/Area Number 20590412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionChubu University

Principal Investigator

ICHIHARA Masatoshi  Chubu University, 生命健康科学部, 教授 (00314013)

Co-Investigator(Kenkyū-buntansha) IWAMOTO Takashi  中部大学, 生命健康科学部, 教授 (60223426)
QIAO Shanlou  中部大学, 生命健康科学部, 准教授 (00343658)
MURAKUMO Yoshiki  名古屋大学, 大学院・医学系研究科, 准教授 (40324438)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsRET / チロシンキナーゼ / アイソフォーム / DNAマイクロアレイ / isoform / LC/MS / LC / MS
Research Abstract

Ret tyrosine kinase (RET) plays critical roles in embryonic development as well as oncogenesis. RET is mainly expressed as two isoforms, RET51 and RET9, which have different C-terminal ends generated through alternative splicing , whereas previous studies show that RET9 is indispensable for nephrogenesis and enteric neurogenesis. We found remarkable increase of tyrosine- phosphorylated proteins in the cells after inducible expression of RET9 in MEF3T3 cells. We demonstrated that 261 genes were differentially expressed under inducible expression of either RET51 or RET9 by gene expression profiling. Ingenuity pathway analysis revealed that gene expression-related genes, including transcription factors, were enriched in these differentially expressed genes. Next we tried to identify differentially binding protein to RET between RET51 and RET9 using LC/MS, but we failed to find such candidate proteins, accounting for different function between RET51 and RET9.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (98 results)

All 2011 2010 2009 2008

All Journal Article (47 results) (of which Peer Reviewed: 47 results) Presentation (50 results) Book (1 results)

  • [Journal Article] Assessment of factors influencing FDG uptake in non-small cell lung cancer on PET/CT by investigating histological differences in expression of glucose transporters 1 and 3 and tumour size.2011

    • Author(s)
      Suzawa N, Ito M, Qiao S, Uchida K, Takao M, Yamada T, Takeda K, Murashima S
    • Journal Title

      Lung Cancer. 72

      Pages: 191-198

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] beta-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells.2011

    • Author(s)
      Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S
    • Journal Title

      Mol Cell Neurosci. 46

      Pages: 770-780

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of factors influencing FDG uptake in non-small cell lung cancer on PET/CT by investigating histological differences in expression of glucose transporters 1 and 3 and tumour size2011

    • Author(s)
      Suzawa N
    • Journal Title

      Lung Cancer

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice2011

    • Author(s)
      Miyamoto R
    • Journal Title

      Dev Biol

      Volume: 349 Pages: 160-168

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective Role of Gipie, a Girdin Family Protein, in Endoplasmic Reticulum Stress Responses in Endothelial Cells2011

    • Author(s)
      Matsushita E
    • Journal Title

      Mol Biol Cell

      Volume: 22 Pages: 736-747

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney2011

    • Author(s)
      Saito S
    • Journal Title

      Hum Pathol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.2010

    • Author(s)
      Sekimoto T, Oda T, Pozo FM, Murakumo Y, Masutani C, Hanaoka F, Yamashita T
    • Journal Title

      Mol Cell. 37

      Pages: 79-89

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells : the role of COUP-TFI.2010

    • Author(s)
      Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, Ichihara M, Takagi A, Kojima T, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Suzuki M, Banno Y, Nozawa Y, Murate T
    • Journal Title

      J Neurochem. 112

      Pages: 511-520

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] REGgamma modulates p53 activity by regulating its cellular localization.2010

    • Author(s)
      Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X
    • Journal Title

      J Cell Sci. 123

      Pages: 4076-4084

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.2010

    • Author(s)
      Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M
    • Journal Title

      Cancer Sci. 101

      Pages: 1147-1155

    • NAID

      10026592015

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.2010

    • Author(s)
      Hagiwara S, Murakumo Y, Mii S, Shigetomi T, Yamamoto N, Furue H, Ueda M, Takahashi M
    • Journal Title

      Oncogene. 29

      Pages: 2181-2191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells : the role of COUP-TFI2010

    • Author(s)
      Murakami M
    • Journal Title

      J Neurochem

      Volume: 112 Pages: 511-520

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Processing of CD109 by furin and its role in the regulation of TGF-beta signaling2010

    • Author(s)
      Hagiwara S
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2181-2191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression2010

    • Author(s)
      Hagikura M
    • Journal Title

      Pathol int

      Volume: 60 Pages: 735-743

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells : the role of COUP-TFI2010

