Mechanism of tumor promoting effect by mesenchymal progenitor cell
Project/Area Number |
20590417
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
Principal Investigator |
ISHII Genichiro National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 臨床開発センター, 室長 (00270869)
|
Co-Investigator(Kenkyū-buntansha) |
OCHIAI Atsushi 独立行政法人国立がん研究センター, 東病院臨床開発センター・臨床腫瘍病理部, 部長 (60183034)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 間葉系前駆細胞 / がん間質 / がん進展 / 線維芽細胞 / 間葉系幹細胞 / がん生着 |
Research Abstract |
This study showed that vascular adventitial fibroblast (VAFs) and bone-marrow derived fibroblast contain mesenchymal progenitor cells. Moreover we clarified that VAFs enhanced tumor formation, although "immature status" of VAFs did not contribute to enhanced tumor formation.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung : Tumor Budding As an Index to Predict the Potential Aggressiveness.2010
Author(s)
Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, Ochiai A
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Journal Title
J Thorac Oncol. 5(9)
Pages: 1361-8
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[Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells : a novel character of tumor educated fibroblasts.2010
Author(s)
Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T, Ochiai A
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Journal Title
Int J Oncol. 37(2)
Pages: 317-25
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[Journal Article] Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma.2008
Author(s)
Kawase A, Ishii G, Nagai K, Ito T, Nagano T, Murata Y, Hishida T, Nishimura M, Yoshida J, Suzuki K, Ochiai A
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Journal Title
Int J Cancer. 123(5)
Pages: 1053-9
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