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Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..

Research Project

Project/Area Number 20590414
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHyogo College of Medicine

Principal Investigator

YAMADA Naoko  Hyogo College of Medicine, 医学部, 講師 (10319858)

Co-Investigator(Kenkyū-buntansha) TERADA Nobuyuki  兵庫医科大学, 医学部, 教授 (50150339)
NAKASHO Keiji  兵庫医科大学, 医学部, 教授 (00217712)
OHYAMA Hideki  兵庫医科大学, 医学部, 准教授 (90280685)
YAMANEGI Koji  兵庫医科大学, 医学部, 講師 (00434944)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords腫瘍 / インターロイキン18 / 転移 / 骨肉腫
Research Abstract

IL-18 shows an anti-tumor action through activation of T cells and natural killer cells. We found another action of IL-18, i.e., the inhibition of metastasis by inducing the factor(s) in serum which suppresses the tumor cell mobility. In this study, we aimed to identify the tumor-cell migration inhibitory factor(s). We have revealed that IL-18 induces the factor(s) in not only serum but also the cell lysate of the liver and lung and that the factor(s) is a protein of molecular weight of less than 30,000 daltons. We have also found several candidates for the factor(s).

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results)

  • [Journal Article] Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.2010

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Nishioka T, Fukunaga S, Futani H, Okamura H, Terada N
    • Journal Title

      Oncol Rep. 24(6)

      Pages: 1621-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblasts stimulated via HLA-II molecules produce prostaglandin E(2) and regulate cytokine production from helper T cells.2010

    • Author(s)
      Kato-Kogoe N, Ohyama H, Nishimura F, Meguro M, Yoshizawa S, Okada Y, Nakasho K, Yamanegi K, Yamada N, Hata M, Higashi T, Terada N, Matsushita S
    • Journal Title

      Lab Invest. 90(12)

      Pages: 1747-56

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblasts stimulated via HLA-II molecules produce prostaglandin E(2) and regulate cytokine production from helper T cells.2010

    • Author(s)
      Kato-Kogoe N, Ohyama H, Nakasho K, Yamanegi K, Yamada N, Terada N, et al.
    • Journal Title

      Lab Invest.

      Volume: 90 Pages: 1747-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosar coma cells to NK cell-mediated cytotoxicity.2010

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Terada N, et al.
    • Journal Title

      Oncol Rep.

      Volume: 24 Pages: 1621-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy with Interleukin-18 in Combination with Preoperative Chemotherapy with Ifosfamide Effectively Inhibits Postoperative Progression of Pulmonary Metastases in a Mouse Osteosarcoma Model.2009

    • Author(s)
      Yamada N, Hata M, Ohyama H, Yamanegi K, Kogoe N, Nakasho K, Futani H, Okamura H, Terada N
    • Journal Title

      Tumour Biol. 30(4)

      Pages: 176-184

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Involvement of IL-23 and the Th17 Pathway in Periodontitis.2009

    • Author(s)
      Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, Hata M, Yamane J, Terada N
    • Journal Title

      J Dent Res. 88(7)

      Pages: 633-8

    • NAID

      130004570957

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy with Interleukin-18 in Combination with Preoperative Chemotherapy with Ifosfamide Effectively Inhibits Postoperative Progression of Pulmonary Metastases in a Mouse Osteosarcoma Model.2009

    • Author(s)
      Naoko Yamada, et al.
    • Journal Title

      Tumour Biol. 30

      Pages: 176-184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Involvement of IL-23 and the Th17 Pathway in Periodontitis.2009

    • Author(s)
      Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, et al.
    • Journal Title

      J Dent Res. 88

      Pages: 633-8

    • NAID

      130004570957

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha- galactosylceramide and interleukin-18.2008

    • Author(s)
      Nishio S, Yamada N, Ohyama H, Yamanegi K, Nakasho K, Hata M, Nakamura Y, Fukunaga S, Futani H, Yoshiya S, Ueda H, Taniguchi M, Okamura H, Terada N
    • Journal Title

      Cancer Sci. 99(1)

      Pages: 113-120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death.2008

    • Author(s)
      Yamanegi K, Yamane J, Hata M, Ohyama H, Yamada N, Kato-Kogoe N, Futani H, Nakasho K, Okamura H, Terada N
    • Journal Title

      J Cancer Res Clin Oncol. 135(7)