    • Author(s)
      Murakami M
    • Journal Title

      J Neurochem 112

      Pages: 511-520

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells2010

    • Author(s)
      Sekimoto T
    • Journal Title

      Mol Cell 37

      Pages: 79-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of microRNA processing by p53.2009

    • Author(s)
      Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K
    • Journal Title

      Nature. 460

      Pages: 529-533

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis.2009

    • Author(s)
      Qiao S, Iwashita T, Ichihara M, Murakumo Y, Yamaguchi A, Isogai M, Sakata K, Takahashi M
    • Journal Title

      Clin Neuropathol. 28

      Pages: 105-112

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice.2009

    • Author(s)
      Mirza R, Qiao S, Murata Y, Seo H
    • Journal Title

      Am J Dermatopathol. 31

      Pages: 446-452

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.2009

    • Author(s)
      Kato T, Shimono Y, Hasegawa M, Jijiwa M, Enomoto A, Asai N, Murakumo Y, Takahashi M
    • Journal Title

      Cancer Res. 69

      Pages: 3597-3604

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.2009

    • Author(s)
      Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y
    • Journal Title

      Biochem Biophys Res Commun. 389

      Pages: 651-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells.2009

    • Author(s)
      Hasegawa H, Senga T, Ito S, Iwamoto T, Hamaguchi M
    • Journal Title

      Exp Cell Res. 315

      Pages: 1384-1392

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.2009

    • Author(s)
      Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K
    • Journal Title

      Neurosci Lett. 453

      Pages: 81-85

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009

    • Author(s)
      Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M
    • Journal Title

      Neuron. 63

      Pages: 774-787

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells2009

    • Author(s)
      Itoh T
    • Journal Title

      Biochem Biophys Res Commun 389

      Pages: 651-656

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice2009

    • Author(s)
      Mirza R
    • Journal Title

      Am J Dermatopathol 31

      Pages: 446-452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron-dependent oxidative inactivation with affinity cleavage of pyruvate kinase2009

    • Author(s)
      Murakami K
    • Journal Title

      Biol Trace Elem Res 130

      Pages: 31-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of microRNA processing by p532009

    • Author(s)
      Suzuki HI
    • Journal Title

      Nature 23

      Pages: 529-533

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress2009

    • Author(s)
      Kato T
    • Journal Title

      Cancer Res 69

      Pages: 3597-3604

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Ret finger protein correlates with outcomes in endometrial cancer2009

    • Author(s)
      Tsukamoto H
    • Journal Title

      Cancer Sci 100

      Pages: 1895-1901

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus2009

    • Author(s)
      Enomoto A
    • Journal Title

      Neuron 63

      Pages: 774-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-inducednigrostriatal degeneration in a rat model of Parkinson's disease2009

    • Author(s)
      Fu Y
    • Journal Title

      Neurosci Lett 453

      Pages: 81-85

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression og glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis2009

    • Author(s)
      Qiao S
    • Journal Title

      Clin Neuropathol 28

      Pages: 105-112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells2009

    • Author(s)
      Hasegawa H
    • Journal Title

      Exp Cell Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron-Dependent Oxidative Inactivation with Affinity Cleavage of Pyruvate Kinase2009

    • Author(s)
      Murakami K
    • Journal Title

      Biol Trace Elem Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.2008

    • Author(s)
      Tsutsui M, Hasegawa H, Adachi K, Miyata M, Huang P, Ishiguro N, Hamaguchi M, Iwamoto T
    • Journal Title

      Biochem Biophys Res Commun. 372

      Pages: 856-861

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.2008

    • Author(s)
      Suzuki C, Murakumo Y, Kawase Y, Sato T, Morinaga T, Fukuda N, Enomoto A, Ichihara M, Takahashi M
    • Journal Title

      Biochem Biophys Res Commun. 366

      Pages: 226-232

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice.2008

    • Author(s)
      Hasegawa T, Enomoto A, Kato T, Kawai K, Miyamoto R, Jijiwa M, Ichihara M, Ishida M, Asai N, Murakumo Y, Ohara K, Niwa Y, Goto H, Takahashi M
    • Journal Title

      Oncogene. 27

      Pages: 5684-5695

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice2008

    • Author(s)
      Hasegawa T
    • Journal Title

      Oncogene 27

      Pages: 5684-5695

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-12008

    • Author(s)
      Suzuki C
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 226-232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP2008

    • Author(s)
      Tsutsui M
    • Journal Title

      Biochem Biophys Res Commun 372

      Pages: 856-861

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na(+)-independent Mg(2+)transport sensitive to 2-aminoethoxydiphenyl borate (2-APB)in vascular smooth muscle cells : involvement of TRPM-like channels2008

