| Project/Area Number |
20590431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Tokai University |
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Principal Investigator |
TACHIBANA Hiroshi Tokai University, 医学部, 准教授 (10147168)
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| Co-Investigator(Renkei-kenkyūsha) |
OBAYASHI Seiki 慶応義塾大学, 医学部, 講師 (70112688)
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| Research Collaborator |
ANABE Kazuyuki 大阪大学, 微生物病研究所, 教授 (40047410)
YANAGI Tetsuo 長崎大学, 熱帯医学研究所, 助手 (10174541)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 赤痢アメーバ / Entamoeba dispar / Entamoeba nuttalli / 表面蛋白質 / 遺伝子多型 / Intermediate subunit lectin |
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| Research Abstract |
Intermediate subunit of Gal/GalNAc lectin (Igl) located on the surface of Entamoeba histolytica trophozoites is involved in amebic adherence to host cells. When genetic diversity of two Igl genes was analyzed in 22 isolates of E. histolytica, Igl1 and Igl2 genes were divided into 5 and 2 types, respectively. Since seven types of combination between Igl1 and Igl2 were observed, occurrence of recombination between the two loci was suggested. Polymorphism of two Igl genes was also observed in E. dispar and E. nuttalli isolates.
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