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Novel function of histamine in atherosclerotic artery

Research Project

Project/Area Number 20590416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TANIMOTO Akihide  University of Occupational and Environmental Health, Japan, 医歯学総合研究科, 教授 (10217151)

Co-Investigator(Kenkyū-buntansha) SASAGURI Yasuyuki  産業医科大学, 医学部, 教授 (60140646)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords動脈硬化 / ヒスタミン / ヒスタミンレセプター(HR) / ヒスチジン脱炭酸酵素 / HDC / apoE-KOマウス / HR / スカベンジャー受容体 / 炎症因子 / ヒスチジン脱炭酸酵素(HDC) / HDC/apoE-KOマウス / HR/apoE-KOマウス / ヒスタミンレセプター
Research Abstract

The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.2011

    • Author(s)
      Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol. in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.2011

    • Author(s)
      Wang KY, Tanimoto A, et al.
    • Journal Title

      Arteriosclerosis, Thrombosis and Vascular Biology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. Model for Nonalcoholic Steatohepatitis in Mice.2010

    • Author(s)
      Wang KY, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano KI, Tsukada H, Sasaguri Y.
    • Journal Title

      Am J Pathol. 177

      Pages: 713-723

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of histamine in atherosclerotic lesion.2010

    • Author(s)
      Wang KY, Tanimoto A, Sasaguri Y.
    • Journal Title

      J UOEH. 32(Review)

      Pages: 63-71

    • NAID

      110007588849

    • Related Report
      2010 Final Research Report
  • [Journal Article] Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. Model for Nonalcoholic Steatohepatitis in Mice.2010

    • Author(s)
      Wang KY, Tanimoto A, et al.
    • Journal Title

      American Journal of Pathology

      Volume: 177 Pages: 713-723

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化病変におけるヒスタミンの役割2010

    • Author(s)
      王克よう, 谷本昭英, 笹栗靖之
    • Journal Title

      産業医科大学雑誌 32

      Pages: 63-71

    • NAID

      110007588849

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒスタミン受容体HH1RとHH2R-KOマウスにおけるコレステロールとコール酸の代謝の研究2010

    • Author(s)
      王克よう, 谷本昭英, 他
    • Organizer
      日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Emerging Links between Histamine Signaling and Glucose/Lipid metabolism2010

    • Author(s)
      王克よう, 谷本昭英, 他
    • Organizer
      日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粥状動脈硬化におけるヒスタミン受容体(HH1R、HH2R)の役割2010

    • Author(s)
      王克よう, 谷本昭英, 他
    • Organizer
      日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粥状動脈硬化におけるヒスタミン受容体(HH1R、HH2R)の役割2010

    • Author(s)
      王克よう, 谷本昭英, 笹栗靖之
    • Organizer
      日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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