| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Based on my previous evidences that linkage of sialic acid to mucins associates with expulsion of an gastrointestinal nematode, Nippostrongylus brasiliensis, from mice, and that existence of a small amount of sialomucin at the establishment of the worms, I tried to characterize ligand molecules expressed on the worms which affect the establishment/expulsion, especially those of sialomucin. No directional characteristic of the worms towards sialomucin was detected. Characterization of ligands of sialomucin is still going on. Analyses of glycosylation of mucins by the lectin-array and the MALDI-TOF-MS supported previously reported results.
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