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Polymorphic analysis of surface lectins (IGL) of Entamoeba histolytica and related Entamoeba spp.

Research Project

Project/Area Number 20590431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionTokai University

Principal Investigator

TACHIBANA Hiroshi  Tokai University, 医学部, 准教授 (10147168)

Co-Investigator(Renkei-kenkyūsha) OBAYASHI Seiki  慶応義塾大学, 医学部, 講師 (70112688)
Research Collaborator ANABE Kazuyuki  大阪大学, 微生物病研究所, 教授 (40047410)
YANAGI Tetsuo  長崎大学, 熱帯医学研究所, 助手 (10174541)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords赤痢アメーバ / Entamoeba dispar / Entamoeba nuttalli / 表面蛋白質 / 遺伝子多型 / Intermediate subunit lectin
Research Abstract

Intermediate subunit of Gal/GalNAc lectin (Igl) located on the surface of Entamoeba histolytica trophozoites is involved in amebic adherence to host cells. When genetic diversity of two Igl genes was analyzed in 22 isolates of E. histolytica, Igl1 and Igl2 genes were divided into 5 and 2 types, respectively. Since seven types of combination between Igl1 and Igl2 were observed, occurrence of recombination between the two loci was suggested. Polymorphism of two Igl genes was also observed in E. dispar and E. nuttalli isolates.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (12 results)

  • [Journal Article] High prevalence of Entamoeba infections in captive long-tailed macaques in China.2011

    • Author(s)
      Feng M., Yang B., Yang L., Fu Y., Zhuang Y., Liang L., Xu Q., Cheng X., Tachibana H.
    • Journal Title

      Parasitol.Res. 108(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of Entamoeba infections in captive long-tailed macaques in China2011

    • Author(s)
      Feng M., et al.
    • Journal Title

      Parasitology Research

      Volume: 108(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of serine-rich protein genes of Entamoeba histolytica isolates obtained from institutions for the mentally retarded in Kanagawa and Shizuoka Prefectures, Japan.2010

    • Author(s)
      Fu Y.-F., Nagakura K., Cheng X.-J., Tachibana H.
    • Journal Title

      Parasitol.Res. 107

      Pages: 999-1002

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of serine-rich protein genes of Entamoeba histolytica isolates obtained from institutions for the mentally retarded in Kanagawa and Shizuoka Prefectures, Japan2010

    • Author(s)
      Fu Y.-F., et al.
    • Journal Title

      Parasitology Research

      Volume: 107 Pages: 999-1002

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques.2009

    • Author(s)
      Tachibana H., Yanagi T., Akatsuka A., Kobayashi S., Kanbara H., Tsutsumi V.
    • Journal Title

      Parasitology 136

      Pages: 1169-1177

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA characterization of simian Entamoeba histolytica-like strains to differentiate them from Entamoeba histolytica.2009

    • Author(s)
      Takano J., Tachibana H., Kato M., Narita T., Yanagi T., Yasutomi Y., Fujimoto K.
    • Journal Title

      Parasitol.Res. 105

      Pages: 929-937

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Entamoeba histolytica intermediate subunit lectin-specific human monoclonal antibodies generated in transgenic mice expressing human immunoglobulin loci.2009

    • Author(s)
      Tachibana H., Cheng X.-J., Tsukamoto H., Itoh J.
    • Journal Title

      Infect.Immun. 77

      Pages: 549-556

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques2009

    • Author(s)
      Tachibana H., et al.
    • Journal Title

      Parasitology 136

      Pages: 1169-1177

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA characterization of simian Entamoeba histolytica-like strains to differentiate them from Entamoeba histolytica2009

    • Author(s)
      Takano J., et al.
    • Journal Title

      Parasitol. Res. 105

      Pages: 929-937

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Entamoeba histolytica intermediate subunit lectin-specific human monoclonal antibodies generated in transgenic mice expressing human immunoglobulin loci2009

    • Author(s)
      Tachibana H., et al.
    • Journal Title

      Infect. Immun. 77

      Pages: 549-556

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] インドのアカゲザルからのEntamoeba nuttalliの分離と性状解析2010

    • Author(s)
      橘裕司,柳哲雄,小林正規,平山謙二,Ganguly S.
    • Organizer
      第51回日本熱帯医学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] インドのアカゲザルからのEntamoeba nuttalliの分離と性状解析2010

    • Author(s)
      橘裕司, 他
    • Organizer
      第51回日本熱帯医学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 病原アメーバ種Entamoeba nuttalliのニホンザルからの分離と性状解析2010

    • Author(s)
      橘裕司,小林正規,柳哲雄,松林清明
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 病原アメーバ種Entamoeba nuttalliのニホンザルからの分離とその性状解析2010

    • Author(s)
      橘裕司, 他
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ネパールのアカゲザルにおけるEntamoeba nuttalliの感染状況2009

    • Author(s)
      橘裕司,柳哲雄,Lama C.,小林正規,Sherchand J., 平山謙二
    • Organizer
      第50回日本熱帯医学会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] ネパールのアカゲザルにおけるEntamoeba nuttalliの感染状況2009

    • Author(s)
      橘裕司, 他
    • Organizer
      第50回日本熱帯医学会大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 赤痢アメーバの表面レクチンIGLに特異的なヒトモノクローナル抗体の性状解析2009

    • Author(s)
      橘裕司,程訓佳,塚本秀雄,伊東丈夫
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 赤痢アメーバの表面レクチンIGLに特異的なヒトモノクローナル抗体の性状解析2009

    • Author(s)
      橘 裕司, 他
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      法政大学市ヶ谷キャンパス外濠校舎
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Production and characterization of fully human monoclonal antibodies to Entamoeba histolytica intermediate subunit lectin2009

    • Author(s)
      Tachibana H., Cheng X.-J., Tsukamoto H., Itoh J.
    • Organizer
      43rd Annual U.S-Japan Joint Conference on Parasitic Diseases.
    • Place of Presentation
      東京
    • Year and Date
      2009-01-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 長崎市の飼育ニホンザルから分離されたEntamoeba nuttalliの性状解析2008

    • Author(s)
      橘裕司,柳哲雄,小林正規,神原廣二
    • Organizer
      第49回日本熱帯医学会大会・第23回日本国際保健医療学会学術大会合同大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Seroprevalence of Entamoeba histolytica infection in China2008

    • Author(s)
      Cheng X., Chen Y. Yang B., Feng M., Xu L., Tachibana H.
    • Organizer
      13th International Congress on Infectious Diseases.
    • Place of Presentation
      クアラルンプール
    • Year and Date
      2008-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 赤痢アメーバにおける2つのIgl遺伝子の多型解析2008

    • Author(s)
      橘裕司,小林正規,柳哲雄,竹内勤,田邉和裄
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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