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Molecular study of anti-protective immune response upon malaria

Research Project

Project/Area Number 20590421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionGunma University

Principal Investigator

SUZUE Kazutomo  Gunma University, 大学院・医学系研究科, 講師 (00333485)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsマラリア / 防御免疫 / 免疫記憶 / ワクチン / マウス
Research Abstract

We have observed the functional changes of parasite-nonspecific T cells upon infection with Plasmodium. In this study, we addressed about the mechanisms and its impact of functional changes of parasite-non-specific T cells. First we identified that the functional changes of T cells are distinguishable of the activation pathway of conventional T cells. Next we identified that functional changes of T cells are influenced with another immune responses such as protection against Listeria and DNFB-induced contact hypersensitivity reaction.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (6 results)

  • [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice.2011

    • Author(s)
      Matsuzaki-Moriya C, Tu L, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimokawa C, Hisaeda H.
    • Journal Title

      Eur J Immunol. 41

      Pages: 1365-75

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice.2011

    • Author(s)
      Matsuzaki-Moriya C, Tu L, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimokawa C, Hisaeda H.
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 1365-1375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of SIRPα for protective immunity against Leishmania major.2010

    • Author(s)
      Morimoto N, Murata Y, Motegi SI, Suzue K, Saito Y, Okazawa H, Ohnishi H, Kotani T, Kusakari S, Ishikawa O, Matozaki T.
    • Journal Title

      Biochem Biophys Res Commun. 22

      Pages: 385-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010

    • Author(s)
      Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H.
    • Journal Title

      Biochem Biophys Res Commun. 26

      Pages: 790-5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010

    • Author(s)
      Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 402 Pages: 790-795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of SIRPα for protective immunity against Leishmania major.2010

    • Author(s)
      Morimoto N, Murata Y, Motegi S, Suzue K, Saito Y, Okazawa H, Ohnishi H, Kotani T, Kusakari S, Ishikawa O, Matozaki T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 401 Pages: 385-389

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection.2008

    • Author(s)
      Suzue K, Kobayashi S, Takeuchi T, Suzuki M, Koyasu S.
    • Journal Title

      Int.Immunol. 20

      Pages: 337-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Parasite non-specific T cells were suppressed upon malaria infection2010

    • Author(s)
      Suzue K, Udagawa M, Kitamura Y, Hisaeda H, Koyasu S, Suzuki M
    • Organizer
      14^<th> International congress of immunology
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-08-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Parasite non-specific T cells were suppressed upon malaria in fection2010

    • Author(s)
      Kazutomo Suzue, Mai Udagawa, Yuta Kitamura, Hajime Hisaeda, Shigeo Koyasu, Mamoru Suzuki
    • Organizer
      14^<th> International congress of immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] マラリア感染で起こる原虫非特異的T細胞の機能修飾によってもたらされる影響2010

    • Author(s)
      鈴江一友、宇田川麻衣、北村裕太、久枝一、小安重夫、鈴木守
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] マラリア感染で起こる原虫非特異的T細胞の機能修飾によってもたらされる影響2010

    • Author(s)
      鈴江一友、宇田川麻衣、北村裕太、久枝一、小安重夫、鈴木守
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Book] 動物モデル活用ハンドブック(感染症モデル)(秋山徹、河府和義編)2011

    • Author(s)
      鈴江一友
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] 人獣共通感染症(マラリア、喜田宏編)2011

    • Author(s)
      鈴江一友、鈴木守
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] マウス・ラット疾患モデル活用ハンドブック2011

    • Author(s)
      秋山徹編
    • Total Pages
      604
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 人獣共通感染症2011

    • Author(s)
      喜田宏編
    • Total Pages
      551
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Annual Research Report
  • [Book] カラーイラストで学ぶ集中講義 生理学(増殖因子をはじめとする各種サイトカインはどう作用するのか?、岡田隆夫編)2008

    • Author(s)
      鈴江一友、鯉渕典之
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学増刊 Vol.26 No.20 樹状細胞による免疫制御と臨床応用(リーシュマニア原虫と樹状細胞、稲葉 カヨ 編)2008

    • Author(s)
      鈴江一友、小安重夫
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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