    • Author(s)
      Hamaguchi Y
    • Journal Title

      J Cell Mol Med 12

      Pages: 962-974

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of NADPH oxidase 1 in tumour colon epithelial cells2008

    • Author(s)
      Nisimoto Y
    • Journal Title

      Biochem J 15

      Pages: 57-65

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An actin-binding protein Girdin regulates the motility of breast cancer cells.2008

    • Author(s)
      Jiang P
    • Journal Title

      Cancer Res 68

      Pages: 1310-1318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.2008

    • Author(s)
      Jijiwa M
    • Journal Title

      Genes Cells 13

      Pages: 365-374

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD109 expression in basal-like breast carcinoma.2008

    • Author(s)
      Hasegawa M
    • Journal Title

      Pathol Int 58

      Pages: 288-294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity.2008

    • Author(s)
      Hagiwara S
    • Journal Title

      Cancer Sci 99

      Pages: 1916-1923

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分子状水素投与による肝保護効果の検討2011

    • Author(s)
      祖父江沙矢加
    • Organizer
      分子状水素医学シンポジウム
    • Place of Presentation
      名古屋大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Altered brain microRNA biogenesis affects neural stem cell proliferation in mouse hippocampal dentate gyrus2010

    • Author(s)
      Ouchi Y
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場7(兵庫県)
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水素水投与後の血中水素濃度動態の検討2010

    • Author(s)
      山井一晃、祖父江沙矢加、大桑哲男、市原正智
    • Organizer
      第2回水素研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 水素水投与後の血中水素濃度動態の検討2010

    • Author(s)
      山井一晃
    • Organizer
      第2回水素研究会学術集会
    • Place of Presentation
      アルカディア市ヶ谷(東京)
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 水素水投与後の血中・臓器濃度と肝臓内酸化ストレス軽減効果の検討2010

    • Author(s)
      市原正智、祖父江沙矢加、山井一晃、大桑哲男
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Cereulide毒素による肝障害に対する分子状水素の肝保護効果の検討2010

    • Author(s)
      祖父江沙矢加、岡本陽、安形則雄、市原正智
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Zebrafishを用いたRNA結合タンパク質Lin28の機能解析2010

    • Author(s)
      山本純矢、大内靖夫、岩本隆司
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 腸管上皮細胞におけるRNA結合分子Lin28の機能解析2010

    • Author(s)
      大内靖夫、朝枝祐太、水野麻衣、高岡祐司、岩本隆司
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of CD109 in the regulation of TGF-beta signaling.2010

    • Author(s)
      Yoshiki Murakumo, Sumitaka Hagiwara, Shinji Mii, Minako Hagikura, Masahide Takahashi
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] CD109-LacZノックインマウスにおける皮膚表現型の解析2010

    • Author(s)
      三井伸二、村雲芳樹、浅井直也、高橋雅英
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子TFII-IとhREV7との相互作用とその生理学的意義の解析2010

    • Author(s)
      村雲芳樹、高橋雅英
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 分子状水素によるI型アレルギー抑制機構の解明2010

    • Author(s)
      伊藤智広、藤田泰典、伊藤美佳子、増田章男、市原正智、小島俊男、野澤義則、大野欽司、伊藤雅史
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト神経膠芽腫細胞におけるCD109発現の生物学的意義の検討2010

    • Author(s)
      村雲芳樹、高橋雅英
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] CD109 expression promotes cell activity and enhances EGF signaling in human glioblastoma cells.2010

    • Author(s)
      Murakumo Y, Zhang JM, Takahashi M
    • Organizer
      101th Annual Meeting, American association for Cancer Research.
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 分子状水素によるI型アレルギー抑制の分子機構2010

    • Author(s)
      伊藤智広、藤田泰典、伊藤美佳子、増田章男、市原正智、小島俊男、野澤義則、大野欽司、伊藤雅史
    • Organizer
      第130回日本薬学会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] 分子状水素によるI型アレルギー抑制機構の解明2010

    • Author(s)
      伊藤智広
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水素水投与後の血中・臓器濃度と肝臓内酸化ストレス軽減効果の検討2010

    • Author(s)
      市原正智
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cereulide毒素による肝障害に対する分子状水素の肝保護効果の検討2010

    • Author(s)
      祖父江沙矢加
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Zebrafishを用いたRNA結合タンパク質Lin28の機能解析2010

    • Author(s)
      山本純矢
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸管上皮細胞におけるRNA結合分子Lin28の機能解析2010

    • Author(s)
      大内靖夫
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] エボジアミンの抗糖尿病作用における膵島β細胞UCP2の役割2010

