| Project/Area Number |
20590439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TSUJIMURA Kunio Hamamatsu University School of Medicine, 医学部, 准教授 (10227407)
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| Co-Investigator(Kenkyū-buntansha) |
KOIDE Yukio 浜松医科大学, 医学部, 理事 (30126809)
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
UCHIJIMA Masato 浜松医科大学, 医学部, 助教 (20252174)
SETO Shintaro 浜松医科大学, 医学部, 助教 (50383203)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ワクチン / 結核菌 / 糖鎖 / リポソーム / 結核 / オリゴマンノース / Th1 |
|---|
| Research Abstract |
A novel vaccine against Mycobacterium tuberculosis was established employing a tuberculosis-protective antigen MPT51 and oligomannose-coated liposomes. Antigen-specific T-cell responses and antibody production were effectively induced in mice vaccinated with this composition. In addition, induced cytokine profiles and antibody classes suggested that this newly formulated vaccine could elicit Th1-type immune responses known to be important for the protection against tuberculosis.
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