Mechanism of tumor promoting effect by mesenchymal progenitor cell

• Project/Area Number: 20590417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: ISHII Genichiro National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 臨床開発センター, 室長 (00270869)
• Co-Investigator(Kenkyū-buntansha): OCHIAI Atsushi 独立行政法人国立がん研究センター, 東病院臨床開発センター・臨床腫瘍病理部, 部長 (60183034)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 間葉系前駆細胞 / がん間質 / がん進展 / 線維芽細胞 / 間葉系幹細胞 / がん生着

Research Abstract

This study showed that vascular adventitial fibroblast (VAFs) and bone-marrow derived fibroblast contain mesenchymal progenitor cells. Moreover we clarified that VAFs enhanced tumor formation, although "immature status" of VAFs did not contribute to enhanced tumor formation.

Research Products

• [Journal Article] Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. (2011)
  • Author(s): Aokage K, Ishii G, Ohtaki Y, Yamaguchi Y, Hishida T, Yoshida J, Nishimura M, Nagai K, Ochiai A
  • Journal Title: Int J Cancer. 128(7) Pages: 1585-95
• [Journal Article] Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. (2011)
  • Author(s): Aokage, K, Ishii G, et al.
  • Journal Title: Int.J.Cancer Volume: 128(7) Pages: 1585-1595
  • Peer Reviewed
• [Journal Article] A novel histopathological evaluation method predicting the outcome of non-small cell lung cancer treated by neoadjuvant therapy : the prognostic importance of the area of residual tumor. (2010)
  • Author(s): Yamane Y, Ishii G, Goto K, Kojima M, Nakao M, Shimada Y, Nishiwaki Y, Nagai K, Kohrogi H, Ochiai A
  • Journal Title: J Thorac Oncol. 5(1) Pages: 49-55
• [Journal Article] Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung : Tumor Budding As an Index to Predict the Potential Aggressiveness. (2010)
  • Author(s): Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, Ochiai A
  • Journal Title: J Thorac Oncol. 5(9) Pages: 1361-8
• [Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells : a novel character of tumor educated fibroblasts. (2010)
  • Author(s): Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T, Ochiai A
  • Journal Title: Int J Oncol. 37(2) Pages: 317-25
• [Journal Article] Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma. (2010)
  • Author(s): Ohtaki Y, Ishii G, Nagai K, Ashimine S, Kuwata T, Hishida T, Nishimura M, Yoshida J, Takeyoshi I, Ochiai A
  • Journal Title: J Thorac Oncol. 5(10) Pages: 1507-15
• [Journal Article] A novel histopathological evaluation method predicting the outcome of non-small cell lung cancer treated by neoadjuvant therapy : The prognostic importance of the area of residual tumor. (2010)
  • Author(s): Yamane Y, Ishii G, et al.
  • Journal Title: J.Thorac Oncol. Volume: 5(1) Pages: 49-55
  • Peer Reviewed
• [Journal Article] Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer. (2010)
  • Author(s): Mitsunaga S, Ishii G, et al.
  • Journal Title: Int.J.Cancer Volume: 127(4) Pages: 805-819
  • Peer Reviewed
• [Journal Article] CD133 expression in rectal cancer after preoperative chemoradiotherapy. (2010)
  • Author(s): Kojima M, Ishii G, et al.
  • Journal Title: Cancer Sci. Volume: 101(4) Pages: 906-912
  • NAID: 10026590792
  • Peer Reviewed
• [Journal Article] Extratumoral vascular invasion is a significant prognostic indicator and apredicting factor of distant metastasis in non-small cell lung cancer. (2010)
  • Author(s): Shimada Y, Ishii G, et al.
  • Journal Title: J Thorac Oncol Volume: 5(7) Pages: 970-975
  • Peer Reviewed
• [Journal Article] Histopathological features of the tumor budding in adenocarcinoma of the lung : Tumor budding as an index to predict the potential aggressiveness. (2010)