    • Author(s)
      喬善楼
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD109 expression promotes cell activity and enhances EGF signaling in human glioblastoma cells2010

    • Author(s)
      Murakumo Y
    • Organizer
      101th Annual Meeting, American association for Cancer Research
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD109ノックアウトマウスにおける毛周期の変化2010

    • Author(s)
      三井伸二
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト神経膠芽腫細胞におけるCD109発現の生物学的意義の検討2010

    • Author(s)
      村雲芳樹
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱癌におけるCD109発現の臨床病理学的特徴との関連性の検討2010

    • Author(s)
      萩倉美奈子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD109-LacZノックインマウスにおける皮膚表現型の解析2010

    • Author(s)
      三井伸二
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場 他
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写因子TFII-IとhREV7との相互作用とその生理学的意義の解析2010

    • Author(s)
      村雲芳樹
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場 他
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of CD109 in the regulation of TGF-β signaling2010

    • Author(s)
      村雲芳樹
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] GPIアンカー型膜蛋白CD109のヒト腫瘍における発現とその生物学的意義2009

    • Author(s)
      村雲芳樹
    • Organizer
      名古屋大学グローバルCOEプログラム「機能分子医学への神経疾患・腫瘍の融合拠点」第2回国内シンポジウム
    • Place of Presentation
      名古屋大学大学院医学系研究科研究棟1号館(名古屋)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト神経膠芽腫細胞におけるCD109発現の生物学的意義の検討2009

    • Author(s)
      村雲芳樹、萩原純孝、高橋雅英
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] GDNF-RETシグナル伝達系におけるDOK6の役割2009

    • Author(s)
      黒土愛
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Girdin は成体脳における新生ニューロンの移動をコントロールする2009

    • Author(s)
      王芸
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD109の高発現は扁平上皮の癌化に関係する2009

    • Author(s)
      萩原純孝
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] GDNF-RETシグナル伝達系におけるDOK6の機能解析2009

    • Author(s)
      黒土愛
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱癌におけるCD109発現の予後との関連性の検討2009

    • Author(s)
      萩倉美奈子
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] RFPによる細胞運動の制御とその子宮内膜癌における意義2009

    • Author(s)
      加藤琢哉
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト神経膠芽腫細胞におけるCD109発現の生物学的意義の検討2009

    • Author(s)
      村雲芳樹
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] v-SrcによるSPHK1 mRNA安定化と発現増強2008

    • Author(s)
      祖父江沙矢加、村上真史、坂野喜子、伊藤裕美、高四強、古畑彩子、高木明、小嶋哲人、野澤義則、村手隆、市原正智
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔癌におけるCD109の発現2008

    • Author(s)
      萩原純孝、村雲芳樹、重富俊雄、光藤健司、藤内祝、上田実、高橋雅英
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 基底細胞型乳癌の新しいマーカーとてのCD1092008

    • Author(s)
      長谷川正規、森谷鈴子、三井伸二、佐藤朋子、時々輪真由美、村雲芳樹、市原周、高橋雅英
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] v-SrcによるSPHK1 mRNA安定化と発現増強2008

    • Author(s)
      祖父江沙矢加
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] High-level expression of CD109 is frequently detected in lung squamous cell carcinomas.2008

    • Author(s)
      Murakumo, Y
    • Organizer
      99th Annual Meeting, American associationfor Cancer Research
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 基底細胞型乳癌の新しいマーカーとしてのCD109.2008

    • Author(s)
      長谷川正規
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 乳腺腺筋上皮腫(adenomyoepithelioma)の1例.2008

    • Author(s)
      時々輪真由美
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Choroid plexus papillary carcinomaの一例.2008

    • Author(s)
      鈴木智景
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 皮膚腫瘍におけるCD109の発現2008

    • Author(s)
      長谷川正規
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝性の癌 その研究と臨床の最前線 RETチロシンキナーゼのシグナル伝達と発がん2008

    • Author(s)
      高橋雅英
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] TBP-2の発現抑制に関わる転写複合体の解析2008

    • Author(s)
      加藤琢哉
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 口腔癌におけるCD109の発現(CD109 expression in oral cancer).2008

    • Author(s)
      萩原純孝
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトREV7及びMAD2タンパク質の結合モチーフ配列の部分的オーバーラッピング2008

    • Author(s)
      花房朋
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2008 Annual Research Report
  • [Book] これからはじめる人のためのバイオ実験基本ガイド2010

    • Author(s)
      村雲芳樹, 他3名
    • Total Pages
      224
    • Publisher
      講談社
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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