Molecular Analysis of Life and Death in Pathogenic Fungi Cryptococcus neoformans : Cell Cycle Cntrol and Interaction between Fungi and Bacteria
Project/Area Number |
20590437
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Chiba University |
Principal Investigator |
KAWAMOTO Susumu Chiba University, 真菌医学研究センター, 教授 (80125921)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 真菌 / 感染症 / 細胞周期 / 遺伝子 / タンパク質 / 国際情報交換 / チェコ:ハンガリー / 蛋白質 |
Research Abstract |
The G1 Cyclin CnCln1 gene, a key molecule in the cell cycle control in a pathogenic yeast, Cryptococcus neoformans, was cloned, identified and characterized. Interaction between cell cycle control and stress (hypoxia) response was analyzed. Also, localization of triosephosphate isomerase, the molecules responsible for contact-mediated killing of Cryptococcus, on the surface of Staphylococcus was demonstrated by scanning immunoelectron microscopy.
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Report
(4 results)
Research Products
(62 results)
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[Presentation] Understanding cell control in the pathogenic yeast Cryptococcus neoformans.2009
Author(s)
Virtudazo, E.V., Ohkusu, M., Ohata, M., Miklos, I., Sipiczki, Matthias, Aoki, S., Takeo, K., Kawamoto S.
Organizer
ISHAM 2009.
Place of Presentation
Tokyo, Japan.
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[Presentation] Towards molecular understanding of cell cycle regulation and cell signaling in Cryptococcus neoformans.2008
Author(s)
Kawamoto S, Virtudazo E, Ohata M, Ohkusu M, Shimizu K, Yamaguchi M, Miklos I, Sipiczki M, Moranova Z, Raclavsky V, Takeo K
Organizer
7th International Conference on Cryptococcus and Cryptococcosis.
Place of Presentation
Nagasaki
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