  • Author(s): Yamaguchi Y, Ishii G, et al.
  • Journal Title: J Thorac Oncol. Volume: 5(9) Pages: 1361-1368
  • Peer Reviewed
• [Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells ; A novel character of tumor educated fibroblasts. (2010)
  • Author(s): Ishii G, et al.
  • Journal Title: Int.J.Oncol. Volume: 37(2) Pages: 317-325
  • Peer Reviewed
• [Journal Article] Stromal Macrophage Expressing CD204 Is Associated with Tumor Aggressiveness in Lung Adenocarcinoma. (2010)
  • Author(s): Ohtaki Y, Ishii G, et al.
  • Journal Title: J Thorac Oncol Volume: 5(10) Pages: 1507-1515
  • Peer Reviewed
• [Journal Article] Structural and biological properties of a papillary component generating a micropapillary component in lung adenocarcinoma (2010)
  • Author(s): Nagano T.
  • Journal Title: Lung Cancer 67(3) Pages: 282-9
  • Peer Reviewed
• [Journal Article] Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. (2009)
  • Author(s): Nakao M, Ishii G, Nagai K, Kawase A, Kenmotsu H, Kon-No H, Hishida T, Nishimura M, Yoshida J, Ochiai A
  • Journal Title: Cancer. 115(12) Pages: 2732-43
• [Journal Article] Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy (2009)
  • Author(s): Ohta, S.
  • Journal Title: Lung Cancer 64(1) Pages: 98-104
  • Peer Reviewed
• [Journal Article] Expression of Breast Cancer Resistance Protein is Associated with a Poor Clinical Outcome in Patients with Small-Cell Lung Cancer (2009)
  • Author(s): Kim Y.
  • Journal Title: Lung Cancer 65(1) Pages: 105-11
  • Peer Reviewed
• [Journal Article] Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma (2009)
  • Author(s): Nakao M.
  • Journal Title: Cancer 115(12) Pages: 2732-43
  • Peer Reviewed
• [Journal Article] Stromal MCP-1 in mammary tumors induces tumor associated macrophage infiltration and contributes to tumor progression (2009)
  • Author(s): Fujimoto H.
  • Journal Title: Int.J Cancer 125(6) Pages: 1276-84
  • Peer Reviewed
• [Journal Article] Prostate-specific antigen enhances bioavailability of insulin-like growth factor by degrading insulin-like growth factor binding protein 5 (2009)
  • Author(s): Maeda H.
  • Journal Title: Biochem Biophys Res Commun 381 Pages: 311-316
  • Peer Reviewed
• [Journal Article] Expression of podoplanin, CD44, and P63 in squamous cell carcinoma of the lung (2009)
  • Author(s): Shimada Y.
  • Journal Title: Cancer Sci 100(1) Pages: 2054-9
  • Peer Reviewed
• [Journal Article] CD44 expression during tumor progression of follicular lymphoma (2009)
  • Author(s): Higashi M.
  • Journal Title: Oncol.Report 25(2) Pages: 1135-40
  • Peer Reviewed
• [Journal Article] Improvement of the breaking strength of wound by combined treatment with recombinant human G-CSF, recombinant human M-CSF, and a TGF-beta1 receptor kinase inhibitor in rat skin. (2008)
  • Author(s): Sugiyama K, Ishii G, Ochiai A, Esumi H
  • Journal Title: Cancer Sci. 99(5) Pages: 1021-8
• [Journal Article] Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells. (2008)
  • Author(s): Hoshino A, Chiba H, Nagai K, Ishii G, Ochiai A
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 305-310
• [Journal Article] Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. (2008)
  • Author(s): Kawase A, Ishii G, Nagai K, Ito T, Nagano T, Murata Y, Hishida T, Nishimura M, Yoshida J, Suzuki K, Ochiai A
  • Journal Title: Int J Cancer. 123(5) Pages: 1053-9
• [Journal Article] CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. (2008)
  • Author(s): Chiba H, Ishii G, Ito TK, Aoyagi K, Sasaki H, Nagai K, Ochiai A
  • Journal Title: Stem Cells. 26(10) Pages: 2523-30