      Pages: 879-889

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.2008

    • Author(s)
      Ohyama H, Kato-Kogoe N, Nishimura F, Takeuchi-Hatanaka K, Matsushita S, Yamanegi K, Yamada N, Hata M, Nakasho K, Terada N
    • Journal Title

      J Interferon Cytokine Res. 28(9)

      Pages: 563-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-18.2008

    • Author(s)
      Nishio S., Yamada N, et al.
    • Journal Title

      Cancer Science 99

      Pages: 113-120

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒストン脱アセチル化阻害剤とDNAメチル化阻害剤の併用による抗腫瘍免疫細胞に対する感受性増加2010

    • Author(s)
      山根木康嗣、小林健太、大山秀樹、小越菜保子、西岡稔浩、秦正樹、山田直子、中正恵二、寺田信行
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠・授乳期のカルシウム制限が離乳後の骨代謝に及ぼす影響2010

    • Author(s)
      遠藤倫代、山田直子、寺田信行、蓬田健太郎, 等
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成長期と成熟期における生殖幹細胞の品質保証システムの質的変化2010

    • Author(s)
      蓬田健太郎、藤本寿々、遠藤倫代、山本遥菜、山田直子, 等
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨肉腫に対するIL-18とイホマイドの併用療法の可能性(Immunotherapy with interleukin-18 in combination with preoperative chemotherapy with ifosfamide effectively inhibits postoperative progression of pulmonary metastases in a mouse osteosarcoma model)2009

    • Author(s)
      山田直子、大山秀樹、山根木康嗣、小越菜保子、秦正樹、中正恵二、岡村春樹、寺田信行
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Cooperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.2009

    • Author(s)
      Naoko Yamada, Shoji Nishio, Hideki Ohyama, Koji Yamanegi, Keiji Nakasho, Haruki Okamura, Nobuyuki Terada
    • Organizer
      The 11th Mutagenesis and Experimental Pathology Society of Australia
    • Place of Presentation
      Sydney, NSW, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] IL12RB2転写制御領域の多型はT細胞とNK細胞との間で異なった影響を及ぼす2009

    • Author(s)
      大山秀樹,小越菜保子,西岡稔浩,中正恵二,山根木康嗣,山田直子,秦正樹,山根順子,寺田信行
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] DNAメチル化阻害剤とヒストン脱アセチル化阻害剤の併用によるヒト骨肉腫細胞の抗腫 瘍免疫細胞抵抗性の減弱2009

    • Author(s)
      山根順子,山根木康嗣,大山秀樹,小越菜保子,秦正樹,山田直子,中正恵二,寺田信行
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒストン脱アセチル化阻害剤によるヒト骨肉腫細胞の免 疫療法抵抗性の減弱2009

    • Author(s)
      山根木康嗣,山根順子,大山秀樹,小越菜保子,秦正樹,山田直子,中正恵二,寺田信行
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhanced Suppression of Pulmonary Metastasis of Malignant Melanoma Cells by Combined Administration of -Galactosylceramide and Interleukin-18.2009

    • Author(s)
      Nishio S, Yamada N, Fukunaga S, Fukunishi S, Futani H, Okamura H, Terada N, Yoshiya S
    • Organizer
      The 55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas, Nevada
    • Related Report
      2010 Final Research Report
  • [Presentation] Coperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.2009

    • Author(s)
      Naoko Yamada, et al.
    • Organizer
      The 11th Mutagenesis and Experimental Pathology Society of Australia
    • Place of Presentation
      Sydney, NSW, Australia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enhanced Suppression of Pulmonary Metastasis of Malignant Melanoma Cells by Combined Administration of α-Galactosylceramide and Interleukin-18.2009

    • Author(s)
      Nishio S., Yamada N, et al.
    • Organizer
      The 55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas, Nevada.
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト骨肉腫細胞の免疫療法抵抗性に対するhistone deacetylase inhibitorの効果2008

    • Author(s)
      山根木康嗣、山根順子、秦正樹、大山秀樹、山田直子、小越菜保子、中正恵二、寺田信行
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] IL12RB2転写制御領域の遺伝子多型が侵襲性歯周炎に対する疾患感受性の個体差に及ぼす影響2008

    • Author(s)
      大山秀樹、畑中加珠、小越菜保子、西村英紀、曽我賢彦、中正恵二、山根木康嗣、山田直子、秦正樹、山根順子、高柴正悟、寺田信行
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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