Reaction mechanisms and physiological roles of sulfur-containing amino acids degradation enzyme in pathogenic protozoa.
| Project/Area Number |
20590429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Keio University |
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Principal Investigator |
SATO Dan Keio University, 政策・メディア研究科, 助教 (50468477)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 寄生性原虫 / 創薬開発 / 含硫アミノ酸 / 結晶構造解析 / メタボロミクス / 原虫 / アミノ酸代謝 |
|---|
| Research Abstract |
Amoebiasis is one of the major infectious diseases worldwide. We focus on the sulfur-containing amino acids degradation enzymes, which present exclusively in the pathogen but missing in humans. We investigated the reaction mechanism, the characterization as a drug target, and physiological roles of the enzymes. We successfully elucidated the reaction mechanism at crystal structure level, and demonstrated that how the lead compounds exhibited the toxicity to amoeba. Our research will provide the valuable information on the rational design of novel anti-amoebic drugs.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Cytotoxic effect of amide derivatives of S-trifluoromethylhomocysteine to the enteric protozoan parasite Entamoeba histolytica.2010
Author(s)
Dan Sato, Seiki Kobayashi, Hiroyuki Yasui, Norio Shibata, Takeshi Toru, Masaichi Yamamoto, Gensuke Tokoro, Vahab Ali, Tomoyoshi Soga, Tsutomu Takeuchi, Makoto Suematsu, Tomoyoshi Nozaki
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Journal Title
International Journal of Antimicrobial Agent. 35(1)
Pages: 56-61
Related Report
Peer Reviewed
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