| Project/Area Number |
20590416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TANIMOTO Akihide University of Occupational and Environmental Health, Japan, 医歯学総合研究科, 教授 (10217151)
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| Co-Investigator(Kenkyū-buntansha) |
SASAGURI Yasuyuki 産業医科大学, 医学部, 教授 (60140646)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動脈硬化 / ヒスタミン / ヒスタミンレセプター(HR) / ヒスチジン脱炭酸酵素 / HDC / apoE-KOマウス / HR / スカベンジャー受容体 / 炎症因子 / ヒスチジン脱炭酸酵素(HDC) / HDC/apoE-KOマウス / HR/apoE-KOマウス / ヒスタミンレセプター |
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| Research Abstract |
The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.
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